BE901704A - Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables. - Google Patents

Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables.

Info

Publication number
BE901704A
BE901704A BE0/214493A BE214493A BE901704A BE 901704 A BE901704 A BE 901704A BE 0/214493 A BE0/214493 A BE 0/214493A BE 214493 A BE214493 A BE 214493A BE 901704 A BE901704 A BE 901704A
Authority
BE
Belgium
Prior art keywords
semi
gelled masses
encapsulation process
permeable membranes
aqueous solution
Prior art date
Application number
BE0/214493A
Other languages
English (en)
French (fr)
Inventor
W G Tsang
A W S Shyr
Original Assignee
Damon Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Biotech Inc filed Critical Damon Biotech Inc
Publication of BE901704A publication Critical patent/BE901704A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/06Making microcapsules or microballoons by phase separation
    • B01J13/08Simple coacervation, i.e. addition of highly hydrophilic material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/20After-treatment of capsule walls, e.g. hardening
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012Cell encapsulation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
    • C12N5/163Animal cells one of the fusion partners being a B or a T lymphocyte
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides
    • C12N2533/74Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
BE0/214493A 1984-02-13 1985-02-11 Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables. BE901704A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/579,494 US4663286A (en) 1984-02-13 1984-02-13 Encapsulation of materials

Publications (1)

Publication Number Publication Date
BE901704A true BE901704A (fr) 1985-05-29

Family

ID=24317126

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214493A BE901704A (fr) 1984-02-13 1985-02-11 Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables.

Country Status (14)

