DE3068218D1 - Controlled release formulations - Google Patents

Controlled release formulations

Info

Publication number
DE3068218D1
DE3068218D1 DE8080303200T DE3068218T DE3068218D1 DE 3068218 D1 DE3068218 D1 DE 3068218D1 DE 8080303200 T DE8080303200 T DE 8080303200T DE 3068218 T DE3068218 T DE 3068218T DE 3068218 D1 DE3068218 D1 DE 3068218D1
Authority
DE
Germany
Prior art keywords
controlled release
release formulations
formulations
controlled
release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080303200T
Other languages
English (en)
Inventor
Nelson Henry Ludwig
Earl Eugene Ose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3068218D1 publication Critical patent/DE3068218D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8080303200T 1979-09-12 1980-09-11 Controlled release formulations Expired DE3068218D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/074,684 US4293539A (en) 1979-09-12 1979-09-12 Controlled release formulations and method of treatment

Publications (1)

Publication Number Publication Date
DE3068218D1 true DE3068218D1 (en) 1984-07-19

Family

ID=22121028

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080303200T Expired DE3068218D1 (en) 1979-09-12 1980-09-11 Controlled release formulations

Country Status (15)

Country Link
US (1) US4293539A (de)
EP (1) EP0025698B1 (de)
JP (1) JPS5646822A (de)
AU (1) AU534769B2 (de)
BE (1) BE885181A (de)
CA (1) CA1158553A (de)
CH (1) CH646054A5 (de)
DE (1) DE3068218D1 (de)
FR (1) FR2464717A1 (de)
GB (1) GB2059764B (de)
IE (1) IE50197B1 (de)
IL (1) IL61027A (de)
NZ (1) NZ194899A (de)
PH (1) PH15283A (de)
ZA (1) ZA805631B (de)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US5366734A (en) * 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
DE3218150C2 (de) * 1982-05-14 1986-09-25 Akzo Gmbh, 5600 Wuppertal Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
AT382076B (de) * 1982-10-15 1987-01-12 Chemie Linz Ag Verfahren zur herstellung von presslingen mit retardierter wirkstofffreisetzung
CH660488A5 (en) * 1982-12-17 1987-04-30 Sandoz Ag (Co)oligomeric hydroxycarboxylic acid derivatives, the preparation thereof, and the use thereof in pharmaceutical compositions
DK119884A (da) * 1983-03-18 1984-09-19 Lilly Co Eli Fast, cylindrisk, subkutan implantation og dens anvendelse
US4649042A (en) * 1984-05-31 1987-03-10 Eli Lilly And Company Rumen delivery device
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4639458A (en) * 1985-01-22 1987-01-27 Merck & Co., Inc. Tablet and formulation
US4670248A (en) * 1985-08-15 1987-06-02 International Minerals & Chemical Corp. Olivine bolus
DE3542972A1 (de) * 1985-12-05 1987-06-11 Merck Patent Gmbh Pharmakadepot
DE3543164A1 (de) * 1985-12-06 1987-06-19 Gmt Medizinische Technik Gmbh Knochenzement
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US4758435A (en) * 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
DE3710175A1 (de) * 1987-02-12 1988-08-25 Hoechst Ag Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung
US5085861A (en) * 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
US4843112A (en) * 1987-03-12 1989-06-27 The Beth Israel Hospital Association Bioerodable implant composition
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
JPH0374396A (ja) * 1989-08-16 1991-03-28 Mercian Corp 抗菌性組成物
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
DE69004415D1 (de) * 1990-03-05 1993-12-09 Minnesota Mining & Mfg Vorrichtung zur verzögerten Abgabe von pharmakologisch aktiven Verbindungen ins Ohr.
US5350580A (en) * 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US6353030B1 (en) 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5275820A (en) * 1990-12-27 1994-01-04 Allergan, Inc. Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5296228A (en) * 1992-03-13 1994-03-22 Allergan, Inc. Compositions for controlled delivery of pharmaceutical compounds
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
CN1058736C (zh) * 1994-05-27 2000-11-22 北京市星辰现代控制工程研究所 生物降解组合物及其制备方法和应用
CA2195119C (en) 1995-06-09 2001-09-11 Mark Chasin Formulations and methods for providing prolonged local anesthesia
AU717113B2 (en) 1995-11-09 2000-03-16 Health Protection Agency Microencapsulated DNA for vaccination and gene therapy
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
EP0954301A4 (de) 1996-06-24 2006-03-08 Euro Celtique Sa Verfahren zur erzeugung einer sicheren lokalen anästhesie
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US5912225A (en) 1997-04-14 1999-06-15 Johns Hopkins Univ. School Of Medicine Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same
