DE69829668D1 - Herstellung und verwendung von rekombinanten influenza a virus m2 konstruktionen und impstoffe - Google Patents
Herstellung und verwendung von rekombinanten influenza a virus m2 konstruktionen und impstoffeInfo
- Publication number
- DE69829668D1 DE69829668D1 DE69829668T DE69829668T DE69829668D1 DE 69829668 D1 DE69829668 D1 DE 69829668D1 DE 69829668 T DE69829668 T DE 69829668T DE 69829668 T DE69829668 T DE 69829668T DE 69829668 D1 DE69829668 D1 DE 69829668D1
- Authority
- DE
- Germany
- Prior art keywords
- influenza
- virus
- variants
- imports
- constructions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101900330356 Influenza A virus Matrix protein 2 Proteins 0.000 title abstract 2
- 241000856131 recombinant Influenza A viruses Species 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 208000037797 influenza A Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 241000712431 Influenza A virus Species 0.000 abstract 1
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/906,930 US6169175B1 (en) | 1997-08-06 | 1997-08-06 | Preparation and use of recombinant influenza A virus M2 construct vaccines |
US906930 | 1997-08-06 | ||
PCT/US1998/016379 WO1999028478A1 (en) | 1997-08-06 | 1998-08-06 | Preparation and use of recombinant influenza a virus m2 constructs and vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69829668D1 true DE69829668D1 (de) | 2005-05-12 |
DE69829668T2 DE69829668T2 (de) | 2006-03-09 |
Family
ID=25423243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69829668T Expired - Lifetime DE69829668T2 (de) | 1997-08-06 | 1998-08-06 | Herstellung und verwendung von rekombinanten influenza a virus m2 konstruktionen und impstoffe |
Country Status (10)
Country | Link |
---|---|
US (1) | US6169175B1 (de) |
EP (1) | EP1002093B1 (de) |
JP (1) | JP2002508153A (de) |
AT (1) | ATE292685T1 (de) |
AU (1) | AU755475B2 (de) |
CA (1) | CA2299677C (de) |
DE (1) | DE69829668T2 (de) |
ES (1) | ES2239401T3 (de) |
NZ (1) | NZ502398A (de) |
WO (1) | WO1999028478A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7731972B1 (en) * | 2000-02-04 | 2010-06-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Immunoprotective influenza antigen and its use in vaccination |
JP5132851B2 (ja) * | 1997-08-05 | 2013-01-30 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー(ヴェーイーベー・ヴェーゼットウェー) | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
DE60031874D1 (de) * | 1999-09-30 | 2006-12-28 | Univ Washington | Immunologisch relevante antigene aus herpes simplexvirus |
AU2001252458A1 (en) | 2000-05-05 | 2001-11-20 | Martin Bachmann | Molecular antigen arrays and vaccines |
US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
WO2003024481A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
AU2003223285A1 (en) * | 2002-03-13 | 2003-09-29 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
CA2489410C (en) | 2002-07-17 | 2015-01-13 | Cytos Biotechnology Ag | Molecular antigen arrays |
IN2008CN05409A (de) | 2002-07-18 | 2015-10-02 | Cytos Biotechnology Ag | |
WO2004016282A1 (en) | 2002-07-19 | 2004-02-26 | Cytos Biotechnology Ag | Vaccine compositions containing amyloid beta1-6 antigen arrays |
EP1603590A4 (de) * | 2003-03-07 | 2008-08-27 | Merck & Co Inc | Influenza-virus-vakzine |
US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
EP1606398A1 (de) | 2003-03-26 | 2005-12-21 | Cytos Biotechnology AG | Konjugat aus einem melan-a peptid und einem virusähnlichen partikel |
ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
WO2006061723A2 (en) | 2004-12-06 | 2006-06-15 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
EP1973608A1 (de) | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunstimulatorische nukleinsäure-packteilchen zur behandlung von überempfindlichkeit |
CA2638760A1 (en) | 2006-03-07 | 2007-09-13 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
US20070243587A1 (en) * | 2006-04-14 | 2007-10-18 | Healthbanks Biotech Co., Ltd. | Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus |
US8148085B2 (en) * | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
CA2655108C (en) | 2006-06-12 | 2019-05-07 | Cytos Biotechnology Ag | Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages |
CA2659592C (en) | 2006-07-14 | 2016-10-04 | Konstantin V. Pugachev | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
US20100239605A1 (en) * | 2006-09-29 | 2010-09-23 | Sanofi Pasteur Biologics Co. | Recombinant Rhinovirus Vectors |
WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
JP2011519828A (ja) | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
US8460674B2 (en) | 2009-02-07 | 2013-06-11 | University Of Washington | HSV-1 epitopes and methods for using same |
WO2010115172A2 (en) | 2009-04-03 | 2010-10-07 | University Of Washington | Antigenic peptide of hsv-2 and methods for using same |
WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
ES2682998T3 (es) | 2009-08-28 | 2018-09-24 | The Chemo-Sero-Therapeutic Research Institute | Vacuna de péptido modificado derivada de M2 de influenza |
WO2011056591A1 (en) | 2009-10-26 | 2011-05-12 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
EP3022296B1 (de) | 2013-07-15 | 2022-12-28 | Wisconsin Alumni Research Foundation | Rekombinante influenzaviren mit hohem titer und erhöhter replikation in mdck- oder vero-zellen oder eiern |
WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
JP2019510481A (ja) | 2016-02-19 | 2019-04-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ワクチン開発のための改善されたb型インフルエンザウイルス複製 |
US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
US11851648B2 (en) | 2019-02-08 | 2023-12-26 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
EP4022046A2 (de) | 2019-08-27 | 2022-07-06 | Wisconsin Alumni Research Foundation (WARF) | Rekombinante influenzaviren mit stabilisiertem ha zur replikation in eiern |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5290686A (en) | 1991-07-31 | 1994-03-01 | The United States Of America As Represented By The Department Of Health And Human Services | Expression of influenza a M2 protein in baculovirus |
-
1997
- 1997-08-06 US US08/906,930 patent/US6169175B1/en not_active Expired - Lifetime
-
1998
- 1998-08-06 NZ NZ502398A patent/NZ502398A/en unknown
- 1998-08-06 AT AT98942007T patent/ATE292685T1/de not_active IP Right Cessation
- 1998-08-06 EP EP98942007A patent/EP1002093B1/de not_active Expired - Lifetime
- 1998-08-06 JP JP2000523354A patent/JP2002508153A/ja active Pending
- 1998-08-06 WO PCT/US1998/016379 patent/WO1999028478A1/en active IP Right Grant
- 1998-08-06 CA CA2299677A patent/CA2299677C/en not_active Expired - Fee Related
- 1998-08-06 DE DE69829668T patent/DE69829668T2/de not_active Expired - Lifetime
- 1998-08-06 AU AU90150/98A patent/AU755475B2/en not_active Ceased
- 1998-08-06 ES ES98942007T patent/ES2239401T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69829668T2 (de) | 2006-03-09 |
AU9015098A (en) | 1999-06-16 |
ES2239401T3 (es) | 2005-09-16 |
EP1002093B1 (de) | 2005-04-06 |
JP2002508153A (ja) | 2002-03-19 |
EP1002093A1 (de) | 2000-05-24 |
ATE292685T1 (de) | 2005-04-15 |
US6169175B1 (en) | 2001-01-02 |
NZ502398A (en) | 2002-04-26 |
AU755475B2 (en) | 2002-12-12 |
WO1999028478A1 (en) | 1999-06-10 |
CA2299677C (en) | 2011-07-26 |
CA2299677A1 (en) | 1999-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |