CA2420717A1 - Artificial intelligence system for genetic analysis - Google Patents
Artificial intelligence system for genetic analysis Download PDFInfo
- Publication number
- CA2420717A1 CA2420717A1 CA002420717A CA2420717A CA2420717A1 CA 2420717 A1 CA2420717 A1 CA 2420717A1 CA 002420717 A CA002420717 A CA 002420717A CA 2420717 A CA2420717 A CA 2420717A CA 2420717 A1 CA2420717 A1 CA 2420717A1
- Authority
- CA
- Canada
- Prior art keywords
- information
- hybridization
- data
- facility
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000013473 artificial intelligence Methods 0.000 title claims abstract 7
- 238000012252 genetic analysis Methods 0.000 title 1
- 238000009396 hybridization Methods 0.000 claims abstract 21
- 238000000034 method Methods 0.000 claims abstract 7
- 238000003499 nucleic acid array Methods 0.000 claims abstract 5
- 230000003287 optical effect Effects 0.000 claims abstract 5
- 238000012360 testing method Methods 0.000 claims abstract 4
- 238000004458 analytical method Methods 0.000 claims abstract 2
- 230000004962 physiological condition Effects 0.000 claims 6
- 238000003745 diagnosis Methods 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 238000007405 data analysis Methods 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Bioethics (AREA)
- Databases & Information Systems (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
Abstract
The present invention provides a complete artificial intelligence system for the acquisition and analysis of nucleic acid array hybridization information . The system is divided into at least one central data processing facility and one or more user facilities, linked by encrypted network connections or similar links. Each user facility may include an optical scanning system to collect hybridization signals from a nucleic acid array, an image processing system to convert the optical data into a set of hybridization parameters, a connection to a data network, and a user interface to display, manipulate, search, and analyze hybridization information. This system reads data from a gene chip or DNA microarray, or a proteomics chip, analyzes test results bas ed on maintained parameters, evaluates patient risk for various ailments, recommends methods of treatment, presents information to medical and/or private individuals, and notifies test participants when new treatment becom es available.
Claims (24)
1. An artificial intelligence system for the analysis of nucleic acid array hybridization information, comprising:
(i) a Web server that communicates with at least one user facility, receiving and transmitting hybridization information, supporting data analyses, and providing security and business functions, (ii) a database server that stores hybridization profiles, clinical information associated with hybridization profiles, and statistical information associated with hybridization profiles; and (iii) an application server that facilitates information exchange between the Web server and the database server.
(i) a Web server that communicates with at least one user facility, receiving and transmitting hybridization information, supporting data analyses, and providing security and business functions, (ii) a database server that stores hybridization profiles, clinical information associated with hybridization profiles, and statistical information associated with hybridization profiles; and (iii) an application server that facilitates information exchange between the Web server and the database server.
2. The system of claim 1, wherein the Web server further comprises functions selected from the group consisting of product information, product ordering, company information, statistical summary of patient database, request to the application server, and security.
3. The system of claim 1, wherein the database server further comprises functions selected from the group consisting of genetic pattern database for chip ID, patient generic pattern database, and statistical data summary.
4. The system of claim 1, wherein the application server constructs at least one query for the database server, and performs at least one statistical comparison between hybridization parameters received by the Web server and hybridization parameters supplied by the database server.
5. The system of claim 4, wherein the application server further comprises functions selected from the group consisting of database query for chip ID genetic pattern, database query for statistical data summary, pattern match statistical processing, and results output.
6. The system of claim 1, wherein said artificial intelligence system further comprises an operations server.
7. The system of claim 6, wherein the operations server comprises functions selected from the group consisting of order management, billing management, and order tracking.
8. The system of claim 1, wherein the user facility is linked to said artificial intelligence system through encrypted network connections.
9. The system of claim 8, wherein the user facility is a remote user facility.
10. The system of claim 8, wherein the user facility is a local user facility.
11. The system of claim 8, wherein the user facility is selected from the group consisting of a hospital, a clinic, a research facility, a business, and a non-profit organization.
12. The system of claim 8, wherein the user facility comprises:
(i) an optical scanning system to collect hybridization signals from a nucleic acid array, (ii) an image processing system to convert optical data from the optical scanning system into a set of hybridization parameters, (iii) a computer linked to a network; and (iv) a user interface to display data related information.
(i) an optical scanning system to collect hybridization signals from a nucleic acid array, (ii) an image processing system to convert optical data from the optical scanning system into a set of hybridization parameters, (iii) a computer linked to a network; and (iv) a user interface to display data related information.
13. The system of claim 12, wherein the network is the Internet.
14. The system of claim 12, wherein the user interface further comprises functions selected from the group consisting of manipulating data, searching data, analyzing data, and displaying data.
15. The system of claim 14, wherein the user interface further comprises displayed information selected from the group consisting of user information, clinical sample information, testing information, clinical test results report, R&D
sample information, chip information, results report for biopharma chip, therapeutic choices, and billing information.
sample information, chip information, results report for biopharma chip, therapeutic choices, and billing information.
