AUPO856097A0 - Vector - Google Patents

Vector

Info

Publication number
AUPO856097A0
AUPO856097A0 AUPO8560A AUPO856097A AUPO856097A0 AU PO856097 A0 AUPO856097 A0 AU PO856097A0 AU PO8560 A AUPO8560 A AU PO8560A AU PO856097 A AUPO856097 A AU PO856097A AU PO856097 A0 AUPO856097 A0 AU PO856097A0
Authority
AU
Australia
Prior art keywords
recombinant
nucleotide sequence
methods
relates
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AUPO8560A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commonwealth Scientific and Industrial Research Organisation
Pig Research and Development Corp
Original Assignee
Commonwealth Scientific and Industrial Research Organisation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3802849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AUPO856097(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Commonwealth Scientific and Industrial Research Organisation filed Critical Commonwealth Scientific and Industrial Research Organisation
Priority to AUPO8560A priority Critical patent/AUPO856097A0/en
Publication of AUPO856097A0 publication Critical patent/AUPO856097A0/en
Assigned to COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, PIG RESEARCH AND DEVELOPMENT CORPORATION reassignment COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION Alteration of Name(s) of Applicant(s) under S113 Assignors: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Assigned to COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, PIG RESEARCH AND DEVELOPMENT CORPORATION reassignment COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION Assignment by Applicant under S 113 Assignors: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Priority to PT98938527T priority patent/PT1007088E/pt
Priority to EP07005454A priority patent/EP1825863A1/en
Priority to HK01103506.0A priority patent/HK1032755B/xx
Priority to IDW20000491A priority patent/ID24174A/id
Priority to AT98938527T priority patent/ATE357250T1/de
Priority to US09/485,512 priority patent/US7323177B1/en
Priority to EP98938527A priority patent/EP1007088B1/en
Priority to DE69837390T priority patent/DE69837390T2/de
Priority to AU87209/98A priority patent/AU757683B2/en
Priority to MXPA00001562A priority patent/MXPA00001562A/es
Priority to KR1020007001486A priority patent/KR100746524B1/ko
Priority to ES98938527T priority patent/ES2283068T3/es
Priority to DK98938527T priority patent/DK1007088T3/da
Priority to NZ503039A priority patent/NZ503039A/xx
Priority to PCT/AU1998/000648 priority patent/WO1999008706A1/en
Priority to JP2000509443A priority patent/JP4365023B2/ja
Priority to CNB98809116XA priority patent/CN100366292C/zh
Priority to BR9811184-1A priority patent/BR9811184A/pt
Priority to US11/387,026 priority patent/US7473428B2/en
Priority to CY20071100603T priority patent/CY1106565T1/el
Priority to US12/197,056 priority patent/US7785602B2/en
Priority to JP2009156467A priority patent/JP2009213495A/ja
Priority to AU2011224111A priority patent/AU2011224111A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/235—Adenoviridae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AUPO8560A 1997-08-14 1997-08-14 Vector Abandoned AUPO856097A0 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
AUPO8560A AUPO856097A0 (en) 1997-08-14 1997-08-14 Vector
PCT/AU1998/000648 WO1999008706A1 (en) 1997-08-14 1998-08-14 Recombinant porcine adenovirus vector
JP2000509443A JP4365023B2 (ja) 1997-08-14 1998-08-14 組換えブタ・アデノウイルス・ベクター
CNB98809116XA CN100366292C (zh) 1997-08-14 1998-08-14 重组的猪腺病毒载体
BR9811184-1A BR9811184A (pt) 1997-08-14 1998-08-14 Vetor de adenovìrus porcino recombinante emétodo de produzir o mesmo
AU87209/98A AU757683B2 (en) 1997-08-14 1998-08-14 Recombinant porcine adenovirus vector
ES98938527T ES2283068T3 (es) 1997-08-14 1998-08-14 Vector de adenovirus porcino recombinante.
HK01103506.0A HK1032755B (en) 1997-08-14 1998-08-14 Recombinant porcine adenovirus vector
IDW20000491A ID24174A (id) 1997-08-14 1998-08-14 Vector dari porcine adenovirus
AT98938527T ATE357250T1 (de) 1997-08-14 1998-08-14 Rekombinanter schweine adenovirus vektor
US09/485,512 US7323177B1 (en) 1997-08-14 1998-08-14 Recombinant porcine adenovirus vector
EP98938527A EP1007088B1 (en) 1997-08-14 1998-08-14 Recombinant porcine adenovirus vector
DE69837390T DE69837390T2 (de) 1997-08-14 1998-08-14 Rekombinanter schweine adenovirus vektor
PT98938527T PT1007088E (pt) 1997-08-14 1998-08-14 Vector de adenovírus porcino recombinante
MXPA00001562A MXPA00001562A (es) 1997-08-14 1998-08-14 Vector recombinante de adenovirus porcino.
KR1020007001486A KR100746524B1 (ko) 1997-08-14 1998-08-14 재조합 돼지 아데노바이러스 벡터
EP07005454A EP1825863A1 (en) 1997-08-14 1998-08-14 Recombinant porcine adenovirus vector
DK98938527T DK1007088T3 (da) 1997-08-14 1998-08-14 Rekombinant svine-adenovirusvektor
NZ503039A NZ503039A (en) 1997-08-14 1998-08-14 Recombinant porcine adenovirus vector
US11/387,026 US7473428B2 (en) 1997-08-14 2006-03-22 Recombinant porcine adenovirus vector
CY20071100603T CY1106565T1 (el) 1997-08-14 2007-05-07 Φορεας ανασυνδυασμενου αδενοϊου χοιρου
US12/197,056 US7785602B2 (en) 1997-08-14 2008-08-22 Recombinant porcine adenovirus vector
JP2009156467A JP2009213495A (ja) 1997-08-14 2009-07-01 組換えブタ・アデノウイルス・ベクター
AU2011224111A AU2011224111A1 (en) 1997-08-14 2011-09-09 Recombinant porcine adenovirus vector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPO8560A AUPO856097A0 (en) 1997-08-14 1997-08-14 Vector