Country Link
US (1) US4663286A (OSRAM)
JP (1) JPS60190229A (OSRAM)
AU (1) AU572609B2 (OSRAM)
BE (1) BE901704A (OSRAM)
CA (1) CA1238273A (OSRAM)
CH (1) CH665137A5 (OSRAM)
DE (1) DE3504724C2 (OSRAM)
DK (1) DK65285A (OSRAM)
FR (1) FR2559502B1 (OSRAM)
GB (1) GB2153780B (OSRAM)
IT (1) IT1184885B (OSRAM)
NL (1) NL8500352A (OSRAM)
NO (1) NO850535L (OSRAM)
SE (1) SE8500623L (OSRAM)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127989A3 (en) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Microencapsulation of living tissue and cells
SE8405105L (sv) * 1984-05-24 1985-11-25 Damon Biotech Inc Sett for screening av celler
US4680174A (en) * 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
US4871671A (en) * 1985-04-29 1989-10-03 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
IL79052A0 (en) * 1986-06-06 1986-11-30 Univ Ramot Device and process for production of alginate-shell beads containing biologically active material
JPS6434436A (en) * 1987-07-28 1989-02-03 Sanyo Chemical Ind Ltd Gel cellular beads and manufacture thereof
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US5389532A (en) * 1988-07-07 1995-02-14 Champagne Moet & Chandon Process of producing a dehydrated polysaccharide gel containing microorganisms for preparing fermented drinks
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel
AU635921B2 (en) * 1989-02-21 1993-04-08 Biosys Method and medium for packaging entomogenous nematodes
DE3908997A1 (de) * 1989-03-18 1990-09-20 Huels Chemische Werke Ag Verfahren zur herstellung immobilisierter hefen fuer die sektgaerung
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
WO1991007951A1 (en) * 1989-12-05 1991-06-13 Trancel Corporation Homologous guluronic acid alginate coating composition for in-vivo application and implantation and method of using same
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
WO1991009119A1 (en) * 1989-12-13 1991-06-27 Trancel Corporation Improved alginate microcapsules, methods of making and using same
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
ES2081384T3 (es) * 1990-04-25 1996-03-01 Hoechst Ag Preparado farmaceutico que contiene complejos de polielectrolitos en forma de microparticulas y por lo menos una sustancia activa.
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
FR2673122B1 (fr) * 1991-02-25 1994-09-09 Moet & Chandon Gel ionotrope deficient en entite ionique de gelification, procede de preparation d'un tel gel et utilisation de celui-ci notamment dans un procede d'elaboration de vin effervescent.
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
DK0585368T3 (da) * 1991-04-25 1998-03-16 Univ Brown Res Found Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter
AU687728B2 (en) * 1991-11-25 1998-03-05 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
WO1994015589A1 (en) * 1992-12-30 1994-07-21 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5545423A (en) * 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5170744A (en) * 1991-12-13 1992-12-15 Biosys Corporation Long-term storage of infective juvenile nematodes in pseudoplastic layers
AU673160B2 (en) 1992-02-28 1996-10-31 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5521079A (en) * 1994-01-24 1996-05-28 The Regents Of The University Of California Microcapsule generating system containing an air knife and method of encapsulating
ATE207727T1 (de) * 1992-05-29 2001-11-15 Univ California Beschichtetes transplantat sowie herstellungsverfahren dafür
US5429821A (en) * 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US5578314A (en) * 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
US6001387A (en) * 1992-05-29 1999-12-14 The Reguents Of The University Of California Spin disk encapsulation apparatus and method of use
ATE204470T1 (de) * 1992-05-29 2001-09-15 Vivorx Inc Mikroverkapselung von zellen
AU5728994A (en) * 1992-11-24 1994-06-22 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsules
DE4312970A1 (de) * 1993-04-21 1994-10-27 Juergen Dr Schrezenmeir Mikrokapsel sowie Verfahren und Vorrichtung zu ihrer Herstellung
ATE183078T1 (de) 1993-08-10 1999-08-15 Gore & Ass Zelleinkapselungsvorrichtung
US5965149A (en) * 1993-08-13 1999-10-12 Thermo Trilogy Corporation Granular formulation of biological entities with improved storage stability
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
AU681240C (en) * 1994-01-13 2006-12-07 Rogosin Institute, The Macroencapsulated secretory cells
US5876742A (en) * 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5514377A (en) * 1994-03-08 1996-05-07 The Regents Of The University Of California In situ dissolution of alginate coatings of biological tissue transplants
US5651980A (en) * 1994-04-15 1997-07-29 Biohybrid Technologies, Inc. Methods of use of uncoated gel particles
JPH11501512A (ja) * 1995-03-03 1999-02-09 メタボレックス,インコーポレイティド ゲル化ポリマーによる新規の被包方法
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
JP3265918B2 (ja) * 1995-06-15 2002-03-18 矢崎総業株式会社 乾燥したゲル被覆種子の復元方法
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
WO1997010807A1 (en) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US7041634B2 (en) 1995-09-27 2006-05-09 Emory University Method of inhibiting immune system destruction of transplanted viable cells
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
EP0914043B1 (en) * 1996-04-03 2003-10-01 The Rogosin Institute Implantable agarose-collagen beads containing cells which produce a diffusible biological product, and uses thereof
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6033887A (en) * 1997-05-05 2000-03-07 Champagne Moet & Chandon Dehydrated polysaccharide gel containing microorganisms, a sugar and a polyol for producing fermented drinks
GB2327074B (en) * 1997-07-07 2001-09-12 Norsk Hydro As Improvements in or relating to capsules
US6368612B1 (en) 1997-12-12 2002-04-09 Biohybrid Technologies Llc Devices for cloaking transplanted cells
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
EP1064087B1 (de) * 1998-03-19 2006-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Herstellung von nano- und mikrokapseln durch schichtweise polyelektrolyt-selbstassemblierung
US7101575B2 (en) * 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US6479146B1 (en) * 1998-03-19 2002-11-12 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften, E.V. Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates
EP1098696B2 (de) * 1998-07-15 2010-07-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Polyelektrolythüllen auf biologischen templaten
AU1623300A (en) * 1998-11-13 2000-06-05 Sensor Technologies, Inc. Monodisperse preparations useful with implanted devices
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
EP1194128A2 (en) 1999-06-23 2002-04-10 Sedum Laboratories Ionically formulated biomolecule microcarriers
AU2001246440A1 (en) * 2000-02-29 2001-09-12 Rainer Pommersheim Microcapsule, in particular, for immobilizing organic or inorganic solids, liquids and/or gases
US6649384B2 (en) 2000-07-05 2003-11-18 Islet Technology, Inc. System and method for encapsulating biological material by applying electrostatic charge to capsules
US20040191246A1 (en) * 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
US6790455B2 (en) * 2001-09-14 2004-09-14 The Research Foundation At State University Of New York Cell delivery system comprising a fibrous matrix and cells
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US20050095174A1 (en) * 2003-10-31 2005-05-05 Wolf David E. Semipermeable sensors for detecting analyte
DE102004013637A1 (de) * 2004-03-19 2005-10-13 Capsulution Nanoscience Ag Verfahren zur Herstellung von CS-Partikeln und Mikrokapseln unter Verwendung poröser Template sowie CS-Partikel und Mikrokapseln
DE102004019241A1 (de) * 2004-04-16 2005-11-03 Cellmed Ag Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie
EP1595534A1 (en) * 2004-05-13 2005-11-16 Universiteit Utrecht Holding B.V. Gel composition comprising charged polymers
AU2005294200A1 (en) * 2004-10-08 2006-04-20 Georgia Tech Research Corporation Microencapsulation of cells in hydrogels using electrostatic potentials
DE102004055729A1 (de) * 2004-11-18 2006-05-24 Cellmed Ag Herstellung von zwei-oder mehrschichtig aufgebauten Mikrokapseln
EP1863547B1 (en) 2005-03-11 2016-05-11 Wake Forest University Health Sciences Tissue engineered blood vessels
JP2007082485A (ja) * 2005-09-22 2007-04-05 Hitachi Plant Technologies Ltd 包括固定化担体、その製造方法、及び保管・輸送方法
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
WO2009137829A2 (en) 2008-05-09 2009-11-12 Wake Forest University Health Sciences Directed stem cell recruitment
US9205395B2 (en) * 2009-10-15 2015-12-08 Encapsys, Llc Encapsulation
EP2680862B1 (en) 2011-03-04 2016-07-20 Wake Forest University Health Sciences Encapsulated cells for hormone replacement therapy
US20140017304A1 (en) 2011-03-29 2014-01-16 Myriam Bosmans Method for encapsulated therapeutic products and uses thereof
EP2726192A4 (en) * 2011-06-29 2015-07-22 Univ Akron PACKAGING AND IMMOBILIZATION PROCESS
US11096898B2 (en) * 2018-11-16 2021-08-24 GH Care Inc. Alginate microcapsules for cell and molecular therapy that secrete bioactive immune molecules
EP4268856A4 (en) * 2020-12-28 2025-09-24 Mochida Pharm Co Ltd MULTILAYER STRUCTURE USING CHEMICALLY CROSSLINKED ALGINIC ACID