16. The system of claim 12, wherein the data related information is selected from the group consisting of hybridization information, patient information, statistical information, clinical information, medical information, diagnosis information, treatment information, biological information, product information, and company information.
17. The system of claim 12, wherein the user facility further comprises functions selected from the group consisting of generic pattern processing, request for pattern match for chip ID, and report generation.
18. The system of claim 8, wherein the user facility comprises:
(i) a computer linked to a network; and (ii) a user interface to display data related information.
(i) a computer linked to a network; and (ii) a user interface to display data related information.
19. The system of claim 18, wherein the data related information is selected from the group consisting of hybridization information, patient information, statistical information, clinical information, medical information, diagnosis information, treatment information, biological information, product information, and company information.
20. The system of claim 1, comprising a system architecture based on a shared processing functionality between at least one remote location and at least one central data processing facility.
21. A method for diagnosing a physiological condition, comprising:
(ii) collecting hybridization information from a nucleic acid array, (iii) transmitting said hybridization information to a central data processing facility, (iv) analyzing said hybridization information to generate a hybridization profile, (v) comparing said hybridization profile to stored hybridization parameters to provide analyzed data, and (vi) determining the physiological condition suggested by said analyzed data through the use of artificial intelligence.
(ii) collecting hybridization information from a nucleic acid array, (iii) transmitting said hybridization information to a central data processing facility, (iv) analyzing said hybridization information to generate a hybridization profile, (v) comparing said hybridization profile to stored hybridization parameters to provide analyzed data, and (vi) determining the physiological condition suggested by said analyzed data through the use of artificial intelligence.
22. The method of claim 21, further comprising recommending methods of treatment based on the physiological condition.
23. A method for diagnosing a physiological condition, comprising:
(ii) collecting information from a proteomics chip, (iii) transmitting said information to a central data processing facility, (iv) analyzing said information to generate a proteomics profile, (v) comparing said proteomics profile to stored proteomics parameters to provide analyzed data, and (vi) determining the physiological condition suggested by said analyzed data through the use of artificial intelligence.
(ii) collecting information from a proteomics chip, (iii) transmitting said information to a central data processing facility, (iv) analyzing said information to generate a proteomics profile, (v) comparing said proteomics profile to stored proteomics parameters to provide analyzed data, and (vi) determining the physiological condition suggested by said analyzed data through the use of artificial intelligence.
24. The method of claim 23, further comprising recommending methods of treatment based on the physiological condition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15125899P | 1999-08-27 | 1999-08-27 | |
| US60/151,258 | 1999-08-27 | ||
| PCT/US2000/023597 WO2001016860A2 (en) | 1999-08-27 | 2000-08-28 | Artificial intelligence system for genetic analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2420717A1 true CA2420717A1 (en) | 2001-03-08 |
| CA2420717C CA2420717C (en) | 2010-07-27 |
Family
ID=22537965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2420717A Expired - Fee Related CA2420717C (en) | 1999-08-27 | 2000-08-28 | Artificial intelligence system for genetic analysis |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2899660A1 (en) |
| JP (4) | JP2003508853A (en) |
| AU (1) | AU785341B2 (en) |
| CA (1) | CA2420717C (en) |
| NZ (1) | NZ518022A (en) |
| WO (1) | WO2001016860A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112630173A (en) * | 2020-12-04 | 2021-04-09 | 闪优智谱(厦门)检测科技有限公司 | Chemical composition analysis system |
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| US6990221B2 (en) | 1998-02-07 | 2006-01-24 | Biodiscovery, Inc. | Automated DNA array image segmentation and analysis |
| US7099502B2 (en) | 1999-10-12 | 2006-08-29 | Biodiscovery, Inc. | System and method for automatically processing microarrays |
| ES2373488T3 (en) | 2000-04-18 | 2012-02-06 | Virco Bvba | METHODS TO MEASURE DRUG RESISTANCE AGAINST HCV. |
| FR2819915B1 (en) * | 2001-01-19 | 2006-11-17 | Interactive Predictive Prevent | METHOD FOR PROCESSING BIOLOGICAL ANALYSIS DATA AND EXPERT SYSTEM FOR BIOLOGICAL ANALYSIS USING THE SAME |
