AU782080B2 - New process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H- pyrrolo(2,1-c)(1,2,4)benzothiadiazine - Google Patents

New process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H- pyrrolo(2,1-c)(1,2,4)benzothiadiazine Download PDF

Info

Publication number
AU782080B2
AU782080B2 AU34405/02A AU3440502A AU782080B2 AU 782080 B2 AU782080 B2 AU 782080B2 AU 34405/02 A AU34405/02 A AU 34405/02A AU 3440502 A AU3440502 A AU 3440502A AU 782080 B2 AU782080 B2 AU 782080B2
Authority
AU
Australia
Prior art keywords
formula
compound
benzothiadiazine
pyrrolo
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU34405/02A
Other languages
English (en)
Other versions
AU3440502A (en
Inventor
Christopher James Cobley
Elsa Foucher
Jean-Pierre Lecouve
James Andrew Ramsden
Gilles Thominot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of AU3440502A publication Critical patent/AU3440502A/en
Application granted granted Critical
Publication of AU782080B2 publication Critical patent/AU782080B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU34405/02A 2001-04-18 2002-04-18 New process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H- pyrrolo(2,1-c)(1,2,4)benzothiadiazine Ceased AU782080B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0105226 2001-04-18
FR0105226A FR2823753B1 (fr) 2001-04-18 2001-04-18 Nouveau procede de synthese de la (3as)-5,5-dioxo-2,3,3a, 4-tetrahydro-1h-pyrrolo [2,1-c] [1,2,4] benzothiadiazine

Publications (2)

Publication Number Publication Date
AU3440502A AU3440502A (en) 2002-10-24
AU782080B2 true AU782080B2 (en) 2005-06-30

Family

ID=8862416

Family Applications (1)

Application Number Title Priority Date Filing Date
AU34405/02A Ceased AU782080B2 (en) 2001-04-18 2002-04-18 New process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H- pyrrolo(2,1-c)(1,2,4)benzothiadiazine

Country Status (23)

Country Link
US (1) US6518422B2 (show.php)
EP (1) EP1251132B1 (show.php)
JP (1) JP4011956B2 (show.php)
KR (1) KR100468066B1 (show.php)
CN (1) CN1169811C (show.php)
AR (1) AR036871A1 (show.php)
AT (1) ATE269339T1 (show.php)
AU (1) AU782080B2 (show.php)
BR (1) BR0201307A (show.php)
CA (1) CA2382405C (show.php)
DE (1) DE60200627T2 (show.php)
DK (1) DK1251132T3 (show.php)
EA (1) EA004927B1 (show.php)
ES (1) ES2223031T3 (show.php)
FR (1) FR2823753B1 (show.php)
HU (1) HUP0201256A3 (show.php)
MX (1) MXPA02003639A (show.php)
NO (1) NO20021768L (show.php)
NZ (1) NZ518422A (show.php)
PL (1) PL353512A1 (show.php)
PT (1) PT1251132E (show.php)
SI (1) SI1251132T1 (show.php)
ZA (1) ZA200203085B (show.php)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2856065B1 (fr) * 2003-06-13 2005-08-19 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US20060014887A1 (en) * 2004-07-19 2006-01-19 3M Innovative Properties Company Method of hydrolyzing a dispersion of ionic fluoropolymer
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK2230094T3 (en) 2009-03-20 2014-03-03 Kremstal Tuerenwerk Gmbh Process for coating of panels

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0692484A1 (fr) * 1994-07-12 1996-01-17 Adir Et Compagnie Nouveau dérivé de benzothiadiazine, son procédé de préparation et les compositions pharmaceutiques qui le contiennent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294791A (en) * 1966-03-14 1966-12-27 American Home Prod Tetrahydro-2, 5-methano-1, 2, 5-benzothiadiazepine 1, 1-dioxide
US3471483A (en) * 1967-11-09 1969-10-07 American Home Prod 1 - substituted - 2,3,3a - 4 - tetrahydro - 1h-pyrrolo(2,1 - c)(1,2,4)benzothiadiazine,5,5-dioxide
JPH06192272A (ja) * 1992-12-24 1994-07-12 Japan Tobacco Inc 新規なトリアゾロベンゾチアジアジン及びトリアゾロベンゾチアジアゼピン誘導体
FR2812291B1 (fr) * 2000-07-28 2002-12-13 Adir Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0692484A1 (fr) * 1994-07-12 1996-01-17 Adir Et Compagnie Nouveau dérivé de benzothiadiazine, son procédé de préparation et les compositions pharmaceutiques qui le contiennent

