BE1023340B1 - Composes - Google Patents
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- BE1023340B1 BE1023340B1 BE2015/5741A BE201505741A BE1023340B1 BE 1023340 B1 BE1023340 B1 BE 1023340B1 BE 2015/5741 A BE2015/5741 A BE 2015/5741A BE 201505741 A BE201505741 A BE 201505741A BE 1023340 B1 BE1023340 B1 BE 1023340B1
- Authority
- BE
- Belgium
- Prior art keywords
- compound
- pharmaceutically acceptable
- compounds
- formula
- composition
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| US201462079027P | 2014-11-13 | 2014-11-13 | |
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| EP3268036A1 (en) | 2015-03-10 | 2018-01-17 | GlaxoSmithKline Biologicals S.A. | Compositions and uses |
| JP6744622B2 (ja) * | 2016-06-16 | 2020-08-19 | 学校法人上智学院 | ピペリジン化合物の製造方法 |
| EP4198031A1 (en) * | 2016-08-08 | 2023-06-21 | Merck Patent GmbH | Tlr7/8 antagonists and uses thereof |
| SG11201903042VA (en) | 2016-10-14 | 2019-05-30 | Precision Biosciences Inc | Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome |
| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111788204B (zh) | 2018-02-26 | 2023-05-05 | 吉利德科学公司 | 作为hbv复制抑制剂的取代吡咯嗪化合物 |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
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| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| EP3935066A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
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| EP4069729B1 (en) | 2019-12-06 | 2025-01-22 | Precision BioSciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| TW202421168A (zh) | 2020-03-20 | 2024-06-01 | 美商基利科學股份有限公司 | 4’-c-經取代-2-鹵基-2’-去氧腺苷核苷之前藥及其製造與使用方法 |
| AU2022274607A1 (en) | 2021-05-13 | 2023-11-16 | Gilead Sciences, Inc. | COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS |
| US11999733B2 (en) | 2021-06-23 | 2024-06-04 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
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| CN118165930B (zh) * | 2024-04-16 | 2024-10-01 | 颖奕干细胞生物科技(海南)有限公司 | 一种长效维持血液中pbmc细胞的方法 |
| WO2025240243A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with bulevirtide and an inhibitory nucleic acid targeting hepatitis b virus |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
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2015
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- 2015-11-13 EP EP15797460.1A patent/EP3218377B1/en active Active
- 2015-11-13 US US15/526,345 patent/US10584125B2/en active Active
- 2015-11-13 CA CA2967248A patent/CA2967248A1/en not_active Abandoned
- 2015-11-13 BR BR112017009648A patent/BR112017009648A2/pt not_active Application Discontinuation
- 2015-11-13 BE BE2015/5741A patent/BE1023340B1/fr not_active IP Right Cessation
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2020
- 2020-01-17 US US16/745,569 patent/US10919894B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010018134A1 (en) * | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Novel adenine derivatives |
Also Published As
| Publication number | Publication date |
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| US20180291026A1 (en) | 2018-10-11 |
| JP2017533925A (ja) | 2017-11-16 |
| CN107108628A (zh) | 2017-08-29 |
| US20200223849A1 (en) | 2020-07-16 |
| MX2017006302A (es) | 2018-02-16 |
| EP3218377A1 (en) | 2017-09-20 |
| ES2917887T3 (es) | 2022-07-12 |
| US10584125B2 (en) | 2020-03-10 |
| WO2016075661A1 (en) | 2016-05-19 |
| BE1023340A1 (fr) | 2017-02-08 |
| CA2967248A1 (en) | 2016-05-19 |
| US10919894B2 (en) | 2021-02-16 |
| BR112017009648A2 (pt) | 2017-12-19 |
| EP3218377B1 (en) | 2022-04-13 |
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