US5962006A (en) * 1997-06-17 1999-10-05 Atrix Laboratories, Inc. Polymer formulation for prevention of surgical adhesions
KR100367144B1 (ko) 1997-07-02 2003-01-14 유로-셀티크 소시에떼 아노뉨 관절과 체강(ｂｏｄｙ ｓｐａｃｅ)내에서 연장된 마취
SI1685839T1 (sl) 1997-12-22 2013-08-30 Euro-Celtique S.A. Farmacevtska oralna dozirna oblika, ki vsebuje kombinacijo opioidnega agonista in opioidnega antagonista
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
IL137445A0 (en) * 1998-01-23 2001-07-24 Tufts College Pharmaceutically active compounds and methods of use thereof
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
CA2335460A1 (en) 1998-06-18 1999-12-23 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US6451335B1 (en) 1998-07-02 2002-09-17 Euro-Celtique S.A. Formulations and methods for providing prolonged local anesthesia
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
NZ520554A (en) 2000-02-08 2005-08-26 Euro Celtique S Tamper-resistant oral opioid agonist formulations
PL357158A1 (en) 2000-02-08 2004-07-12 Euro-Celtique, S.A. Controlled-release compositions containing opioid agonist and antagonist
AU2001268159B2 (en) * 2000-06-02 2005-09-15 Eisai Inc. Delivery systems for bioactive agents
DE10031043A1 (de) 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
EP2311440A1 (de) * 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Gesteuerte Freigabe von Tetracyclinverbindungen und Tetracyclinderivaten
CN1525851A (zh) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ 抗滥用阿片样物质控释剂型
EP1408876A4 (de) 2001-06-22 2004-09-22 Durect Corp Koaxiale implantate nullter ordnung mit verlängerter freisetzung
DE60232417D1 (de) 2001-08-06 2009-07-02 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
CA2476452A1 (en) * 2002-02-15 2003-08-28 Zycos Inc. Electroporation methods for introducing bioactive agents into cells
KR20040098050A (ko) 2002-04-05 2004-11-18 유로-셀띠끄 소시에떼 아노님 옥시코돈 및 날록손을 포함하는 약제학적 제제
PT1551372T (pt) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc Subunidade de sequestração e composições e métodos relacionados
AU2003284625A1 (en) * 2002-11-22 2004-06-18 Kunimine Industries Co., Ltd. Granular composition and process for producing the same
WO2004064752A2 (en) * 2003-01-22 2004-08-05 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
ES2391385T3 (es) 2003-04-07 2012-11-23 Supernus Pharmaceuticals, Inc. Formulaciones de doxiciclinas en dosis única diaria
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (de) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit
ES2653568T3 (es) 2004-06-12 2018-02-07 Collegium Pharmaceutical, Inc. Formulaciones de fármacos para la prevención del abuso
BRPI0512963A (pt) * 2004-06-30 2008-04-22 Dsm Ip Assests Bv produto compreendendo um antibiótico de (beta)-lactama
US20060253100A1 (en) 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
EP1702558A1 (de) 2005-02-28 2006-09-20 Euro-Celtique S.A. Verfahren und Vorrichtung zur Darmtätigkeitserfassung
ATE550031T1 (de) 2005-06-06 2012-04-15 Univ Georgetown Zusammensetzungen und verfahren für die lipomodellierung
EP2001450B1 (de) * 2006-03-31 2019-01-30 Rubicon Research Private Limited Direkt komprimierbares gemisch für im mund zerfallende tabletten
US20090258028A1 (en) * 2006-06-05 2009-10-15 Abbott Cardiovascular Systems Inc. Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug
US8323676B2 (en) * 2008-06-30 2012-12-04 Abbott Cardiovascular Systems Inc. Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a hydrophobic drug
US8158156B2 (en) 2006-06-19 2012-04-17 Alpharma Pharmaceuticals, Llc Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
EP2101738A2 (de) * 2006-12-21 2009-09-23 Mallinckrodt Inc. Zusammensetzung und verfahren zur herstellung von im mund zerfallenden tabletten
EP2030613A1 (de) * 2007-08-17 2009-03-04 Abbott GmbH & Co. KG Herstellung von Zusammensetzungen mit hauptsächlich nichtkristallinen eingebetteten Makrolid-Antibiotika
CN101235156B (zh) * 2007-11-16 2011-04-20 江苏科技大学 一种聚乳酸/热塑性淀粉挤出吹塑薄膜及其生产方法与应用
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US8765162B2 (en) 2008-06-30 2014-07-01 Abbott Cardiovascular Systems Inc. Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same
EP2405915B1 (de) 2009-03-10 2018-10-24 Euro-Celtique S.A. Unmittelbare freisetzung pharmazeutischer zusammensetzungen mit oxycodon und naloxon
US8911766B2 (en) * 2009-06-26 2014-12-16 Abbott Cardiovascular Systems Inc. Drug delivery compositions including nanoshells for triggered drug release
CA3027255C (en) 2009-07-10 2022-06-21 The General Hospital Corporation Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
