BE889931A - Derives indoliques, leur preparation et leurs applications en tant que medicaments - Google Patents

Derives indoliques, leur preparation et leurs applications en tant que medicaments

Info

Publication number
BE889931A
BE889931A BE0/205644A BE205644A BE889931A BE 889931 A BE889931 A BE 889931A BE 0/205644 A BE0/205644 A BE 0/205644A BE 205644 A BE205644 A BE 205644A BE 889931 A BE889931 A BE 889931A
Authority
BE
Belgium
Prior art keywords
medicaments
applications
preparation
indolic derivatives
indolic
Prior art date
Application number
BE0/205644A
Other languages
English (en)
French (fr)
Inventor
I H Coates
M D Dowle
K Mills
D E Bays
C F Webb
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE889931A publication Critical patent/BE889931A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
BE0/205644A 1980-08-12 1981-08-11 Derives indoliques, leur preparation et leurs applications en tant que medicaments BE889931A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026287 1980-08-12

Publications (1)

Publication Number Publication Date
BE889931A true BE889931A (fr) 1982-02-11

Family

ID=10515411

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/205644A BE889931A (fr) 1980-08-12 1981-08-11 Derives indoliques, leur preparation et leurs applications en tant que medicaments

Country Status (5)

Country Link
US (1) US4839377A (enExample)
JP (1) JPS5759865A (enExample)
BE (1) BE889931A (enExample)
CA (1) CA1165765A (enExample)
ZA (1) ZA815541B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008033744A3 (en) * 2006-09-11 2008-08-21 Curis Inc Dna methyl transferase inhibitors containing a zinc binding moiety

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
EG19650A (en) * 1990-06-07 1995-09-30 Wellcome Found Derivatives of indol and their use for treatment of megraine
EP0592438B1 (en) * 1990-10-15 1997-08-27 Pfizer Inc. Indole derivatives
US5317103A (en) * 1991-01-15 1994-05-31 Merck Sharp & Dohme Limited Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263504B (enExample) * 1991-10-03 1995-11-21 Pfizer
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer Inc., New York 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
TW288010B (enExample) * 1992-03-05 1996-10-11 Pfizer
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
PL172405B1 (en) 1992-04-07 1997-09-30 Pfizer Derivatives of indole
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
AU670270B2 (en) * 1992-04-10 1996-07-11 Pfizer Inc. Acylaminoindole derivatives as 5-HT1 agonists
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
TW251284B (enExample) * 1992-11-02 1995-07-11 Pfizer
JPH10503768A (ja) * 1994-08-02 1998-04-07 メルク シヤープ エンド ドーム リミテツド アゼチジン、ピロリジンおよびピペリジン誘導体
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
AU6386196A (en) * 1995-06-19 1997-01-15 Eli Lilly And Company Process for parallel synthesis of a non-peptide library
AU7261196A (en) * 1995-10-10 1997-04-30 Eli Lilly And Company N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists
BR0312175A (pt) * 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso
AU2003249582B2 (en) * 2002-06-21 2006-08-03 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
WO2004000205A2 (en) 2002-06-21 2003-12-31 Suven Life Sciences Limited Novel tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
MXPA05005700A (es) * 2002-11-28 2005-08-16 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxiindoles.
CA2509982C (en) * 2002-11-28 2011-11-08 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
KR100739987B1 (ko) * 2002-12-18 2007-07-16 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 테트라사이클릭 3-치환인돌
SI1883451T1 (sl) 2005-04-13 2011-04-29 Neuraxon Inc Substituirane indolne spojine z NOS inhibitorno aktivnostjo
AR060451A1 (es) * 2006-04-13 2008-06-18 Neuraxon Inc Compuestos de indol 1,5 y 3,6-sustituidos con actividad inhibitoria de nos
US8063094B2 (en) * 2007-02-08 2011-11-22 Boehringer Ingelheim International Gmbh Anti-cytokine heterocyclic compounds
US20090131503A1 (en) * 2007-11-16 2009-05-21 Annedi Subhash C 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity
AU2008321353A1 (en) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating visceral pain
US8673909B2 (en) 2007-11-16 2014-03-18 Neuraxon, Inc. Indole compounds and methods for treating visceral pain
KR101534136B1 (ko) * 2013-06-11 2015-07-07 이화여자대학교 산학협력단 인돌 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 5-ht6 수용체 관련 질환의 예방 또는 치료용 약학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1203195A (fr) * 1958-07-25 1960-01-15 Chimiotherapie Lab Franc Procédé de préparation d'un nouveau dérivé de la tryptamine
NL7316677A (enExample) * 1972-12-21 1974-06-25
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008033744A3 (en) * 2006-09-11 2008-08-21 Curis Inc Dna methyl transferase inhibitors containing a zinc binding moiety

