AU774628B2 - Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists - Google Patents

Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists Download PDF

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Publication number
AU774628B2
AU774628B2 AU52729/99A AU5272999A AU774628B2 AU 774628 B2 AU774628 B2 AU 774628B2 AU 52729/99 A AU52729/99 A AU 52729/99A AU 5272999 A AU5272999 A AU 5272999A AU 774628 B2 AU774628 B2 AU 774628B2
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AU
Australia
Prior art keywords
mcd
malonyl coa
activity
protein
citrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU52729/99A
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English (en)
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AU5272999A (en
Inventor
Jason Dyck
Gary D. Lopaschuk
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University of Alberta
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University of Alberta
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Publication date
Application filed by University of Alberta filed Critical University of Alberta
Publication of AU5272999A publication Critical patent/AU5272999A/en
Application granted granted Critical
Publication of AU774628B2 publication Critical patent/AU774628B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU52729/99A 1998-08-11 1999-08-09 Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists Ceased AU774628B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9609398P 1998-08-11 1998-08-11
US60/096093 1998-08-11
US25120099A 1999-02-16 1999-02-16
US09/251200 1999-02-16
PCT/CA1999/000734 WO2000009710A2 (en) 1998-08-11 1999-08-09 Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists

Publications (2)

Publication Number Publication Date
AU5272999A AU5272999A (en) 2000-03-06
AU774628B2 true AU774628B2 (en) 2004-07-01

Family

ID=26791076

Family Applications (1)

Application Number Title Priority Date Filing Date
AU52729/99A Ceased AU774628B2 (en) 1998-08-11 1999-08-09 Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists

Country Status (6)

Country Link
EP (1) EP1127139A2 (ko)
JP (1) JP2002522082A (ko)
KR (1) KR20010085373A (ko)
AU (1) AU774628B2 (ko)
CA (1) CA2339088A1 (ko)
WO (1) WO2000009710A2 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4155351B2 (ja) * 2001-02-20 2008-09-24 中外製薬株式会社 代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤としてのアゾール
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
BR0311161A (pt) * 2002-05-21 2005-03-29 Cv Therapeutics Inc Método de tratamento de diabetes
EP2208495B1 (en) 2003-08-01 2011-12-14 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors
US7696365B2 (en) 2003-08-01 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors
ATE400272T1 (de) 2003-08-01 2008-07-15 Chugai Pharmaceutical Co Ltd Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer
DE602004009582T2 (de) 2003-08-01 2009-01-02 Chugai Seiyaku K.K. Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer
WO2008106630A1 (en) * 2007-03-01 2008-09-04 Bristol-Myers Squibb Company Coupled enzyme assay for measuring acetyl coa carboxylase and malonyl coa decarboxylase activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
METHODS IN ENZYMOLOGY,1981,VOL.71, KOLATTUKUDY ET AL.,150-63 *

Also Published As

Publication number Publication date
KR20010085373A (ko) 2001-09-07
CA2339088A1 (en) 2000-02-24
AU5272999A (en) 2000-03-06
WO2000009710A2 (en) 2000-02-24
EP1127139A2 (en) 2001-08-29
WO2000009710A3 (en) 2001-06-07
JP2002522082A (ja) 2002-07-23

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