BE533938A - - Google Patents
Info
- Publication number
- BE533938A BE533938A BE533938DA BE533938A BE 533938 A BE533938 A BE 533938A BE 533938D A BE533938D A BE 533938DA BE 533938 A BE533938 A BE 533938A
- Authority
- BE
- Belgium
- Prior art keywords
- pharmaceutical compositions
- compositions according
- oil
- formula
- pharmaceutical
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- UHXOHOCDWYCFTC-UHFFFAOYSA-N CCOC(=O)C1=CC(C(=O)OCC)=CC=C1C1=CCSS1 Chemical compound CCOC(=O)C1=CC(C(=O)OCC)=CC=C1C1=CCSS1 UHXOHOCDWYCFTC-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 201000008827 tuberculosis Diseases 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 8
- DNJIEGIFACGWOD-UHFFFAOYSA-N Ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 claims description 6
- 239000000546 pharmaceutic aid Substances 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 239000007859 condensation product Substances 0.000 claims description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 5
- 235000019483 Peanut oil Nutrition 0.000 claims description 4
- IYFATESGLOUGBX-NDUCAMMLSA-N [2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-NDUCAMMLSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 239000000312 peanut oil Substances 0.000 claims description 4
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 4
- 229940031953 sorbitan monopalmitate Drugs 0.000 claims description 4
- 235000011071 sorbitan monopalmitate Nutrition 0.000 claims description 4
- 239000001570 sorbitan monopalmitate Substances 0.000 claims description 4
- 235000019489 Almond oil Nutrition 0.000 claims description 3
- 229940063655 Aluminum stearate Drugs 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 239000008168 almond oil Substances 0.000 claims description 3
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims description 3
- 230000036760 body temperature Effects 0.000 claims description 3
- 235000019868 cocoa butter Nutrition 0.000 claims description 3
- 229940110456 cocoa butter Drugs 0.000 claims description 3
- 239000003240 coconut oil Substances 0.000 claims description 3
- 235000019864 coconut oil Nutrition 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 235000019198 oils Nutrition 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 238000007911 parenteral administration Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000008159 sesame oil Substances 0.000 claims description 3
- 235000011803 sesame oil Nutrition 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- NTDQQZYCCIDJRK-UHFFFAOYSA-N 4-octylphenol Chemical compound CCCCCCCCC1=CC=C(O)C=C1 NTDQQZYCCIDJRK-UHFFFAOYSA-N 0.000 claims description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 2
- 235000013871 bee wax Nutrition 0.000 claims description 2
- 239000012166 beeswax Substances 0.000 claims description 2
- 229960000541 cetyl alcohol Drugs 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- 230000003000 nontoxic Effects 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- -1 thioethyl ester Chemical class 0.000 description 4
- 238000009835 boiling Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000008174 sterile solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N Thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- 201000009910 diseases by infectious agent Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- PLPFTLXIQQYOMW-UHFFFAOYSA-N 5-chlorobenzene-1,3-dicarboxylic acid Chemical compound OC(=O)C1=CC(Cl)=CC(C(O)=O)=C1 PLPFTLXIQQYOMW-UHFFFAOYSA-N 0.000 description 1
- VMZJDVIYDDYQBW-UHFFFAOYSA-N ClC1C=C(SS1)C1=CC=C(C=C1C(=O)OCC)C(=O)OCC Chemical compound ClC1C=C(SS1)C1=CC=C(C=C1C(=O)OCC)C(=O)OCC VMZJDVIYDDYQBW-UHFFFAOYSA-N 0.000 description 1
- QQVIHTHCMHWDBS-UHFFFAOYSA-N Isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 1
- CLLFSXKJTCXIHQ-UHFFFAOYSA-N NC1C=C(SS1)C1=CC=C(C=C1C(=O)OCC)C(=O)OCC Chemical compound NC1C=C(SS1)C1=CC=C(C=C1C(=O)OCC)C(=O)OCC CLLFSXKJTCXIHQ-UHFFFAOYSA-N 0.000 description 1
- XXGYPAUCQNNLGW-UHFFFAOYSA-N [N+](=O)([O-])C1C=C(SS1)C1=CC=C(C=C1C(=O)OCC)C(=O)OCC Chemical compound [N+](=O)([O-])C1C=C(SS1)C1=CC=C(C=C1C(=O)OCC)C(=O)OCC XXGYPAUCQNNLGW-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012230 colorless oil Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 230000000087 stabilizing Effects 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE533938A true BE533938A (sv) |
Family
ID=165477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE533938D BE533938A (sv) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE533938A (sv) |
-
0
- BE BE533938D patent/BE533938A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH628344A5 (fr) | Procede de preparation de nouveaux derives du piperidyl-indole et de leurs sels. | |
| EP0551230A1 (fr) | Dérivés 2-cyano 3-hydroxy énamides, leur procédé de préparation, leur application comme médicaments, les compositions pharmaceutiques les renfermant et les intermédiaires obtenus | |
| FR2532844A1 (fr) | Composition pharmaceutique contenant un compose polyprenylique | |
| CA1121353A (fr) | Procede de preparation de nouvelles imidazoquinoxalines et de leurs sels | |
| CH648285A5 (fr) | Acides benzoyl-3-nitro-2-phenylacetiques et sels metalliques, amides et esters correspondants utiles notamment comme medicaments anti-inflammatoires, procede et composes pour leur preparation. | |
| CA2112866C (fr) | Nouveaux derives 2-cyano 3-hydroxy propenamides, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant | |
| BE533938A (sv) | ||
| EP0248736B1 (fr) | Nouveaux dérivés du benzimidazolylthiométhyl benzothiazole substituté et leurs sels, procédé de prépration, application à titre de médicaments et compositions les renfermant | |
| EP0196943A1 (fr) | Nouveaux dérivés 8-thiotétrahydroquinoléines et leurs sels | |
| CA1076583A (fr) | Procede de preparation de nouveaux derives de n-hydroxy thiazole 5-carboxamide | |
| CH629796A5 (en) | Therapeutically active compounds of 4-(2-thienylmethylamino)benzoic acid | |
| BE384405A (sv) | ||
| BE483319A (sv) | ||
| FR2532847A1 (fr) | Composition pharmaceutique comprenant a titre de principe actif le 3,7,11,15-tetramethylhexadeca-1-ene-3-ol | |
| BE517290A (sv) | ||
| BE558138A (sv) | ||
| CH275969A (fr) | Procédé de préparation d'une sulfanilamido-quinoxaline substituée. | |
| BE556211A (sv) | ||
| CH341831A (fr) | Procédé de préparation de produits de condensation de saccharides sur l'azote des N-désacétyl-alcoylthiocolchicéines | |
| BE531163A (sv) | ||
| CH292943A (fr) | Procédé de préparation d'un nouveau composé chimique à activité thérapeutique. | |
| BE562179A (sv) | ||
| FR2532845A1 (fr) | Composition pharmaceutique comprenant a titre de principe actif le docosanol | |
| BE570300A (sv) | ||
| BE510679A (sv) |