Also Published As

Publication number Publication date
JPH0148896B2 (enExample) 1989-10-20
CA1165765A (en) 1984-04-17
JPS5759865A (en) 1982-04-10
US4839377A (en) 1989-06-13
ZA815541B (en) 1983-03-30

Similar Documents

Publication Publication Date Title
BE889931A (fr) Derives indoliques, leur preparation et leurs applications en tant que medicaments
FR2432511B1 (fr) Derives triazoliques, leur preparation et leur application en tant que medicaments
FI792009A7 (fi) 3-aminopropoksiaryylijohdannaisia, niiden valmistus ja niitä sisältävät farmaseuttiset koostumukset.
NL980035I2 (nl) Benzimidazolen, de bereiding daarvan en deze verbindingen bevattende geneesmiddelen.
FR2335229A1 (fr) Nouveaux derives de quinazolone, leur preparation et leur utilisation en tant que medicaments
BE889665A (fr) Benzopyranes 7-substitues, leur preparation et leur application en tant que medicaments
FI791639A7 (fi) Uusia imidatsolijohdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia valmisteita.
FR2498596B1 (fr) Nouvelles phenylalcoylamines, leur preparation et leur utilisation en tant que medicaments
IT1196411B (it) Derivati ergolinici,loro preparazione e composizioni terapeutiche che li contengono
FR2499081B1 (fr) Derives de 7-oxo-1-azabicyclo (3-2-0) hept-2-ene, leur preparation et leur application en tant que medicaments
BE878442A (fr) Derives de la n-phenyl-indoline, leur preparation et leur application comme medicaments
SE8104236L (sv) 3-aminoproxifenylderivat, deras framstellning och lekemedel innehallande dessa
FI810835A7 (fi) Uusia tioformamidijohdannaisia, niiden valmistaminen ja niitä sisältävät lääkkeet.
IT1113449B (it) Derivati della n-fenil-alanina,loro prepatazione e loro impiego come prodotti medicinali
IT8021029A0 (it) Derivati del (piridil-2)-2tetraidrotiofene, loro preparazione, e medicamenti che licontengono.
BE878019A (fr) Nouveaux derives de 6-methoxy-2-acetyl-naphtalene oxime, leur preparation et leur application en tant que medicaments
FR2352814A1 (fr) Derives d'uracile, leur preparation et leur application en tant que medicaments
FI811576A7 (fi) Sydänlääkkeinä käytettäviä aminofenyylipyridiinijohdannaisia ja niiden valmistus.
BE891899A (fr) Derives de 7-oxo-1-azabicyclo(3-2-0) hept-2-ene, leur preparation et leur application en tant que medicaments
FI792676A7 (fi) -alkyyli-o-oksibentsyyliamiini- johdannaisia, niiden valmistus ja niitä sisältäviä lääkkeitä.
BE878395A (fr) Nouveaux derives de 1,3-benzoxazine-2,4-dione, leur preparation et leur application en tant que medicaments
BE864290A (fr) Nouveaux aryl-hexafuranosides, leur preparation et leur application en tant que medicaments
IT1150362B (it) Derivati del silicio,loro preparazione e loro applicazione come medicamenti
FR2499571B1 (fr) Nouveaux derives d'apovincaminol, leur preparation et leur application en tant que medicaments
IL56617A0 (en) Benzimidazole derivatives,their manufacture and pharmaceutical compositions containing

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19910831