AU785341B2 - Artificial intelligence system for genetic analysis - Google Patents
Artificial intelligence system for genetic analysis Download PDFInfo
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- AU785341B2 AU785341B2 AU69427/00A AU6942700A AU785341B2 AU 785341 B2 AU785341 B2 AU 785341B2 AU 69427/00 A AU69427/00 A AU 69427/00A AU 6942700 A AU6942700 A AU 6942700A AU 785341 B2 AU785341 B2 AU 785341B2
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Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Bioethics (AREA)
- Databases & Information Systems (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15125899P | 1999-08-27 | 1999-08-27 | |
| US60/151258 | 1999-08-27 | ||
| PCT/US2000/023597 WO2001016860A2 (en) | 1999-08-27 | 2000-08-28 | Artificial intelligence system for genetic analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6942700A AU6942700A (en) | 2001-03-26 |
| AU785341B2 true AU785341B2 (en) | 2007-01-25 |
Family
ID=22537965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU69427/00A Ceased AU785341B2 (en) | 1999-08-27 | 2000-08-28 | Artificial intelligence system for genetic analysis |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2899660A1 (https=) |
| JP (4) | JP2003508853A (https=) |
| AU (1) | AU785341B2 (https=) |
| CA (1) | CA2420717C (https=) |
| NZ (1) | NZ518022A (https=) |
| WO (1) | WO2001016860A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6990221B2 (en) | 1998-02-07 | 2006-01-24 | Biodiscovery, Inc. | Automated DNA array image segmentation and analysis |
| US7099502B2 (en) | 1999-10-12 | 2006-08-29 | Biodiscovery, Inc. | System and method for automatically processing microarrays |
| ATE526423T1 (de) | 2000-04-18 | 2011-10-15 | Virco Bvba | Verfahren zum messen des medikamentenwiderstands gegen hcv |
| FR2819915B1 (fr) * | 2001-01-19 | 2006-11-17 | Interactive Predictive Prevent | Procede pour traiter des donnees d'analyse biologique et systeme expert d'analyse biologique mettant en oeuvre ce procede |
| US7315784B2 (en) | 2001-02-15 | 2008-01-01 | Siemens Aktiengesellschaft | Network for evaluating data obtained in a biochip measurement device |
| JP2002318858A (ja) * | 2001-04-19 | 2002-10-31 | Toshitada Kameda | 医療計画作成支援システム及びコンピュータプログラム |
| US20020155587A1 (en) | 2001-04-20 | 2002-10-24 | Sequenom, Inc. | System and method for testing a biological sample |
| AU2002308662A1 (en) * | 2001-05-12 | 2002-11-25 | X-Mine, Inc. | Web-based genetic research apparatus |
| US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
| JP2003099624A (ja) * | 2001-09-25 | 2003-04-04 | Toyo Kohan Co Ltd | Ｄｎａ提供システム |
| EP1329835A1 (en) * | 2002-01-22 | 2003-07-23 | Genonyme GmbH | Method and system for anonymously administrating medical test results and user-enabled health risk assessment |
| JP2004069559A (ja) | 2002-08-07 | 2004-03-04 | Seiko Epson Corp | 製造システム、その制御装置、制御方法、制御システム及び制御プログラム |
| US7512496B2 (en) | 2002-09-25 | 2009-03-31 | Soheil Shams | Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays |
| EP1420248A3 (de) * | 2002-11-18 | 2004-05-26 | Schott Glas | Validiertes Design für Mikroarrays |
| US20040122708A1 (en) * | 2002-12-18 | 2004-06-24 | Avinash Gopal B. | Medical data analysis method and apparatus incorporating in vitro test data |
| US7490085B2 (en) | 2002-12-18 | 2009-02-10 | Ge Medical Systems Global Technology Company, Llc | Computer-assisted data processing system and method incorporating automated learning |
| WO2005028647A1 (ja) * | 2003-09-22 | 2005-03-31 | Kyoto University | 核酸プローブ、核酸チップ、標的核酸検出方法、薬剤スクリーニング方法、標的核酸検出装置及び遺伝子診断方法 |
| US20060004526A1 (en) * | 2004-07-01 | 2006-01-05 | Ambion, Inc. | System and method for processing results of a complex genetic test |
| US7811824B2 (en) | 2006-03-30 | 2010-10-12 | Randox Laboratories Limited | Method and apparatus for monitoring the properties of a biological or chemical sample |
| US20080131887A1 (en) | 2006-11-30 | 2008-06-05 | Stephan Dietrich A | Genetic Analysis Systems and Methods |
| GB2444410B (en) * | 2006-11-30 | 2011-08-24 | Navigenics Inc | Genetic analysis systems and methods |
| EP2186031A4 (en) * | 2007-07-23 | 2014-03-26 | Fio Corp | A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects |
| US9953137B2 (en) | 2012-07-06 | 2018-04-24 | Nant Holdings Ip, Llc | Healthcare analysis stream management |
| JP6707081B2 (ja) * | 2014-10-22 | 2020-06-10 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | 正の選択下で遺伝子を同定する方法 |
| CA2967013C (en) * | 2014-11-06 | 2023-09-05 | Ancestryhealth.Com, Llc | Predicting health outcomes |
| WO2018060365A1 (en) * | 2016-09-29 | 2018-04-05 | Koninklijke Philips N.V. | Genomic variant ranking system for clinical trial matching |
| JP6499344B2 (ja) * | 2018-03-23 | 2019-04-10 | Kddi株式会社 | 検査結果管理装置、及び検査結果管理方法 |
| CN109583289A (zh) * | 2018-09-27 | 2019-04-05 | 中国农业大学 | 蟹的性别识别方法和装置 |
| JP7143743B2 (ja) * | 2018-11-30 | 2022-09-29 | 株式会社島津製作所 | 分析システム、分析装置および情報処理方法 |
| JP6777351B2 (ja) * | 2020-05-28 | 2020-10-28 | 株式会社テンクー | プログラム、情報処理装置および情報処理方法 |
| US20230289569A1 (en) * | 2020-07-28 | 2023-09-14 | Xcoo, Inc. | Non-Transitory Computer Readable Medium, Information Processing Device, Information Processing Method, and Method for Generating Learning Model |
| CN112630173A (zh) * | 2020-12-04 | 2021-04-09 | 闪优智谱(厦门)检测科技有限公司 | 一种化学成分分析系统 |
| US20220208305A1 (en) * | 2020-12-24 | 2022-06-30 | Tempus Labs, Inc. | Artificial intelligence driven therapy curation and prioritization |
| US20230298690A1 (en) * | 2022-02-14 | 2023-09-21 | AiOnco, Inc. | Genetic information processing system with unbounded-sample analysis mechanism and method of operation thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020496A1 (en) * | 1995-12-07 | 1997-06-12 | Carbon Based Corporation | Medical diagnostic analysis system |
| WO1998026407A2 (en) * | 1996-12-12 | 1998-06-18 | Incyte Pharmaceuticals, Inc. | Database for comparing and displaying genomic information |
| WO1999005591A2 (en) * | 1997-07-25 | 1999-02-04 | Affymetrix, Inc. | Method and apparatus for providing a bioinformatics database |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5861242A (en) | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
| US5692107A (en) * | 1994-03-15 | 1997-11-25 | Lockheed Missiles & Space Company, Inc. | Method for generating predictive models in a computer system |
| US5882933A (en) * | 1995-06-08 | 1999-03-16 | Coulter International Corp. | Method for determination of leukocytes and hemoglobin concentration in blood |
| US5733729A (en) | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
| US5936078A (en) * | 1995-12-12 | 1999-08-10 | Kyowa Hakko Kogyo Co., Ltd. | DNA and protein for the diagnosis and treatment of Alzheimer's disease |
| EP0972830A4 (en) * | 1997-02-21 | 2003-02-05 | Takara Shuzo Co | GENES ASSOCIATED WITH CANCER |
| EP1027459A1 (en) * | 1997-07-14 | 2000-08-16 | Abbott Laboratories | Telemedicine |
| WO1999041373A2 (en) * | 1998-02-11 | 1999-08-19 | Incyte Pharmaceuticals, Inc. | Human transport-associated molecules |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| US6263287B1 (en) | 1998-11-12 | 2001-07-17 | Scios Inc. | Systems for the analysis of gene expression data |
-
2000
- 2000-08-28 WO PCT/US2000/023597 patent/WO2001016860A2/en not_active Ceased
- 2000-08-28 EP EP14168577.6A patent/EP2899660A1/en not_active Withdrawn
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020496A1 (en) * | 1995-12-07 | 1997-06-12 | Carbon Based Corporation | Medical diagnostic analysis system |
| WO1998026407A2 (en) * | 1996-12-12 | 1998-06-18 | Incyte Pharmaceuticals, Inc. | Database for comparing and displaying genomic information |
| WO1999005591A2 (en) * | 1997-07-25 | 1999-02-04 | Affymetrix, Inc. | Method and apparatus for providing a bioinformatics database |
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| EP1222602B1 (en) | 2015-12-09 |
| WO2001016860A2 (en) | 2001-03-08 |
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| JP2016154042A (ja) | 2016-08-25 |
| JP2011238252A (ja) | 2011-11-24 |
| JP2014096183A (ja) | 2014-05-22 |
| CA2420717A1 (en) | 2001-03-08 |
| NZ518022A (en) | 2004-01-30 |
| JP5966109B1 (ja) | 2016-08-10 |
| EP1222602A2 (en) | 2002-07-17 |
| AU6942700A (en) | 2001-03-26 |
| EP2899660A1 (en) | 2015-07-29 |
| CA2420717C (en) | 2010-07-27 |
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