MY166034A (en) 2010-12-22 2018-05-21 Purdue Pharma Lp Encased tamper resistant controlled release dosage forms
JP5638151B2 (ja) 2010-12-23 2014-12-10 パーデュー、ファーマ、リミテッド、パートナーシップ 不正加工抵抗性の（ｔａｍｐｅｒｒｅｓｉｓｔａｎｔ）固形経口剤形
RU2013136350A (ru) 2011-02-02 2015-03-27 АЛФАРМА ФАРМАСЬЮТИКЭЛЗ, ЭлЭлСи Фармацевтическая композиция, содержащая опиоидный агонист и секвестрированный антагонист
EP3281631A1 (de) 2011-08-04 2018-02-14 Flexion Therapeutics, Inc. Corticosteroide zur behandlung von gelenkschmerzen
US9149533B2 (en) 2013-02-05 2015-10-06 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
NZ716267A (en) 2013-07-23 2017-05-26 Euro Celtique Sa A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
JP6833811B2 (ja) 2015-08-03 2021-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 荷電イオンチャネル遮断薬及び使用方法
US10519442B2 (en) 2016-02-11 2019-12-31 City Of Hope Twist signaling inhibitor compositions and methods of using the same
EP3429594A1 (de) 2016-03-14 2019-01-23 Flexion Therapeutics, Inc. Triamcinolonacetonid-formulierungen für gelenkschmerzen bei diabetikern
US11779657B2 (en) 2016-06-10 2023-10-10 City Of Hope Compositions and methods for mitochondrial genome editing
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
US10646540B2 (en) 2016-11-18 2020-05-12 City Of Hope Peptide inhibitors of twist
US11992482B2 (en) 2016-12-21 2024-05-28 Rilento Pharma, Llc Malleable controlled release local anesthetic with hemostatic composition
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3129089A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Ester substituted ion channel blockers and methods for use
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3129117A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Charged ion channel blockers and methods for use
EP3937945A4 (de) 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
CA3155586A1 (en) 2019-11-06 2021-05-14 Bridget M. Cole Charged ion channel blockers and methods for use
EP4054586A4 (de) 2019-11-06 2023-11-22 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
CN115279731B (zh) 2020-03-11 2024-09-13 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE562124A (de) * 1956-11-05
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3535419A (en) * 1965-12-15 1970-10-20 Syntex Corp Veterinary compositions and methods
US3507952A (en) * 1968-12-20 1970-04-21 Smithkline Corp Sustained release bolus for animal husbandry
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
AU449029B2 (en) * 1969-08-28 1974-04-17 Commonwealth Scientific And Industrial Research Organisation Device for administration to ruminants
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
US3736646A (en) * 1971-10-18 1973-06-05 American Cyanamid Co Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures
US3991766A (en) * 1973-05-31 1976-11-16 American Cyanamid Company Controlled release of medicaments using polymers from glycolic acid
US3976071A (en) * 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
US4076798A (en) * 1975-05-29 1978-02-28 American Cyanamid Company High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical composition
US4011312A (en) * 1975-06-25 1977-03-08 American Home Products Corporation Prolonged release drug form for the treatment of bovine mastitis
US3972999A (en) * 1975-06-25 1976-08-03 American Home Products Corporation (Del.) Griseofulvin dosage forms
US4118470A (en) * 1976-06-01 1978-10-03 American Cyanamid Company Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4166800A (en) * 1977-08-25 1979-09-04 Sandoz, Inc. Processes for preparation of microspheres
US4166107A (en) * 1978-07-25 1979-08-28 The United States Of America As Represented By The Secretary Of Agriculture Sustained release bolus formulations containing insect growth regulators for control of livestock pests
JPH027925B2 (de) * 1978-10-02 1990-02-21 Purdue Research Foundation

Also Published As

Publication number Publication date
AU534769B2 (en) 1984-02-16
EP0025698B1 (de) 1984-06-13
CH646054A5 (fr) 1984-11-15
JPS5646822A (en) 1981-04-28
BE885181A (fr) 1981-03-11
EP0025698A3 (en) 1981-12-02
IE50197B1 (en) 1986-03-05
NZ194899A (en) 1983-05-10
US4293539A (en) 1981-10-06
GB2059764A (en) 1981-04-29
GB2059764B (en) 1983-10-05
IE801899L (en) 1981-03-12
PH15283A (en) 1982-11-02
CA1158553A (en) 1983-12-13
ZA805631B (en) 1982-04-28
EP0025698A2 (de) 1981-03-25
FR2464717A1 (fr) 1981-03-20
IL61027A (en) 1983-10-31
FR2464717B1 (de) 1983-08-19
AU6216180A (en) 1981-03-19

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