Publications (1)

Publication Number Publication Date
AUPO856097A0 true AUPO856097A0 (en) 1997-09-04

Family

ID=3802849

Family Applications (2)

Application Number Title Priority Date Filing Date
AUPO8560A Abandoned AUPO856097A0 (en) 1997-08-14 1997-08-14 Vector
AU2011224111A Ceased AU2011224111A1 (en) 1997-08-14 2011-09-09 Recombinant porcine adenovirus vector

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2011224111A Ceased AU2011224111A1 (en) 1997-08-14 2011-09-09 Recombinant porcine adenovirus vector

Country Status (17)

Country Link
US (3) US7323177B1 (enExample)
EP (2) EP1825863A1 (enExample)
JP (2) JP4365023B2 (enExample)
KR (1) KR100746524B1 (enExample)
CN (1) CN100366292C (enExample)
AT (1) ATE357250T1 (enExample)
AU (2) AUPO856097A0 (enExample)
BR (1) BR9811184A (enExample)
CY (1) CY1106565T1 (enExample)
DE (1) DE69837390T2 (enExample)
DK (1) DK1007088T3 (enExample)
ES (1) ES2283068T3 (enExample)
ID (1) ID24174A (enExample)
MX (1) MXPA00001562A (enExample)
NZ (1) NZ503039A (enExample)
PT (1) PT1007088E (enExample)
WO (1) WO1999008706A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO856097A0 (en) * 1997-08-14 1997-09-04 Commonwealth Scientific And Industrial Research Organisation Vector
US6492343B1 (en) * 1998-04-15 2002-12-10 University Of Saskatchewan Porcine adenovirus type 3 genome
FR2789695B1 (fr) 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
FR2804028B1 (fr) * 2000-01-21 2004-06-04 Merial Sas Vaccins adn ameliores pour animaux de rente
WO2001083737A2 (en) * 2000-05-03 2001-11-08 University Of Guelph Porcine adenovirus type 5 vector and vaccine
WO2002031168A2 (en) * 2000-10-10 2002-04-18 Genstar Therapeutics Minimal adenoviral vector and recombinant vaccines based thereon
MY146518A (en) 2001-03-27 2012-08-15 Univ Saskatchewan Methods to culture circovirus.
WO2003013598A2 (en) * 2001-08-09 2003-02-20 Lam Dominic M K Novel vaccine compositions and methods of vaccine preparation for veterinary and human diseases
WO2003023026A1 (en) 2001-09-06 2003-03-20 Alphavax, Inc. Alphavirus replicon vector systems
JP3949520B2 (ja) * 2001-09-20 2007-07-25 独立行政法人科学技術振興機構 レギュカルチン過剰発現モデル動物
US7569217B2 (en) 2001-09-24 2009-08-04 University Of Saskatchewan Porcine adenovirus E1 and E4 regions
KR20030054139A (ko) * 2001-12-24 2003-07-02 학교법인 건국대학교 돼지 오제스키병 바이러스의 ｇＤ 유전자를 포함하는재조합 발현 벡터 및 이를 이용한 ＤＮＡ 백신
US7906311B2 (en) 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
AU2003297039B2 (en) 2002-12-13 2009-03-05 Alphavax, Inc. Multi-antigenic alphavirus replicon particles and methods
AU2003297041B2 (en) 2002-12-13 2009-02-26 Alphavax, Inc. Alphavirus particles and methods for preparation
EP1608762B1 (en) 2003-03-20 2014-01-08 Alphavax, Inc. Improved alphavirus replicons and helper constructs
PT1651666E (pt) 2003-07-11 2009-08-28 Alphavax Inc Vacinas de citomegalovírus à base de alfavírus
PT1751289E (pt) 2004-05-18 2009-03-31 Alphavax Inc Vectores de alfavirais derivados da tc-83, partículas e métodos
CN101277717A (zh) * 2005-09-09 2008-10-01 英特威国际有限公司 Pcv-2疫苗
