BE880042A - 5- (2-IMIDAZOLIN-2-YL) -AMINOPYRIMIDINES SUBSTITUTED AND THEIR PREPARATION PROCESS. - Google Patents

5- (2-IMIDAZOLIN-2-YL) -AMINOPYRIMIDINES SUBSTITUTED AND THEIR PREPARATION PROCESS.

Info

Publication number
BE880042A
BE880042A BE0/198116A BE198116A BE880042A BE 880042 A BE880042 A BE 880042A BE 0/198116 A BE0/198116 A BE 0/198116A BE 198116 A BE198116 A BE 198116A BE 880042 A BE880042 A BE 880042A
Authority
BE
Belgium
Prior art keywords
aminopyrimidines
imidazolin
substituted
preparation process
preparation
Prior art date
Application number
BE0/198116A
Other languages
French (fr)
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of BE880042A publication Critical patent/BE880042A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
BE0/198116A 1978-11-15 1979-11-14 5- (2-IMIDAZOLIN-2-YL) -AMINOPYRIMIDINES SUBSTITUTED AND THEIR PREPARATION PROCESS. BE880042A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2849537A DE2849537C2 (en) 1978-11-15 1978-11-15 Substituted 5- (2-imidazolin-2-yl) aminopyrimidines, processes for their preparation and pharmaceuticals containing them

Publications (1)

Publication Number Publication Date
BE880042A true BE880042A (en) 1980-05-14

Family

ID=6054732

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/198116A BE880042A (en) 1978-11-15 1979-11-14 5- (2-IMIDAZOLIN-2-YL) -AMINOPYRIMIDINES SUBSTITUTED AND THEIR PREPARATION PROCESS.

Country Status (4)

Country Link
JP (1) JPS5592383A (en)
BE (1) BE880042A (en)
DE (1) DE2849537C2 (en)
ZA (1) ZA796148B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016767A1 (en) * 1980-04-30 1981-11-05 Beiersdorf Ag, 2000 Hamburg PYRIMIDYLTHIOUROSES, THE MEDICINES CONTAINING THEM AND THEIR USE
DE3423328A1 (en) * 1984-06-23 1986-01-02 Beiersdorf Ag, 2000 Hamburg SELF-ADHESIVE PLASTER
DE3423293C2 (en) * 1984-06-23 1995-08-24 Lohmann Therapie Syst Lts Self-adhesive plaster
DE4423177A1 (en) * 1994-07-01 1996-01-04 Kali Chemie Pharma Gmbh Antihyperglycemic drugs
DE19911371A1 (en) 1999-03-15 2000-09-21 Solvay Pharm Gmbh Medicines for the treatment of functional disorders and diseases of the lower intestinal tract, in particular associated abdominal visceral pain
WO2004000312A2 (en) 2002-06-19 2003-12-31 Solvay Pharmaceuticals Gmbh Medicament for the treatment of diseases requiring inhibition or a reduction in the activity of ph value-regulating bicarbonate transporter proteins
CA2637292A1 (en) * 2006-01-27 2007-08-16 F. Hoffmann-La Roche Ag Use of 2-imidazoles for the treatment of cns disorders
ATE520685T1 (en) * 2006-06-26 2011-09-15 Chemagis Ltd IMPROVED METHOD FOR PRODUCING MOXONIDINE
BRPI0806940A2 (en) 2007-02-02 2014-05-06 Hoffmann La Roche 2-AMINO-OXAZOLINES AS TAAR1 LEADERS FOR CNS DISORDERS
CN101616902B (en) 2007-02-15 2013-03-27 弗·哈夫曼-拉罗切有限公司 2-aminooxazolines as TAAR1 ligands
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
DE102012215896A1 (en) 2012-09-07 2014-03-13 Wörwag Pharma GmbH & Co.KG Moxonidine synthesis using organic bases
ES2608004T3 (en) 2012-12-03 2017-04-05 WÖRWAG PHARMA GmbH & Co. KG Method by phase transfer catalysis
EP2765131B1 (en) 2013-02-08 2016-11-23 Arevipharma GmbH Process for the production of Moxonidine
RS60825B1 (en) 2016-03-17 2020-10-30 Hoffmann La Roche 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (en) * 1969-08-14 1971-02-15 Beecham Group Ltd IMINAZOLINES
BE503170A (en) * 1975-09-02

Also Published As

Publication number Publication date
DE2849537A1 (en) 1980-05-22
JPS5592383A (en) 1980-07-12
ZA796148B (en) 1980-11-26
JPS6354714B2 (en) 1988-10-28
DE2849537C2 (en) 1983-03-17

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Legal Events

Date Code Title Description
CCPA Application for a supplementary protection certificate

Free format text: 095C0011

CCPV Grant of a supplementary protection certificate

Free format text: 095C0011, EXPIRES:20041114

RE20 Patent expired

Owner name: BEIERSDORF - LILLY G.M.B.H.

Effective date: 19991114

CCCH Change of ownership of the supplementary protection certificate

Owner name: SOLVAY PHARMACEUTICALS G.M.B.H.

Spc suppl protection certif: 95C0011

CCCH Change of ownership of the supplementary protection certificate

Owner name: OLVAY PHARMACEUTICALS G.M.B.H.

Spc suppl protection certif: 95C0011

Filing date: 19991114

CCRE Expiry of a supplementary protection certificate

Free format text: PRODUCT NAME: MOCONIDINE-BASE; NAT. REGISTRATION NO/DATE: 410 IS 191 F3 / 19950418; FIRST REGISTRATION: DE 9953.00.00 19910123

Spc suppl protection certif: 95C0011

Filing date: 19951017

Expiry date: 19991114

Extension date: 20041114