BE897327A - Composes de peptides substitues et leurs intermediaires leur preparation et leur utilisation - Google Patents

Composes de peptides substitues et leurs intermediaires leur preparation et leur utilisation Download PDF

Info

Publication number
BE897327A
BE897327A BE0/211203A BE211203A BE897327A BE 897327 A BE897327 A BE 897327A BE 0/211203 A BE0/211203 A BE 0/211203A BE 211203 A BE211203 A BE 211203A BE 897327 A BE897327 A BE 897327A
Authority
BE
Belgium
Prior art keywords
group
hydrogen
lower alkyl
desc
page number
Prior art date
Application number
BE0/211203A
Other languages
English (en)
French (fr)
Inventor
S I Natarajan
E M Gordon
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of BE897327A publication Critical patent/BE897327A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
BE0/211203A 1982-07-19 1983-07-19 Composes de peptides substitues et leurs intermediaires leur preparation et leur utilisation BE897327A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (1)

Publication Number Publication Date
BE897327A true BE897327A (fr) 1984-01-19

Family

ID=23580391

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/211203A BE897327A (fr) 1982-07-19 1983-07-19 Composes de peptides substitues et leurs intermediaires leur preparation et leur utilisation

Country Status (21)

Country Link
JP (3) JPS5951246A (hu)
KR (1) KR840005709A (hu)
AU (1) AU1643283A (hu)
BE (1) BE897327A (hu)
CA (1) CA1244006A (hu)
CH (1) CH659475A5 (hu)
DE (1) DE3325850A1 (hu)
DK (1) DK330683A (hu)
ES (4) ES524200A0 (hu)
FI (1) FI832620A (hu)
FR (3) FR2530238B1 (hu)
GB (1) GB2123834B (hu)
GR (1) GR79602B (hu)
HU (1) HU187090B (hu)
IE (1) IE55818B1 (hu)
IL (1) IL69136A0 (hu)
IT (1) IT1163800B (hu)
NL (1) NL8302562A (hu)
PT (1) PT77045B (hu)
SE (1) SE8304031L (hu)
ZA (1) ZA834980B (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
DE3588094T2 (de) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive Derivate
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3414099A1 (en) 2017-01-10 2018-12-19 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
GR75019B (hu) * 1980-09-17 1984-07-12 Univ Miami
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides

Also Published As

Publication number Publication date
HUT34040A (en) 1985-01-28
GB2123834A (en) 1984-02-08
AU1643283A (en) 1984-01-26
FR2540866A1 (fr) 1984-08-17
FR2530238B1 (hu) 1989-06-30
JPH0526775B2 (hu) 1993-04-19
ZA834980B (en) 1984-03-28
SE8304031D0 (sv) 1983-07-18
ES8707549A1 (es) 1986-04-01
GB2123834B (en) 1986-10-22
GB8318492D0 (en) 1983-08-10
JPH0532601A (ja) 1993-02-09
IT8322114A0 (it) 1983-07-18
ES539084A0 (es) 1986-04-01
ES8504675A1 (es) 1985-04-16
PT77045A (en) 1983-08-01
GR79602B (hu) 1984-10-31
FR2540867A1 (fr) 1984-08-17
FI832620A (fi) 1984-01-20
DK330683A (da) 1984-01-20
FI832620A0 (fi) 1983-07-19
HU187090B (en) 1985-11-28
PT77045B (en) 1986-02-12
DK330683D0 (da) 1983-07-18
IT1163800B (it) 1987-04-08
ES8707550A1 (es) 1986-04-01
DE3325850A1 (de) 1984-01-19
IE831655L (en) 1984-01-19
ES539082A0 (es) 1986-05-16
SE8304031L (sv) 1984-03-30
IL69136A0 (en) 1983-10-31
IE55818B1 (en) 1991-01-30
ES539083A0 (es) 1986-04-01
ES524200A0 (es) 1985-04-16
ES8707548A1 (es) 1986-05-16
JPH0645582B2 (ja) 1994-06-15
CA1244006A (en) 1988-11-01
JPH0653713B2 (ja) 1994-07-20
CH659475A5 (fr) 1987-01-30
JPS5951246A (ja) 1984-03-24
KR840005709A (ko) 1984-11-16
NL8302562A (nl) 1984-02-16
FR2540867B1 (fr) 1987-07-31
JPH0517420A (ja) 1993-01-26
FR2530238A1 (hu) 1984-01-20

Similar Documents

Publication Publication Date Title
EP0132304B1 (en) Hydroxy substituted peptide compounds
JP3273515B2 (ja) 抗血栓剤としてのペプチドアルデヒド類
USH725H (en) Ureido amino and imino acids, compositions and methods for use
KR100408909B1 (ko) 신규펩티드유도체
CA1271596A (en) Hypotensive peptides, their preparation and their use
EP0517589B1 (fr) Dérivés de tachykinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
FR2574080A1 (fr) Esters et amides d'amino-acides en tant qu'inhibiteurs de la renine
JPS61263998A (ja) 新規なｎ−（アシルジペプチジル）−アミノグリコ−ル化合物
HU201963B (en) Process for producing heterocyclic ketones and pharmaceutical compositions comprising same as active ingredient
US4841067A (en) Novel amino acid derivatives
US4970297A (en) Transglutaminase inhibitors
WO1996041638A1 (en) Calpain inhibitors for the treatment of neurodegenerative diseases
FR2577925A1 (fr) Aminoalcanoylureido amino et imino acides et esters a substituant ester, a proprietes therapeutiques
WO2000058346A1 (fr) Derives de n-sulfonyl-dipeptides, leur preparation et leur application en therapeutique
BE897327A (fr) Composes de peptides substitues et leurs intermediaires leur preparation et leur utilisation
US4568666A (en) Carboxylalkyl peptide derivatives
EP0159156A1 (en) Hydroxy substituted ureido amino and imino acids
EP0103496A1 (en) Acylalkylaminocarbonyl substituted amino and imino acid compounds
FR2564845A1 (fr) Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique
US4552866A (en) Use of diamino alcohols as analgesic agents
US4895834A (en) Renin inhibitors III
CA2233860A1 (en) Thrombin inhibitors
US5221667A (en) Renin inhibiting peptides having an α-heteroatom amino acid at the P3 position
WO1993002667A1 (en) Pharmaceutical composition
US4670541A (en) Use of diamino alcohols as analgesic agents

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: E.R. SQUIBB & SONS INC.

Effective date: 19930731