BE880042A - 5-(2-imidazolin-2-yl)-aminopyrimidines substituees et leur procede de preparation. - Google Patents

5-(2-imidazolin-2-yl)-aminopyrimidines substituees et leur procede de preparation.

Info

Publication number
BE880042A
BE880042A BE0/198116A BE198116A BE880042A BE 880042 A BE880042 A BE 880042A BE 0/198116 A BE0/198116 A BE 0/198116A BE 198116 A BE198116 A BE 198116A BE 880042 A BE880042 A BE 880042A
Authority
BE
Belgium
Prior art keywords
aminopyrimidines
imidazolin
substituted
preparation process
preparation
Prior art date
Application number
BE0/198116A
Other languages
English (en)
French (fr)
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of BE880042A publication Critical patent/BE880042A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE0/198116A 1978-11-15 1979-11-14 5-(2-imidazolin-2-yl)-aminopyrimidines substituees et leur procede de preparation. BE880042A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2849537A DE2849537C2 (de) 1978-11-15 1978-11-15 Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
BE880042A true BE880042A (fr) 1980-05-14

Family

ID=6054732

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/198116A BE880042A (fr) 1978-11-15 1979-11-14 5-(2-imidazolin-2-yl)-aminopyrimidines substituees et leur procede de preparation.

Country Status (4)

Country Link
JP (1) JPS5592383A (pl)
BE (1) BE880042A (pl)
DE (1) DE2849537C2 (pl)
ZA (1) ZA796148B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016767A1 (de) * 1980-04-30 1981-11-05 Beiersdorf Ag, 2000 Hamburg Pyrimidylthioharnstoffe, diese enthaltende arzneimittel und deren verwendung
DE3423328A1 (de) * 1984-06-23 1986-01-02 Beiersdorf Ag, 2000 Hamburg Selbstklebendes pflaster
DE3423293C2 (de) * 1984-06-23 1995-08-24 Lohmann Therapie Syst Lts Selbstklebendes Pflaster
DE4423177A1 (de) * 1994-07-01 1996-01-04 Kali Chemie Pharma Gmbh Antihyperglykämisch wirksame Arzneimittel
DE19911371A1 (de) 1999-03-15 2000-09-21 Solvay Pharm Gmbh Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen
PL372695A1 (pl) 2002-06-19 2005-07-25 Solvay Pharmaceuticals Gmbh Środek leczniczy do leczenia chorób wymagających hamowania lub zmniejszania aktywności protein transportujących diwęglany, regulujących wartość pH
JP2009524619A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のための２−イミダゾールの使用
ATE407931T1 (de) * 2006-06-26 2008-09-15 Chemagis Ltd Verbessertes verfahren zur herstellung von moxonidine
EP2114906B1 (en) 2007-02-02 2014-08-06 F. Hoffmann-La Roche AG 2-aminooxazolines as taar1 ligands for cns disorders
ES2525229T3 (es) 2007-02-15 2014-12-19 F. Hoffmann-La Roche Ag 2-aminooxazolinas como ligandos de TAAR1
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
DE102012215896A1 (de) 2012-09-07 2014-03-13 Wörwag Pharma GmbH & Co.KG Moxonidinsynthese mit Hilfe organischer Basen
EP2738165B1 (en) 2012-12-03 2016-10-12 WÖRWAG PHARMA GmbH & Co. KG Method by means of phase transfer catalysis
EP2765131B1 (en) 2013-02-08 2016-11-23 Arevipharma GmbH Process for the production of Moxonidine
SG11201807516UA (en) 2016-03-17 2018-09-27 Hoffmann La Roche 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (fr) * 1969-08-14 1971-02-15 Beecham Group Ltd Iminazolines
BE503170A (pl) * 1975-09-02

Also Published As

Publication number Publication date
DE2849537C2 (de) 1983-03-17
ZA796148B (en) 1980-11-26
JPS5592383A (en) 1980-07-12
JPS6354714B2 (pl) 1988-10-28
DE2849537A1 (de) 1980-05-22

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Legal Events

Date Code Title Description
CCPA Application for a supplementary protection certificate

Free format text: 095C0011

CCPV Grant of a supplementary protection certificate

Free format text: 095C0011, EXPIRES:20041114

RE20 Patent expired

Owner name: BEIERSDORF - LILLY G.M.B.H.

Effective date: 19991114

CCCH Change of ownership of the supplementary protection certificate

Owner name: SOLVAY PHARMACEUTICALS G.M.B.H.

Spc suppl protection certif: 95C0011

CCCH Change of ownership of the supplementary protection certificate

Owner name: OLVAY PHARMACEUTICALS G.M.B.H.

Spc suppl protection certif: 95C0011

Filing date: 19991114

CCRE Expiry of a supplementary protection certificate

Free format text: PRODUCT NAME: MOCONIDINE-BASE; NAT. REGISTRATION NO/DATE: 410 IS 191 F3 / 19950418; FIRST REGISTRATION: DE 9953.00.00 19910123

Spc suppl protection certif: 95C0011

Filing date: 19951017

Expiry date: 19991114

Extension date: 20041114