| US7315784B2 (en) | 2001-02-15 | 2008-01-01 | Siemens Aktiengesellschaft | Network for evaluating data obtained in a biochip measurement device |
| JP2002318858A (en) * | 2001-04-19 | 2002-10-31 | Toshitada Kameda | System for supporting medical treatment program preparation and computer program |
| US20020155587A1 (en) | 2001-04-20 | 2002-10-24 | Sequenom, Inc. | System and method for testing a biological sample |
| AU2002308662A1 (en) * | 2001-05-12 | 2002-11-25 | X-Mine, Inc. | Web-based genetic research apparatus |
| US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
| JP2003099624A (en) * | 2001-09-25 | 2003-04-04 | Toyo Kohan Co Ltd | Dna providing system |
| EP1329835A1 (en) * | 2002-01-22 | 2003-07-23 | Genonyme GmbH | Method and system for anonymously administrating medical test results and user-enabled health risk assessment |
| JP2004069559A (en) | 2002-08-07 | 2004-03-04 | Seiko Epson Corp | Manufacturing system, its controller, controlling method, controlling system, and control program |
| US7512496B2 (en) | 2002-09-25 | 2009-03-31 | Soheil Shams | Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays |
| EP1420248A3 (en) * | 2002-11-18 | 2004-05-26 | Schott Glas | Validated design for microarrays |
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| EP1717313A4 (en) * | 2003-09-22 | 2007-11-14 | Univ Kyoto | Nucleic acid probe, nucleic acid chip, method of detecting target nucleic acid, method of screening drug, apparatus for detecting target nucleic acid and gene diagnosis method |
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| US7811824B2 (en) | 2006-03-30 | 2010-10-12 | Randox Laboratories Limited | Method and apparatus for monitoring the properties of a biological or chemical sample |
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| US20080131887A1 (en) | 2006-11-30 | 2008-06-05 | Stephan Dietrich A | Genetic Analysis Systems and Methods |
| SG183034A1 (en) * | 2007-07-23 | 2012-08-30 | Fio Corp | A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects |
| EP2870581B1 (en) * | 2012-07-06 | 2023-11-29 | Nant Holdings IP, LLC | Healthcare analysis stream management |
| AU2015336005B2 (en) | 2014-10-22 | 2018-07-26 | Baylor College Of Medicine | Method to identify genes under positive selection |
| WO2016073953A1 (en) * | 2014-11-06 | 2016-05-12 | Ancestryhealth.Com, Llc | Predicting health outcomes |
| US20190362807A1 (en) * | 2016-09-29 | 2019-11-28 | Koninklijke Philips N.V. | Genomic variant ranking system for clinical trial matching |
| JP6499344B2 (en) * | 2018-03-23 | 2019-04-10 | Kddi株式会社 | Inspection result management apparatus and inspection result management method |
| CN109583289A (en) * | 2018-09-27 | 2019-04-05 | 中国农业大学 | The gender identification method and device of crab |
| JP7143743B2 (en) * | 2018-11-30 | 2022-09-29 | 株式会社島津製作所 | Analysis system, analysis device and information processing method |
| JP6777351B2 (en) * | 2020-05-28 | 2020-10-28 | 株式会社テンクー | Programs, information processing equipment and information processing methods |
| US20230289569A1 (en) * | 2020-07-28 | 2023-09-14 | Xcoo, Inc. | Non-Transitory Computer Readable Medium, Information Processing Device, Information Processing Method, and Method for Generating Learning Model |
| US20220208305A1 (en) * | 2020-12-24 | 2022-06-30 | Tempus Labs, Inc. | Artificial intelligence driven therapy curation and prioritization |
| WO2023154937A1 (en) * | 2022-02-14 | 2023-08-17 | AiOnco, Inc. | Genetic information processing system with unbounded-sample analysis mechanism and method of operation thereof |
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-
2000
- 2000-08-28 AU AU69427/00A patent/AU785341B2/en not_active Ceased
- 2000-08-28 NZ NZ518022A patent/NZ518022A/en not_active IP Right Cessation
- 2000-08-28 CA CA2420717A patent/CA2420717C/en not_active Expired - Fee Related
- 2000-08-28 WO PCT/US2000/023597 patent/WO2001016860A2/en active IP Right Grant
- 2000-08-28 EP EP14168577.6A patent/EP2899660A1/en not_active Withdrawn
- 2000-08-28 JP JP2001520734A patent/JP2003508853A/en active Pending
- 2000-08-28 EP EP00957869.1A patent/EP1222602B1/en not_active Expired - Lifetime
-
2011
- 2011-06-15 JP JP2011133605A patent/JP2011238252A/en active Pending
-
2014
- 2014-02-05 JP JP2014020747A patent/JP2014096183A/en active Pending
-
2016
- 2016-04-22 JP JP2016086583A patent/JP5966109B1/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112630173A (en) * | 2020-12-04 | 2021-04-09 | 闪优智谱(厦门)检测科技有限公司 | Chemical composition analysis system |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016154042A (en) | 2016-08-25 |
| WO2001016860A2 (en) | 2001-03-08 |
| EP1222602B1 (en) | 2015-12-09 |
| JP2014096183A (en) | 2014-05-22 |
| AU785341B2 (en) | 2007-01-25 |
| JP2011238252A (en) | 2011-11-24 |
| WO2001016860A3 (en) | 2001-06-14 |
| JP5966109B1 (en) | 2016-08-10 |
| AU6942700A (en) | 2001-03-26 |
| CA2420717C (en) | 2010-07-27 |
| EP2899660A1 (en) | 2015-07-29 |
| NZ518022A (en) | 2004-01-30 |
| JP2003508853A (en) | 2003-03-04 |
| EP1222602A2 (en) | 2002-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190828 |