US4675189A
(en)
*
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
US5366734A
(en)
*
|
1981-02-16 |
1994-11-22 |
Zeneca Limited |
Continuous release pharmaceutical compositions
|
IE52535B1
(en)
*
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
DE3218150C2
(de)
*
|
1982-05-14 |
1986-09-25 |
Akzo Gmbh, 5600 Wuppertal |
Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung
|
US4489056A
(en)
*
|
1982-06-30 |
1984-12-18 |
Merck & Co., Inc. |
Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
|
AT382076B
(de)
*
|
1982-10-15 |
1987-01-12 |
Chemie Linz Ag |
Verfahren zur herstellung von presslingen mit retardierter wirkstofffreisetzung
|
CH660488A5
(en)
*
|
1982-12-17 |
1987-04-30 |
Sandoz Ag |
(Co)oligomeric hydroxycarboxylic acid derivatives, the preparation thereof, and the use thereof in pharmaceutical compositions
|
DK119884A
(da)
*
|
1983-03-18 |
1984-09-19 |
Lilly Co Eli |
Fast, cylindrisk, subkutan implantation og dens anvendelse
|
US4649042A
(en)
*
|
1984-05-31 |
1987-03-10 |
Eli Lilly And Company |
Rumen delivery device
|
US4880635B1
(en)
*
|
1984-08-08 |
1996-07-02 |
Liposome Company |
Dehydrated liposomes
|
IE58110B1
(en)
*
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
US4639458A
(en)
*
|
1985-01-22 |
1987-01-27 |
Merck & Co., Inc. |
Tablet and formulation
|
US4670248A
(en)
*
|
1985-08-15 |
1987-06-02 |
International Minerals & Chemical Corp. |
Olivine bolus
|
DE3542972A1
(de)
*
|
1985-12-05 |
1987-06-11 |
Merck Patent Gmbh |
Pharmakadepot
|
DE3543164A1
(de)
*
|
1985-12-06 |
1987-06-19 |
Gmt Medizinische Technik Gmbh |
Knochenzement
|
US4962091A
(en)
*
|
1986-05-23 |
1990-10-09 |
Syntex (U.S.A.) Inc. |
Controlled release of macromolecular polypeptides
|
US4758435A
(en)
*
|
1986-08-11 |
1988-07-19 |
American Cyanamid Company |
Estradiol implant composition and method for preparation
|
DE3710175A1
(de)
*
|
1987-02-12 |
1988-08-25 |
Hoechst Ag |
Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung
|
US5085861A
(en)
*
|
1987-03-12 |
1992-02-04 |
The Beth Israel Hospital Association |
Bioerodable implant composition comprising crosslinked biodegradable polyesters
|
US4843112A
(en)
*
|
1987-03-12 |
1989-06-27 |
The Beth Israel Hospital Association |
Bioerodable implant composition
|
US4897268A
(en)
*
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
GB2209937B
(en)
*
|
1987-09-21 |
1991-07-03 |
Depiopharm S A |
Water insoluble polypeptides
|
US4990336A
(en)
*
|
1989-02-08 |
1991-02-05 |
Biosearch, Inc. |
Sustained release dosage form
|
HU221294B1
(en)
*
|
1989-07-07 |
2002-09-28 |
Novartis Ag |
Process for producing retarde compositions containing the active ingredient in a polymeric carrier
|
JPH0374396A
(ja)
*
|
1989-08-16 |
1991-03-28 |
Mercian Corp |
抗菌性組成物
|
FR2654337B1
(fr)
*
|
1989-11-15 |
1994-08-05 |
Roussel Uclaf |
Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
|
US5198220A
(en)
*
|
1989-11-17 |
1993-03-30 |
The Procter & Gamble Company |
Sustained release compositions for treating periodontal disease
|
US5350580A
(en)
*
|
1990-03-05 |
1994-09-27 |
Minnesota Mining And Manufacturing Company |
Device and method for extended delivery of pharmacologically active agents to the ear
|
DE69004415D1
(de)
*
|
1990-03-05 |
1993-12-09 |
Minnesota Mining & Mfg |
Vorrichtung zur verzögerten Abgabe von pharmakologisch aktiven Verbindungen ins Ohr.
