BE899823A - Acide 2-(4-biphenylyl)-4-hexenoique et ses derives, doues d'une activite antiinflammatoire. - Google Patents

Acide 2-(4-biphenylyl)-4-hexenoique et ses derives, doues d'une activite antiinflammatoire.

Info

Publication number
BE899823A
BE899823A BE0/213067A BE213067A BE899823A BE 899823 A BE899823 A BE 899823A BE 0/213067 A BE0/213067 A BE 0/213067A BE 213067 A BE213067 A BE 213067A BE 899823 A BE899823 A BE 899823A
Authority
BE
Belgium
Prior art keywords
biphenylyl
derivatives
hexenoic acid
inflammatory activity
inflammatory
Prior art date
Application number
BE0/213067A
Other languages
English (en)
Inventor
A Del Vecchio
G Sestini
Original Assignee
Scharper Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scharper Spa filed Critical Scharper Spa
Publication of BE899823A publication Critical patent/BE899823A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compositions thérapeutiques douées d'une activité antiinflammatoire et analgésique, contenant comme composé actif l'acide 2-(4-biphénylyl)-4-hexénoique et/ou des dérivés de celui-ci, de formule (I) où X=H, Halogène, caractérisées par une faible toxicité et par l'absence ou un niveau minimal d'effet ulcérogène.
BE0/213067A 1983-06-03 1984-06-04 Acide 2-(4-biphenylyl)-4-hexenoique et ses derives, doues d'une activite antiinflammatoire. BE899823A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8321456A IT1212821B (it) 1983-06-03 1983-06-03 Derivati dell'acido fenil-etil-acetico ad attivita'antiinfiammatoria.

Publications (1)

Publication Number Publication Date
BE899823A true BE899823A (fr) 1984-10-01

Family

ID=11182041

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213067A BE899823A (fr) 1983-06-03 1984-06-04 Acide 2-(4-biphenylyl)-4-hexenoique et ses derives, doues d'une activite antiinflammatoire.

Country Status (9)

Country Link
US (1) US4562287A (fr)
JP (1) JPS606637A (fr)
BE (1) BE899823A (fr)
CH (1) CH659058A5 (fr)
DE (1) DE3420387A1 (fr)
FR (1) FR2547726B1 (fr)
GB (1) GB2142015B (fr)
IT (1) IT1212821B (fr)
NL (1) NL8401770A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201127A (fr) * 1982-09-10 1986-02-25 Katsuhiro Uchida Derive d'acide biphenylpropionique; methode de preparation et composition pharmaceutique qui en renferme
FR2869611B1 (fr) * 2004-05-03 2006-07-28 Merck Sante Soc Par Actions Si Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
CN102826953B (zh) * 2012-07-24 2015-05-13 烟台万润精细化工股份有限公司 一种4-(烷基-3-烯)-(氟)苯衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB847779A (en) * 1958-04-14 1960-09-14 Vismara Francesco Spa 2-(4-biphenylyl)-í¸-hexenoic acid esters thereof
DE1128851B (de) * 1959-03-04 1962-05-03 Vismara Francesco Spa Verfahren zur Herstellung von 2-(4-Diphenylyl)-?-hexensaeure
GB1091403A (en) * 1964-01-24 1967-11-15 Boots Pure Drug Co Ltd Therapeutically active phenylalkane derivatives
US3483248A (en) * 1964-12-08 1969-12-09 Warner Lambert Pharmaceutical Preparation of 2-(4-biphenylyl) butyric acid
FR2215208A1 (en) * 1973-01-12 1974-08-23 Zambeletti Spa L Basic esters of 2-phenyl -4 - alkyl-4-hexanoic acids - useful as spasmolytics

Also Published As

Publication number Publication date
GB2142015B (en) 1987-01-21
NL8401770A (nl) 1985-01-02
IT1212821B (it) 1989-11-30
CH659058A5 (de) 1986-12-31
US4562287A (en) 1985-12-31
GB2142015A (en) 1985-01-09
DE3420387A1 (de) 1984-12-06
GB8413984D0 (en) 1984-07-04
IT8321456A0 (it) 1983-06-03
JPS606637A (ja) 1985-01-14
FR2547726B1 (fr) 1986-08-29
FR2547726A1 (fr) 1984-12-28

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SCHARPER S.P.A. PER L INDUSTRIA FARMACEUTICA

Effective date: 19900630