CN101849012A (zh) * 2006-07-28 2010-09-29 联邦科学和工业研究组织 用于增加重组腺病毒载体的组织嗜性的方法和组合物
DK2947149T3 (en) 2007-06-21 2018-06-06 Alphavax Inc ALPHAVIRUS REPLICATION PARTICLES FOR USE IN VACCINATION
US20100150959A1 (en) * 2008-12-15 2010-06-17 Vectogen Pty Ltd. PCV 2-Based Methods and Compositions for the Treatment of Pigs
US20110135688A1 (en) * 2009-12-04 2011-06-09 Michael Sheppard Methods and Compositions for Increasing Titer of Recombinant Porcine Adenovirus-3 Vectors
MX2014013964A (es) * 2012-05-17 2015-03-04 Zoetis Llc Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete.
EP3107568B1 (en) * 2014-02-20 2024-03-27 Vaxart, Inc. Formulations for small intestinal delivery
KR102678401B1 (ko) 2015-06-12 2024-06-26 박사르트, 인크. Rsv 및 노로바이러스 항원들의 소장 내의 전달을 위한 제형들
UA124976C2 (uk) 2016-12-14 2021-12-22 Зоетіс Сервісіз Ллс Вакцина для захисту тварини свині від зараження вірусом prrs
CN110904127B (zh) * 2018-09-18 2024-09-20 瓦赫宁恩研究基金会 非洲猪瘟病毒疫苗
WO2022155500A1 (en) 2021-01-14 2022-07-21 Senti Biosciences, Inc. Secretable payload regulation
CN116004550A (zh) * 2022-08-03 2023-04-25 石河子大学 猪轮状病毒重组腺病毒及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4320068C1 (de) 1993-06-17 1994-12-15 Audi Ag Verfahren und Vorrichtung zur Reparatur von Fahrzeugkarosserien aus Leichtmetallteilen
CA2144040A1 (fr) * 1993-07-13 1995-01-26 Michel Perricaudet Vecteurs adenoviraux defectifs et utilisation en therapie genique
WO1996002697A1 (en) 1994-07-14 1996-02-01 Union Camp Patent Holding, Inc. Improved bleaching of high consistency lignocellulosic pulp
FR2725213B1 (fr) * 1994-10-04 1996-11-08 Rhone Poulenc Rorer Sa Vecteurs viraux et utilisation en therapie genique
ES2105984B1 (es) * 1995-11-30 1998-04-16 Iberica Cyanamid Adenovirus recombinantes que expresan antigenos del virus de la gastroenteritis porcina transmisible (vgpt) y su empleo en la formacion de vacunas.
AUPO856097A0 (en) * 1997-08-14 1997-09-04 Commonwealth Scientific And Industrial Research Organisation Vector
US6492343B1 (en) * 1998-04-15 2002-12-10 University Of Saskatchewan Porcine adenovirus type 3 genome

Also Published As

Publication number Publication date
WO1999008706A8 (en) 2000-08-10
ES2283068T3 (es) 2007-10-16
EP1825863A1 (en) 2007-08-29
EP1007088B1 (en) 2007-03-21
AU2011224111A1 (en) 2011-10-13
US7323177B1 (en) 2008-01-29
BR9811184A (pt) 2001-12-26
DK1007088T3 (da) 2007-06-04
DE69837390D1 (de) 2007-05-03
EP1007088A4 (en) 2003-01-08
CN1275084A (zh) 2000-11-29
JP4365023B2 (ja) 2009-11-18
WO1999008706A1 (en) 1999-02-25
ATE357250T1 (de) 2007-04-15
CN100366292C (zh) 2008-02-06
MXPA00001562A (es) 2004-10-14
EP1007088A1 (en) 2000-06-14
US20090226485A1 (en) 2009-09-10
KR20010022882A (ko) 2001-03-26
HK1032755A1 (zh) 2001-08-03
NZ503039A (en) 2002-09-27
KR100746524B1 (ko) 2007-08-07
JP2009213495A (ja) 2009-09-24
US7473428B2 (en) 2009-01-06
US7785602B2 (en) 2010-08-31
CY1106565T1 (el) 2012-01-25
PT1007088E (pt) 2007-05-31
ID24174A (id) 2000-07-13
JP2001514871A (ja) 2001-09-18
US20060263387A1 (en) 2006-11-23
DE69837390T2 (de) 2007-08-23

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