|
US6353030B1
(en)
|
1990-08-01 |
2002-03-05 |
Novartis Ag |
Relating to organic compounds
|
IT1243390B
(it)
*
|
1990-11-22 |
1994-06-10 |
Vectorpharma Int |
Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
|
US5275820A
(en)
*
|
1990-12-27 |
1994-01-04 |
Allergan, Inc. |
Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles
|
US6013853A
(en)
*
|
1992-02-14 |
2000-01-11 |
The University Of Texas System |
Continuous release polymeric implant carrier
|
US5876452A
(en)
*
|
1992-02-14 |
1999-03-02 |
Board Of Regents, University Of Texas System |
Biodegradable implant
|
US5296228A
(en)
*
|
1992-03-13 |
1994-03-22 |
Allergan, Inc. |
Compositions for controlled delivery of pharmaceutical compounds
|
US5518730A
(en)
|
1992-06-03 |
1996-05-21 |
Fuisz Technologies Ltd. |
Biodegradable controlled release flash flow melt-spun delivery system
|
US5922340A
(en)
|
1992-09-10 |
1999-07-13 |
Children's Medical Center Corporation |
High load formulations and methods for providing prolonged local anesthesia
|
US6080429A
(en)
*
|
1993-10-25 |
2000-06-27 |
Genentech, Inc. |
Method for drying microspheres
|
US6913767B1
(en)
|
1993-10-25 |
2005-07-05 |
Genentech, Inc. |
Compositions for microencapsulation of antigens for use as vaccines
|
US5643605A
(en)
*
|
1993-10-25 |
1997-07-01 |
Genentech, Inc. |
Methods and compositions for microencapsulation of adjuvants
|
CN1058736C
(zh)
*
|
1994-05-27 |
2000-11-22 |
北京市星辰现代控制工程研究所 |
生物降解组合物及其制备方法和应用
|
WO1996041616A1
(fr)
|
1995-06-09 |
1996-12-27 |
Euro-Celtique, S.A. |
Procedes et compositions d'anesthesie locale prolongee
|
US6270795B1
(en)
|
1995-11-09 |
2001-08-07 |
Microbiological Research Authority |
Method of making microencapsulated DNA for vaccination and gene therapy
|
JP2000500744A
(ja)
|
1995-11-09 |
2000-01-25 |
マイクロバイオロジカル リサーチ オーソリティー |
ワクチン接種および遺伝子治療のためのマイクロカプセル化dna
|
US5747060A
(en)
*
|
1996-03-26 |
1998-05-05 |
Euro-Celtique, S.A. |
Prolonged local anesthesia with colchicine
|
US5817343A
(en)
*
|
1996-05-14 |
1998-10-06 |
Alkermes, Inc. |
Method for fabricating polymer-based controlled-release devices
|
EP0954301A4
(fr)
|
1996-06-24 |
2006-03-08 |
Euro Celtique Sa |
Methodes sures d'anesthesie locale
|
US6046187A
(en)
*
|
1996-09-16 |
2000-04-04 |
Children's Medical Center Corporation |
Formulations and methods for providing prolonged local anesthesia
|
US20020182258A1
(en)
*
|
1997-01-22 |
2002-12-05 |
Zycos Inc., A Delaware Corporation |
Microparticles for delivery of nucleic acid
|
US5783567A
(en)
*
|
1997-01-22 |
1998-07-21 |
Pangaea Pharmaceuticals, Inc. |
Microparticles for delivery of nucleic acid
|
US5912225A
(en)
|
1997-04-14 |
1999-06-15 |
Johns Hopkins Univ. School Of Medicine |
Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same
|
US5962006A
(en)
*
|
1997-06-17 |
1999-10-05 |
Atrix Laboratories, Inc. |
Polymer formulation for prevention of surgical adhesions
|
EP1009390A4
(fr)
|
1997-07-02 |
2004-05-06 |
Euro Celtique Sa |
Anesthesie a effet prolonge injectee dans les interlignes articulaires et corporelles
|
AU773642C
(en)
|
1997-12-22 |
2006-04-06 |
