BE833787A - Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique - Google Patents

Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique

Info

Publication number
BE833787A
BE833787A BE160345A BE160345A BE833787A BE 833787 A BE833787 A BE 833787A BE 160345 A BE160345 A BE 160345A BE 160345 A BE160345 A BE 160345A BE 833787 A BE833787 A BE 833787A
Authority
BE
Belgium
Prior art keywords
benzothiepin
dihydro
preparation
carboxylic acid
new amides
Prior art date
Application number
BE160345A
Other languages
English (en)
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE833787A publication Critical patent/BE833787A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE160345A 1974-09-26 1975-09-25 Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique BE833787A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50952474A 1974-09-26 1974-09-26
US58514775A 1975-06-09 1975-06-09
US74320876A 1976-11-18 1976-11-18
US05/854,176 US4185109A (en) 1974-09-26 1977-11-23 1-Benzothiepin-4-carboxamides

Publications (1)

Publication Number Publication Date
BE833787A true BE833787A (fr) 1976-03-25

Family

ID=27504481

Family Applications (1)

Application Number Title Priority Date Filing Date
BE160345A BE833787A (fr) 1974-09-26 1975-09-25 Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique

Country Status (10)

Country Link
US (1) US4185109A (show.php)
AT (1) AT346338B (show.php)
AU (1) AU496764B2 (show.php)
BE (1) BE833787A (show.php)
CA (1) CA1066279A (show.php)
CH (3) CH617433A5 (show.php)
DE (1) DE2542329C2 (show.php)
FR (1) FR2285872A1 (show.php)
NL (1) NL7511316A (show.php)
SE (1) SE420725B (show.php)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242266A (en) * 1974-09-26 1980-12-30 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxylic acid derivatives
US4277484A (en) * 1978-09-20 1981-07-07 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxamides
US4582850A (en) * 1985-02-28 1986-04-15 Ciba-Geigy Corporation Topical and systemic treatment of psoriasis using 7-chloro-N-(3,4-dichlorophenyl)-2,3-dihydro-5-hydroxy-1-benzothiepin-4-carboxamide 1,1-dioxide and pharmaceutically acceptable salts thereof
US4803197A (en) * 1987-01-12 1989-02-07 Ciba-Geigy Corporation 2,1-benzothiazepine-2,2-dioxide-5-carboxylic acid derivatives
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
EP1354604A1 (en) * 1998-12-23 2003-10-22 G.D. Searle LLC. Combinations for cardiovascular indications
EP1140185B1 (en) 1998-12-23 2003-06-04 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
ES2200588T3 (es) 1998-12-23 2004-03-01 G.D. Searle Llc Combinacion de inhibidores del transporte de oxido biliar ileal y de derivados de acido fibrico para indicaciones cardiovasculares.
PL348508A1 (en) 1998-12-23 2002-05-20 Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
NZ512534A (en) * 1998-12-23 2003-11-28 G Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
PT1140184E (pt) 1998-12-23 2003-10-31 Searle Llc Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com derivados de acido nicotinico para indicacoes cardiovasculares
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
DK1140190T3 (da) * 1998-12-23 2002-12-23 Searle Llc Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer
AU2001247331A1 (en) * 2000-03-10 2001-09-24 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
WO2001068637A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
US6740663B2 (en) * 2001-11-02 2004-05-25 G.D. Searle, Llc Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
BR112014010228B1 (pt) 2011-10-28 2020-09-29 Lumena Pharmaceuticals Llc Uso de inibidores de reciclagem de ácido biliar para o tratamento de hipercolemia e doença hepática colestática
JP6217938B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3389144A (en) * 1965-06-08 1968-06-18 Mcneilab Inc 5-pyridyl-2, 3, 4, 5-tetrahydrobenzothiepin-5-ols
US3287370A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Tetrahydrobenzothiepins
US3287368A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Dihydrobenzothiepin-5(2h)-one oximes
US3444176A (en) * 1967-04-28 1969-05-13 Mcneilab Inc Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof
US3505355A (en) * 1968-08-12 1970-04-07 Mcneilab Inc Certain dihydrobenzo-thiepin-5(2h)-ones
DE2264938A1 (de) * 1971-07-15 1975-06-12 Warner Lambert Co 3-arylaminocarbonyl-4-hydroxy-benzo eckige klammer auf b eckige klammer zu thiacyclohex(3)en-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US3826791A (en) * 1972-04-28 1974-07-30 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide and process for their production
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
US3828055A (en) * 1972-04-28 1974-08-06 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide
US3962261A (en) * 1974-02-04 1976-06-08 Warner-Lambert Company 2,3,4,5-tetra hydro-5-oxo-1-benzothiepi n-4-carboxamide 1,1-dioxides