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD36655A3 (OSRAM) * 1964-06-12 1965-11-05
DE1917738B2 (de) * 1969-04-05 1980-06-26 Bayer Ag, 5090 Leverkusen Verfahren zum Einbetten bzw Umhüllen von festen oder flussigen Substanzen
GB1302275A (OSRAM) * 1970-03-26 1973-01-04
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4407957A (en) * 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.
US4439488A (en) * 1982-02-26 1984-03-27 The United States Of America As Represented By The Secretary Of Agriculture Encapsulation by entrapment within polyhydroxy polymer borates
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells

Also Published As

Publication number Publication date
JPH0150454B2 (OSRAM) 1989-10-30
CA1238273A (en) 1988-06-21
IT8567142A0 (it) 1985-02-12
DK65285A (da) 1985-08-14
AU572609B2 (en) 1988-05-12
DE3504724C2 (de) 1987-03-26
FR2559502A1 (fr) 1985-08-16
AU3857285A (en) 1985-08-22
DE3504724A1 (de) 1985-09-05
SE8500623D0 (sv) 1985-02-12
NL8500352A (nl) 1985-09-02
DK65285D0 (da) 1985-02-12
GB2153780B (en) 1987-10-21
GB2153780A (en) 1985-08-29
NO850535L (no) 1985-08-14
US4663286A (en) 1987-05-05
GB8503247D0 (en) 1985-03-13
IT8567142A1 (it) 1986-08-12
SE8500623L (sv) 1985-08-14
IT1184885B (it) 1987-10-28
CH665137A5 (de) 1988-04-29
JPS60190229A (ja) 1985-09-27
FR2559502B1 (fr) 1988-08-26

Similar Documents

Publication Publication Date Title
BE901704A (fr) Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables.
AU585377B2 (en) Controlled release pharmaceutical composition
IE40134L (en) Polymeric net
FR2624125B1 (fr) Composition de polymere/polyol, procede pour sa preparation et son application a la production de polyurethannes
EP0140544A3 (en) Method for preparation of graft polymer membranes, and anion and cation exchange membranes
ATA86885A (de) Verfahren zur herstellung lagerstabiler, schnellzerfallender pharmazeutischer wirkstoff-presslinge
ATE138263T1 (de) Herstellungsverfahren für biologisch aktives material enthaltende polymere mikrokapseln
DE3070402D1 (en) Cation exchange resin and production thereof, permselective membrane derived therefrom, and process for producing membrane
ES8302452A1 (es) "un procedimiento para preparar una capsula farmaceutica que tiene propiedades entericas".
ES8203629A1 (es) Procedimiento para la fabricacion de una membrana para dia- lisis
GR3020156T3 (en) Process for the production of purified glycolipids by the diaphragm separation method
FR2573431B1 (fr) Procede de production d'un polymere
DE3585193D1 (de) Macrophage aktivierende zusammensetzung und ein verfahren zu ihrer herstellung.
JPS57119805A (en) Catalytic membrane for hydrolysis
DE3880652D1 (de) Selektive gaspermeationsmembranen und verfahren zu ihrer herstellung.
ATE80178T1 (de) Herstellungsverfahren eines neuen proteolitischen komplexes mit erregender wirkung auf die bauchspeicheldruese, sowie dessen zootechnische verwendungen.
BR9711104B1 (pt) processo para preparar uma composição polidispersada de sacarìdeos, composição polidispersada de sacarìdeos e produto compreendendo uma composição polidispersada de sacarìdeos.
IL83218A0 (en) Manufacturing method for 2-hydroxynaphthalene-6-carboxylic acid
ES2062205T3 (es) Metodo para producir 2,2-dimetil-3-hidroxipropil-2,2-dimetil-3-hidroxipropionato.
ATE86667T1 (de) Verfahren zur herstellung traegergebundener enzyme.
BR8404193A (pt) Processo industrial para aproducao de poliois,especialmente eritritol e/ou ribitol,pela fermentacao aerobica de um agucar apropriado por moniliella tomentosa var,pollinis,e caldo de cultura contendo poliol
FR2642664B1 (fr) Procede de fabrication d'un ensemble unitaire de membranes de filtration, moule utilise et produit ainsi obtenu
BR8506933A (pt) Meio de moldagem,metodo para produzir um material de moldagem e processo para formar pecas fundidas
JPS568691A (en) Method and apparatus for continuous production of l-alanine
FR2627507B1 (fr) Procede de diminution de la viscosite des milieux en cas d'excretion de polymeres viscosifiants annexes dans les procedes de fermentation

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: DAMON BIOTECH INC.

Effective date: 19980228