Mundipharma Pty Limited |
Opioid agonist/antagonist combinations
|
US6375957B1
(en)
|
1997-12-22 |
2002-04-23 |
Euro-Celtique, S.A. |
Opioid agonist/opioid antagonist/acetaminophen combinations
|
AU753370B2
(en)
*
|
1998-01-23 |
2002-10-17 |
Trustees Of Tufts College |
Pharmaceutically active compounds and methods of use thereof
|
US6406719B1
(en)
|
1998-05-13 |
2002-06-18 |
Microbiological Research Authority |
Encapsulation of bioactive agents
|
GB9810236D0
(en)
|
1998-05-13 |
1998-07-08 |
Microbiological Res Authority |
Improvements relating to encapsulation of bioactive agents
|
WO1999065531A1
(fr)
|
1998-06-18 |
1999-12-23 |
Johns Hopkins University School Of Medicine |
Methodes et reactifs d'administration intramusculaire d'acides nucleiques
|
US6451335B1
(en)
|
1998-07-02 |
2002-09-17 |
Euro-Celtique S.A. |
Formulations and methods for providing prolonged local anesthesia
|
US6143314A
(en)
*
|
1998-10-28 |
2000-11-07 |
Atrix Laboratories, Inc. |
Controlled release liquid delivery compositions with low initial drug burst
|
US20050037086A1
(en)
*
|
1999-11-19 |
2005-02-17 |
Zycos Inc., A Delaware Corporation |
Continuous-flow method for preparing microparticles
|
DE60135441D1
(de)
|
2000-02-08 |
2008-10-02 |
Euro Celtique Sa |
Zusammensetzungen mit kontrollierter freisetzung, die einen opioid agonist und antagonist enthalten
|
JP2003522144A
(ja)
|
2000-02-08 |
2003-07-22 |
ユーロ−セルティーク,エス.エイ. |
オピオイドアゴニストおよびアンタゴニストを含む制御放出組成物
|
JP2003535122A
(ja)
*
|
2000-06-02 |
2003-11-25 |
ザイコス インク. |
生物活性物質のための送達システム
|
DE10031043A1
(de)
|
2000-06-26 |
2002-02-14 |
Bayer Ag |
Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
|
EP1383483A4
(fr)
*
|
2001-04-05 |
2006-08-09 |
Collagenex Pharm Inc |
Delivrance controlee de composes de tetracycline et de derives de tetracycline
|
EP1387673B1
(fr)
|
2001-05-11 |
2010-12-29 |
Endo Pharmaceuticals Inc. |
Forme posologique d'opioides a liberation prolongee empechant la consommation abusive
|
CA2451187C
(fr)
|
2001-06-22 |
2012-08-14 |
Southern Biosystems, Inc. |
Implants coaxiaux a liberation prolongee d'ordre 0
|
US20030068375A1
(en)
|
2001-08-06 |
2003-04-10 |
Curtis Wright |
Pharmaceutical formulation containing gelling agent
|
US20030044458A1
(en)
|
2001-08-06 |
2003-03-06 |
Curtis Wright |
Oral dosage form comprising a therapeutic agent and an adverse-effect agent
|
SI1414451T1
(sl)
|
2001-08-06 |
2009-10-31 |
Euro Celtique Sa |
Formulacije opioidnega agonista s sproščanja sposobnim in sekvestriranim antagonistom
|
US20030157168A1
(en)
|
2001-08-06 |
2003-08-21 |
Christopher Breder |
Sequestered antagonist formulations
|
CA2476452A1
(fr)
*
|
2002-02-15 |
2003-08-28 |
Zycos Inc. |
Procedes d'electroporation pour introduire des agents bioactifs dans des cellules
|
ES2733044T1
(es)
|
2002-04-05 |
2019-11-27 |
Mundipharma Pharmaceuticals S L |
Composición farmacéutica que contiene oxicodona y naloxona
|
EP2422775A3
(fr)
|
2002-09-20 |
2012-04-18 |
Alpharma, Inc. |
Séquestration de sous-unité et compositions et procédés associés
|
JPWO2004047550A1
(ja)
*
|
2002-11-22 |
2006-03-23 |