Also Published As

Publication number Publication date
NO20021768L (no) 2002-10-21
ES2223031T3 (es) 2005-02-16
PL353512A1 (en) 2002-10-21
EA200200378A2 (ru) 2002-10-31
MXPA02003639A (es) 2004-11-12
EP1251132A1 (fr) 2002-10-23
EP1251132B1 (fr) 2004-06-16
AU3440502A (en) 2002-10-24
HUP0201256A2 (hu) 2002-12-28
CA2382405C (fr) 2007-03-06
AR036871A1 (es) 2004-10-13
CN1381455A (zh) 2002-11-27
EA004927B1 (ru) 2004-10-28
SI1251132T1 (en) 2004-10-31
DK1251132T3 (da) 2004-10-25
FR2823753B1 (fr) 2004-07-16
DE60200627D1 (de) 2004-07-22
HU0201256D0 (show.php) 2002-06-29
CN1169811C (zh) 2004-10-06
EA200200378A3 (ru) 2002-12-26
US20020161222A1 (en) 2002-10-31
KR20020081148A (ko) 2002-10-26
DE60200627T2 (de) 2005-07-14
FR2823753A1 (fr) 2002-10-25
NO20021768D0 (no) 2002-04-15
US6518422B2 (en) 2003-02-11
ZA200203085B (en) 2002-11-25
KR100468066B1 (ko) 2005-01-24
JP4011956B2 (ja) 2007-11-21
HUP0201256A3 (en) 2004-11-29
HK1049668A1 (en) 2003-05-23
BR0201307A (pt) 2003-06-10
JP2003012674A (ja) 2003-01-15
NZ518422A (en) 2002-12-20
PT1251132E (pt) 2004-09-30
CA2382405A1 (fr) 2002-10-18
ATE269339T1 (de) 2004-07-15

Similar Documents

Publication Publication Date Title
Sarkar et al. Microwave assisted synthesis of 3-benzazepin-2-ones as building blocks for 2, 3-disubstituted tetrahydro-3-benzazepines
Zhang et al. Access to 2′, 3′-dihydro-1′ H-spiro [indoline-3, 4′-pyridin]-2-ones via amino acid derived phosphine-catalyzed asymmetric [4+ 2] annulation with easily available oxindole-derived α, β-unsaturated imines
WO2000053608A1 (fr) Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
Kawashima et al. Asymmetric synthesis of (1 R, 2 S)-1-amino-2-vinylcyclopropanecarboxylic acid by sequential SN 2–SN 2′ dialkylation of (R)-N-(benzyl) proline-derived glycine Schiff base Ni (ii) complex
EP2800569B1 (en) Allosteric modulators of cb1 cannabinoid receptors
US20240067652A1 (en) Method of preparing indolinobenzodiazepine derivatives
AU782080B2 (en) New process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H- pyrrolo(2,1-c)(1,2,4)benzothiadiazine
WO2008071951A2 (en) Catalytic process for asymmetric hydrogenation
JP7669388B2 (ja) ４，５－ジヒドロ－１ｈ－ピラゾール及び中間体を製造する方法
WO2020121321A1 (en) Highly efficient process for the preparation of sitagliptin via rhodium catalyzed asymmetric hydrogenation
Feng et al. Asymmetric synthesis of the ring A substructure of genkwadane A
Marchalín et al. Synthesis of novel chiral 1, 4-dihydropyridinyl Schiff-base ligands, with characterization and evaluation of calcium channel blocker activity
CZ303113B6 (cs) Zpusob prípravy sitagliptinu
CN113943240A (zh) 一种布瓦西坦的新制备方法
HK1049668B (en) New process for the synthesis of (3as)-5,5-dioxo-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,2,4]benzothiadiazine
DE69505781T2 (de) 8-Oxo-5,8-dihydro-6H-dibenzo[a,g]chinolizin-13-propansäure-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren
Ruff et al. A combined vinylogous Mannich/Diels–Alder approach for the stereoselective synthesis of highly functionalized hexahydroindoles
JP2002255933A (ja) 光学活性７−アミノ−５−アザスピロ［２．４］ヘプタンの製造法
JP2006008518A (ja) 光学活性３−アミノ−１−ｔｅｒｔ−ブトキシカルボニルピロリジンの製造法
Piergentili et al. Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N, N, N-trimethyl (6-methyl-1, 4-dioxan-2-yl) methanaminium iodide
CN107445879B (zh) 拉曲替尼中间体的制备方法
Martín-Martínez et al. Bicyclic lactams as templates for peptidomimetics. Studies on stereoselective synthetic routes to 6-oxoperhydropyrrolo [1, 2-a] pyrazines
Sayago et al. Towards the stereoselective synthesis of α-methylated (2S, 3aS, 7aS)-octahydroindole-2-carboxylic acid
CN105418611B (zh) 一种四氢苯并吡咯并吡嗪并异喹啉衍生物的制备方法
JP2004099609A (ja) 光学活性７−アミノ−５−アザスピロ［２．４］ヘプタンの製造法