Also Published As

Publication number Publication date
DE2542329C2 (de) 1984-05-24
CH617433A5 (show.php) 1980-05-30
CH623580A5 (show.php) 1981-06-15
SE420725B (sv) 1981-10-26
FR2285872A1 (fr) 1976-04-23
DE2542329A1 (de) 1976-04-15
CH623581A5 (show.php) 1981-06-15
AU8514875A (en) 1977-03-31
SE7510196L (sv) 1976-03-29
CA1066279A (en) 1979-11-13
NL7511316A (nl) 1976-03-30
ATA734175A (de) 1978-03-15
AU496764B2 (en) 1978-10-26
US4185109A (en) 1980-01-22
AT346338B (de) 1978-11-10
FR2285872B1 (show.php) 1978-11-10

Similar Documents

Publication Publication Date Title
FR2285872A1 (fr) Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique
RO68925A (ro) Procedeu pentru prepararea unor derivati de acid fenoxiacetic
FR2296639A1 (fr) Procede de preparation de l'acide 7-d-(-)a-amino-a-(p-hydroxyphenylacetamido)-desacetoxycephalosporanique
FR2286817A1 (fr) Procede de preparation d'acide 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetique
BE823901A (fr) Procede de preparation d'acide p-nitrobenzoique
FR2288742A1 (fr) Procede de preparation d'isochromannes
RO69916A (ro) Procedeu pentru prepararea nitrilu.ui acidului 3,7-dimetiloct-2-en-1-oic
FR2288078A1 (fr) Procede de preparation de l'acide 3-hydroxy-2-naphtoique
RO63501A (fr) Procede pour la preparation d'acide 3-cetoglutarique
FR2281892A1 (fr) Procede de defluoration d'acide phosphorique
FR2316232A1 (fr) Procede de preparation d'acide 5-alcoyl-picolique
FR2295952A1 (fr) Procede de preparation d'acide 3,6-dichloropicolinique
BE830469A (fr) Procede de preparation d'acetoxybutanal
BE815214A (fr) Procede de preparation d'acide 3-acetamido-5-amino-2
BE824582A (fr) Procede de preparation de l'acide 1h-tetrazole-1-acetique
BE817021A (fr) Procede de preparation d'acide phenyl-2 ethylenephosphonique
FR2300568A1 (fr) Procede de preparation de nouveaux derives de l'acide 5-carboxyalcoyle-2-iminobarbiturique
FR2295024A1 (fr) Procede de preparation d'a-oxothiodimethylamides
FR2273791A1 (fr) Procede de preparation d'acide hydroxy-2 naphtalene-carboxylique-3
BE825524R (fr) Procede de preparation de l'acide 3-hydroxy-2-naphtoique
RO64271A (fr) Procede pour la preparation des derives d'acide thiazolidin-4-one-2-acetique
FR2283119A1 (fr) Procede de preparation de l'acide tiglique
FR2312488A1 (fr) Procede de production d'acide trans-4-aminomethyl-cyclohexane-1-carboxylique
RO65698A2 (fr) Procede de preparation d'acide 5-ethyle-5-sec-butyle-2-thiobarbiturique
FR2295006A1 (fr) Procede de production de l'acide tartrique

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: CIBA-GEIGY A.G.

Effective date: 19880930