NZ211526A - Cyclosporin derivatives with d-acyloxy-alpha-amino acid residue at the 8-position and pharmaceutical compositions - Google Patents

Cyclosporin derivatives with d-acyloxy-alpha-amino acid residue at the 8-position and pharmaceutical compositions

Info

Publication number
NZ211526A
NZ211526A NZ211526A NZ21152685A NZ211526A NZ 211526 A NZ211526 A NZ 211526A NZ 211526 A NZ211526 A NZ 211526A NZ 21152685 A NZ21152685 A NZ 21152685A NZ 211526 A NZ211526 A NZ 211526A
Authority
NZ
New Zealand
Prior art keywords
acyloxy
alpha
amino acid
pharmaceutical compositions
acid residue
Prior art date
Application number
NZ211526A
Other languages
English (en)
Inventor
R Wenger
R P Traber
H Kobel
H Hofmann
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848407618A external-priority patent/GB8407618D0/en
Priority claimed from GB848411922A external-priority patent/GB8411922D0/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of NZ211526A publication Critical patent/NZ211526A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ211526A 1984-03-23 1985-03-21 Cyclosporin derivatives with d-acyloxy-alpha-amino acid residue at the 8-position and pharmaceutical compositions NZ211526A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848407618A GB8407618D0 (en) 1984-03-23 1984-03-23 Organic compounds
GB848411922A GB8411922D0 (en) 1984-05-10 1984-05-10 Organic compounds

Publications (1)

Publication Number Publication Date
NZ211526A true NZ211526A (en) 1988-08-30

Family

ID=26287502

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ211526A NZ211526A (en) 1984-03-23 1985-03-21 Cyclosporin derivatives with d-acyloxy-alpha-amino acid residue at the 8-position and pharmaceutical compositions

Country Status (24)

Country Link
US (1) US4639434A (OSRAM)
JP (1) JPH08838B2 (OSRAM)
AT (1) AT388737B (OSRAM)
BE (1) BE901980A (OSRAM)
CA (1) CA1247546A (OSRAM)
CH (1) CH667274A5 (OSRAM)
CS (1) CS249542B2 (OSRAM)
DE (1) DE3509809A1 (OSRAM)
DK (1) DK128285A (OSRAM)
ES (1) ES8702926A1 (OSRAM)
FI (1) FI851120L (OSRAM)
FR (1) FR2561651B1 (OSRAM)
GB (1) GB2155936B (OSRAM)
GR (1) GR850716B (OSRAM)
HU (1) HU200786B (OSRAM)
IL (1) IL74681A (OSRAM)
IT (1) IT1199962B (OSRAM)
LU (1) LU85819A1 (OSRAM)
NL (1) NL8500828A (OSRAM)
NO (1) NO851160L (OSRAM)
NZ (1) NZ211526A (OSRAM)
PH (2) PH23357A (OSRAM)
PT (1) PT80149B (OSRAM)
SE (1) SE461334B (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH074269B2 (ja) 1984-10-04 1995-01-25 サンド・アクチエンゲゼルシャフト シクロスポリン類に対するモノクロ−ナル抗体
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
DE3884470T2 (de) * 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
DE3851152T2 (de) * 1987-09-03 1995-01-26 Univ Georgia Cyclosporin-augenmittel.
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5089390A (en) * 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
CH679119A5 (OSRAM) * 1988-05-13 1991-12-31 Sandoz Ag
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
ATE148469T1 (de) * 1990-11-02 1997-02-15 Sandoz Ag Zyklosporine
EP0487289B1 (en) 1990-11-20 1996-09-04 BEHRINGWERKE Aktiengesellschaft Cyclosporin immunoassay
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
RU2170741C2 (ru) * 1996-08-16 2001-07-20 Новартис Аг Способ получения циклоспорина
JP4261049B2 (ja) 1997-10-08 2009-04-30 アイソテクニカ インコーポレイテッド 重水素化シクロスポリンアナログおよび免疫調節剤としてのそれらの使用
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en) 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
CN100334106C (zh) * 2001-10-19 2007-08-29 伊索泰克尼卡股份有限公司 环孢菌素类似物的合成
DE60233150D1 (de) * 2001-10-19 2009-09-10 Isotechnika Inc Neue cyclosporin-analoge mikroemulsionsvorkonzentrate
CA2518265A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
JP2008514701A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
CN107496902B (zh) 2010-12-15 2022-01-18 康卓维尔制药公司 在氨基酸1和3位修改的环孢菌素类似分子
PL2683406T3 (pl) 2011-03-11 2019-11-29 Beth Israel Deaconess Medical Ct Inc Przeciwciała anty-cd40 i ich zastosowania
CN104877013B (zh) * 2015-06-03 2018-04-20 兰州大学 环孢菌素t及其制备方法和应用
BR112018004296B1 (pt) 2015-09-04 2020-05-05 Primatope Therapeutics Inc anticorpos anti-cd40 humanizados e usos dos mesmos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140753A (en) * 1981-01-09 1982-08-31 Sandoz Ag Novel cyclosporine
US4384996A (en) * 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins

Also Published As

Publication number Publication date
SE8501392D0 (sv) 1985-03-21
PT80149B (en) 1987-03-23
PH23357A (en) 1989-07-14
DK128285D0 (da) 1985-03-21
IT1199962B (it) 1989-01-05
CS249542B2 (en) 1987-03-12
IT8547852A1 (it) 1986-09-22
ES8702926A1 (es) 1987-01-16
JPH08838B2 (ja) 1996-01-10
SE8501392L (sv) 1985-09-24
ATA86385A (de) 1989-01-15
CA1247546A (en) 1988-12-28
BE901980A (fr) 1985-09-23
FR2561651B1 (fr) 1990-03-09
GR850716B (OSRAM) 1985-07-19
GB2155936A (en) 1985-10-02
FI851120A7 (fi) 1985-09-24
PT80149A (en) 1985-04-01
GB2155936B (en) 1987-09-16
ES541465A0 (es) 1987-01-16
NO851160L (no) 1985-09-24
GB8507270D0 (en) 1985-04-24
JPS60215700A (ja) 1985-10-29
LU85819A1 (fr) 1985-12-12
FI851120L (fi) 1985-09-24
NL8500828A (nl) 1985-10-16
AT388737B (de) 1989-08-25
IL74681A0 (en) 1985-06-30
DE3509809A1 (de) 1986-01-09
SE461334B (sv) 1990-02-05
IT8547852A0 (it) 1985-03-22
FI851120A0 (fi) 1985-03-20
PH21868A (en) 1988-03-25
US4639434A (en) 1987-01-27
IL74681A (en) 1989-09-10
HUT38370A (en) 1986-05-28
CH667274A5 (de) 1988-09-30
HU200786B (en) 1990-08-28
FR2561651A1 (fr) 1985-09-27
DK128285A (da) 1985-09-24

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