明治製菓株式会社 |
粒状組成物およびその製造法
|
US7658998B2
(en)
*
|
2003-01-22 |
2010-02-09 |
Alkermes Controlled Therapeutics, Inc. |
Method of preparing sustained release microparticles
|
US9445901B2
(en)
*
|
2003-03-12 |
2016-09-20 |
Deger C. Tunc |
Prosthesis with sustained release analgesic
|
CA2803922C
(fr)
|
2003-04-07 |
2015-09-15 |
Supernus Pharmaceuticals, Inc. |
Formulations de tetracyclines en dose quotidienne unique
|
TWI347201B
(en)
|
2003-04-21 |
2011-08-21 |
Euro Celtique Sa |
Pharmaceutical products,uses thereof and methods for preparing the same
|
EP1604666A1
(fr)
|
2004-06-08 |
2005-12-14 |
Euro-Celtique S.A. |
Opioides pour le traitement de la bronchopneumopathie chronique obstructive
|
HUE037643T2
(hu)
|
2004-06-12 |
2018-09-28 |
Collegium Pharmaceutical Inc |
Visszaélésre nem alkalmas gyógyszerkészítmények
|
CN1976747A
(zh)
*
|
2004-06-30 |
2007-06-06 |
帝斯曼知识产权资产管理有限公司 |
包含beta-内酰胺抗生素的产品
|
US20060253100A1
(en)
|
2004-10-22 |
2006-11-09 |
Medtronic, Inc. |
Systems and Methods to Treat Pain Locally
|
EP1702558A1
(fr)
|
2005-02-28 |
2006-09-20 |
Euro-Celtique S.A. |
Procédé et dispositif pour évaluer la fonction de l'activité intestinale
|
AU2006255097B2
(en)
|
2005-06-06 |
2012-02-09 |
Georgetown University |
Compositions and methods for lipo modeling
|
KR101324898B1
(ko)
*
|
2006-03-31 |
2013-11-04 |
루비콘 리서치 피브이티. 엘티디. |
구강 붕해 정제
|
US8323676B2
(en)
*
|
2008-06-30 |
2012-12-04 |
Abbott Cardiovascular Systems Inc. |
Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a hydrophobic drug
|
US20090258028A1
(en)
*
|
2006-06-05 |
2009-10-15 |
Abbott Cardiovascular Systems Inc. |
Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug
|
CA2655835C
(fr)
|
2006-06-19 |
2015-07-21 |
Alpharma, Inc. |
Compositions pharmaceutiques d'agonistes opioides resistants a l'abus
|
US8017237B2
(en)
|
2006-06-23 |
2011-09-13 |
Abbott Cardiovascular Systems, Inc. |
Nanoshells on polymers
|
EP2101738A2
(fr)
*
|
2006-12-21 |
2009-09-23 |
Mallinckrodt Inc. |
Comprimés à désintégration par voie orale: composition utilisée et méthode de fabrication orale
|
EP2030613A1
(fr)
*
|
2007-08-17 |
2009-03-04 |
Abbott GmbH & Co. KG |
Préparation de compositions avec essentiellement des antibiotiques macrolides intégrés non cristallins
|
CN101235156B
(zh)
*
|
2007-11-16 |
2011-04-20 |
江苏科技大学 |
一种聚乳酸/热塑性淀粉挤出吹塑薄膜及其生产方法与应用
|
US8623418B2
(en)
|
2007-12-17 |
2014-01-07 |
Alpharma Pharmaceuticals Llc |
Pharmaceutical composition
|
US8765162B2
(en)
|
2008-06-30 |
2014-07-01 |
Abbott Cardiovascular Systems Inc. |
Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same
|
UY32487A
(es)
|
2009-03-10 |
2010-06-30 |
Euro Celtique Sa |
Composiciones farmacéuticas de liberación inmediata comprendiendo oxicodona y naloxona
|
US8911766B2
(en)
*
|
2009-06-26 |
2014-12-16 |
Abbott Cardiovascular Systems Inc. |
Drug delivery compositions including nanoshells for triggered drug release
|
CA2767646C
(fr)
|
2009-07-10 |
2019-01-29 |
President And Fellows Of Harvard College |
Bloqueurs de canaux sodiques et calciques charges de maniere permanente comme agents anti-inflammatoires
