BE450587A - - Google Patents
Info
- Publication number
- BE450587A BE450587A BE450587DA BE450587A BE 450587 A BE450587 A BE 450587A BE 450587D A BE450587D A BE 450587DA BE 450587 A BE450587 A BE 450587A
- Authority
- BE
- Belgium
- Prior art keywords
- potassium
- reaction
- butyrolactone
- acids
- acid
- Prior art date
Links
- 238000000034 method Methods 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- -1 N-substituted aminocarboxylic acids Chemical class 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbamate Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 4
- 239000000155 melt Substances 0.000 description 4
- LMYRWZFENFIFIT-UHFFFAOYSA-N toluene-4-sulfonamide Chemical compound CC1=CC=C(S(N)(=O)=O)C=C1 LMYRWZFENFIFIT-UHFFFAOYSA-N 0.000 description 4
- UJOBWOGCFQCDNV-UHFFFAOYSA-N Carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 3
- 229940093912 Gynecological Sulfonamides Drugs 0.000 description 3
- 150000001342 alkaline earth metals Chemical class 0.000 description 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 229940079867 intestinal antiinfectives Sulfonamides Drugs 0.000 description 3
- 150000002596 lactones Chemical class 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229940005938 ophthalmologic antiinfectives Sulfonamides Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 150000003456 sulfonamides Chemical class 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 229940026752 topical Sulfonamides Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CFHJPEDNWULMPW-UHFFFAOYSA-N 1H-indole;potassium Chemical compound [K].C1=CC=C2NC=CC2=C1 CFHJPEDNWULMPW-UHFFFAOYSA-N 0.000 description 2
- WFTICIXFISZPCW-UHFFFAOYSA-N 9H-carbazole;potassium Chemical compound [K].C1=CC=C2C3=CC=CC=C3NC2=C1 WFTICIXFISZPCW-UHFFFAOYSA-N 0.000 description 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N Sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 150000002830 nitrogen compounds Chemical class 0.000 description 2
- 235000011118 potassium hydroxide Nutrition 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 150000003388 sodium compounds Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- YEJRWHAVMIAJKC-UHFFFAOYSA-N γ-lactone 4-hydroxy-butyric acid Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 2
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-Dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 1
- IIPAGVRUKBRFKP-UHFFFAOYSA-N 1-(sulfamoylamino)dodecane Chemical compound CCCCCCCCCCCCNS(N)(=O)=O IIPAGVRUKBRFKP-UHFFFAOYSA-N 0.000 description 1
- 229940117389 Dichlorobenzene Drugs 0.000 description 1
- 101700011618 TRIR Proteins 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Trioxopurine Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- 229940116269 Uric Acid Drugs 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002897 organic nitrogen compounds Chemical class 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 150000003112 potassium compounds Chemical class 0.000 description 1
- GDNULDIPPDQVRH-UHFFFAOYSA-N potassium;pyrrolidin-2-one Chemical compound [K].O=C1CCCN1 GDNULDIPPDQVRH-UHFFFAOYSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000012262 resinous product Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N sulfonic acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical class OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE450587A true BE450587A (cs) |
Family
ID=105632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE450587D BE450587A (cs) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE450587A (cs) |
-
0
- BE BE450587D patent/BE450587A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE1008403A4 (fr) | Procede de cristallisation d'iopamidol. | |
| BE450587A (cs) | ||
| FR2701946A1 (fr) | Procédé pour la préparation d'un aminoalcool optiquement pur. | |
| EP0069001A1 (fr) | Procédé de préparation de dérivés de la tétrahydro-5,6,7,7a 4H-thiéno (3,2-C) pyridinone-2 | |
| CA1276644C (fr) | Benzamides, leur procede de preparation et leur application dans le domaine therapeutique | |
| BE528126A (cs) | ||
| CH615921A5 (en) | Process for the preparation of 1-carbamoyl-3-(3,5-dichlorophenyl)hydantoins | |
| BE554851A (cs) | ||
| CH396030A (fr) | Procédé de préparation de la N-isopropyl-N-benzyl-hydrazine et ses sels | |
| EP0056201A1 (fr) | Nouveau procédé de préparation du N,N-diméthyl aza-1 bicyclo 2,2,2 octyl-3 -10 10H-phénothiazinesulfonamide-2 | |
| BE529556A (cs) | ||
| BE442051A (cs) | ||
| BE413785A (cs) | ||
| BE495129A (cs) | ||
| BE904929A (fr) | PROCEDE DE PREPARATION DE LA 1-(2-PIPERIDINOETHYL)-4,4-bis-(4-METHOXYPHENYL)2,5-IMIDAZOLIDINEDIONE. | |
| BE482618A (cs) | ||
| BE481598A (cs) | ||
| BE446366A (cs) | ||
| CH333723A (fr) | Procédé de fabrication d'imidazolines | |
| BE541596A (cs) | ||
| BE897948A (fr) | Nouveau derive du sulpiride son procede d'obtention et son utilisation therapeutique | |
| BE476170A (cs) | ||
| FR2530242A1 (en) | Antiinflammatory 2-phenyl:benzoxazolyl-propionic acid prepn. | |
| BE541651A (cs) | ||
| BE557023A (cs) |