BE1001618A4 - Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments. - Google Patents

Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments. Download PDF

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Publication number
BE1001618A4
BE1001618A4 BE8700830A BE8700830A BE1001618A4 BE 1001618 A4 BE1001618 A4 BE 1001618A4 BE 8700830 A BE8700830 A BE 8700830A BE 8700830 A BE8700830 A BE 8700830A BE 1001618 A4 BE1001618 A4 BE 1001618A4
Authority
BE
Belgium
Prior art keywords
phe
boc
group
isobutyl
val
Prior art date
Application number
BE8700830A
Other languages
English (en)
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1001618A4 publication Critical patent/BE1001618A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
BE8700830A 1986-08-06 1987-07-27 Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments. BE1001618A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868619182A GB8619182D0 (en) 1986-08-06 1986-08-06 Peptides & derivatives

Publications (1)

Publication Number Publication Date
BE1001618A4 true BE1001618A4 (fr) 1989-12-19

Family

ID=10602311

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700830A BE1001618A4 (fr) 1986-08-06 1987-07-27 Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments.

Country Status (7)

Country Link
JP (1) JPS6348295A (ja)
BE (1) BE1001618A4 (ja)
CH (1) CH673655A5 (ja)
DE (1) DE3725137A1 (ja)
FR (1) FR2602511A1 (ja)
GB (2) GB8619182D0 (ja)
IT (1) IT1211681B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
CA2098020C (en) * 1991-01-02 2003-10-21 Daniel Schirlin Anti-viral compounds
DE69425971T2 (de) * 1993-07-08 2001-05-23 Merrell Dow Pharma Analoge von difluoro-staton
KR100308839B1 (ko) * 1993-09-09 2002-10-04 메렐 파마슈티칼스 인크. 디플루오로 스타톤 항바이러스성 유사체
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173481A2 (en) * 1984-08-06 1986-03-05 The Upjohn Company Peptides
GB2171103A (en) * 1985-02-19 1986-08-20 Sandoz Ltd Fluorinated/chlorinated peptides
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
WO1987002675A1 (en) * 1985-11-01 1987-05-07 Pfizer Inc. Difluorocyclostatine containing polypeptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
EP0297815B1 (en) * 1987-07-01 1994-07-27 Pfizer Inc. Fluorine containing renin inhibitors
JPH10183253A (ja) * 1996-12-24 1998-07-14 Nisshin Steel Co Ltd 表面性状及び加工性に優れた冷延鋼板又は溶融めっき鋼板の製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173481A2 (en) * 1984-08-06 1986-03-05 The Upjohn Company Peptides
GB2171103A (en) * 1985-02-19 1986-08-20 Sandoz Ltd Fluorinated/chlorinated peptides
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
WO1987002675A1 (en) * 1985-11-01 1987-05-07 Pfizer Inc. Difluorocyclostatine containing polypeptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, vol. 24, no. 8, 9 avril 1985, pages 1813-1817, American Chemical Society; M.H. GELB et al.: "Fluoro ketone inhibitors of hydrolytic enzymes" *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, no. 11, novembre 1985, pages 1553-1555, American Chemical Society; S. THAISRIVONGS et al.: "Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors" *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 10, 1986, pages 2080-2087, American Chemical Society; S. THAISRIVONGS et al.: "Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues" *

Also Published As

Publication number Publication date
DE3725137A1 (de) 1988-02-11
GB2196958A (en) 1988-05-11
GB8619182D0 (en) 1986-09-17
IT1211681B (it) 1989-11-03
CH673655A5 (ja) 1990-03-30
GB2196958B (en) 1990-07-04
IT8748235A0 (it) 1987-07-28
GB8718325D0 (en) 1987-09-09
FR2602511A1 (fr) 1988-02-12
JPS6348295A (ja) 1988-02-29

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SANDOZ S.A.

Effective date: 19910731