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
US9295663B2
(en)
|
2010-07-14 |
2016-03-29 |
Abbott Cardiovascular Systems Inc. |
Drug coated balloon with in-situ formed drug containing microspheres
|
UA111162C2
(uk)
|
2010-08-04 |
2016-04-11 |
Флекшен Терап'Ютікс, Інк. |
Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
|
DK2826467T3
(en)
|
2010-12-22 |
2017-10-16 |
Purdue Pharma Lp |
INCLUDED, MANIPULATION-PROPOSED SLOW-DELIVERY DOSAGE FORMS
|
CN107412173A
(zh)
|
2010-12-23 |
2017-12-01 |
普渡制药公司 |
抗篡改固体口服剂型
|
CN103415285A
(zh)
|
2011-02-02 |
2013-11-27 |
雅来制药有限责任公司 |
包含阿片样激动剂和被隔离的拮抗剂的药物组合物
|
JP2014521686A
(ja)
|
2011-08-04 |
2014-08-28 |
フレクシオン セラピューティックス インコーポレイテッド |
関節痛の治療のためのコルチコステロイド
|
AU2014215478B2
(en)
|
2013-02-05 |
2018-09-13 |
Purdue Pharma L.P. |
Tamper resistant pharmaceutical formulations
|
US10751287B2
(en)
|
2013-03-15 |
2020-08-25 |
Purdue Pharma L.P. |
Tamper resistant pharmaceutical formulations
|
UA116567C2
(uk)
|
2013-07-23 |
2018-04-10 |
Євро-Селтік С.А. |
Комбінація оксикодону та налоксону для застосування в лікуванні болю у пацієнтів, які страждають від болю та захворювання, що призводить до дисбактеріозу кишечнику та/або підвищує ризик кишкової бактеріальної транслокації
|
CA2994545A1
(fr)
|
2015-08-03 |
2017-02-09 |
President And Fellows Of Harvard College |
Bloqueurs de canal d'ions charges et procedes d'utilisation
|
US10519442B2
(en)
|
2016-02-11 |
2019-12-31 |
City Of Hope |
Twist signaling inhibitor compositions and methods of using the same
|
WO2017160818A1
(fr)
|
2016-03-14 |
2017-09-21 |
Flexion Therapeutics, Inc. |
Formules d'acétonide de triamcinolone pour une douleur articulaire chez les diabétiques
|
US11779657B2
(en)
|
2016-06-10 |
2023-10-10 |
City Of Hope |
Compositions and methods for mitochondrial genome editing
|
US9737530B1
(en)
|
2016-06-23 |
2017-08-22 |
Collegium Pharmaceutical, Inc. |
Process of making stable abuse-deterrent oral formulations
|
US10646540B2
(en)
|
2016-11-18 |
2020-05-12 |
City Of Hope |
Peptide inhibitors of twist
|
US11992482B2
(en)
|
2016-12-21 |
2024-05-28 |
Rilento Pharma, Llc |
Malleable controlled release local anesthetic with hemostatic composition
|
BR112021017809A2
(pt)
|
2019-03-11 |
2021-11-23 |
Nocion Therapeutics Inc |
Bloqueadores de canais iônicos substituídos por éster e métodos para uso
|
CN113811305A
(zh)
|
2019-03-11 |
2021-12-17 |
诺西恩医疗公司 |
带电的离子通道阻滞剂及其使用方法
|
WO2020185830A1
(fr)
|
2019-03-11 |
2020-09-17 |
Nocion Therapeutics, Inc. |
Bloqueurs de canaux ioniques chargés et procédés d'utilisation
|
US10828287B2
(en)
|
2019-03-11 |
2020-11-10 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|
US10780083B1
(en)
|
2019-03-11 |
2020-09-22 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|
BR112022008575A2
(pt)
|
2019-11-06 |
2022-08-09 |
Nocion Therapeutics Inc |
Bloqueadores de canal iônico carregado e métodos para uso
|
JP7513713B2
(ja)
|
2019-11-06 |
2024-07-09 |
ノシオン セラピューティクス,インコーポレイテッド |
荷電したイオンチャンネル遮断薬および使用方法
|
AU2021236130A1
(en)
|
2020-03-11 |
2022-09-22 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|