AU760889B2 - 1,2-disubstituted cyclopropanes - Google Patents

1,2-disubstituted cyclopropanes Download PDF

Info

Publication number
AU760889B2
AU760889B2 AU64279/99A AU6427999A AU760889B2 AU 760889 B2 AU760889 B2 AU 760889B2 AU 64279/99 A AU64279/99 A AU 64279/99A AU 6427999 A AU6427999 A AU 6427999A AU 760889 B2 AU760889 B2 AU 760889B2
Authority
AU
Australia
Prior art keywords
alkyl
compound
formula
hydrogen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU64279/99A
Other languages
English (en)
Other versions
AU6427999A (en
Inventor
Judith Hope Cohen
Donald Ward Combs
Philip James Rybczynski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of AU6427999A publication Critical patent/AU6427999A/en
Application granted granted Critical
Publication of AU760889B2 publication Critical patent/AU760889B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AU64279/99A 1998-10-14 1999-10-13 1,2-disubstituted cyclopropanes Ceased AU760889B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10413298P 1998-10-14 1998-10-14
US60/104132 1998-10-14
PCT/US1999/023779 WO2000021910A2 (en) 1998-10-14 1999-10-13 1,2-disubstituted cyclopropanes

Publications (2)

Publication Number Publication Date
AU6427999A AU6427999A (en) 2000-05-01
AU760889B2 true AU760889B2 (en) 2003-05-22

Family

ID=22298823

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64279/99A Ceased AU760889B2 (en) 1998-10-14 1999-10-13 1,2-disubstituted cyclopropanes

Country Status (5)

Country Link
US (1) US6172091B1 (enExample)
JP (1) JP2002527414A (enExample)
AU (1) AU760889B2 (enExample)
CA (1) CA2347092A1 (enExample)
WO (1) WO2000021910A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809396B1 (fr) * 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
US7176322B2 (en) 2002-05-23 2007-02-13 Amgen Inc. Calcium receptor modulating agents
US6908935B2 (en) 2002-05-23 2005-06-21 Amgen Inc. Calcium receptor modulating agents
AR045637A1 (es) 2003-09-12 2005-11-02 Amgen Inc Formulacion de disolucion rapida de un compuesto activo frente a los receptores de calcio
WO2005065050A2 (ja) 2003-12-25 2005-07-21 Asahi Kasei Pharma Corporation ２環化合物
JP4629036B2 (ja) 2004-05-28 2011-02-09 田辺三菱製薬株式会社 アリールアルキルアミン化合物及びその製法
EA200701745A1 (ru) 2005-03-17 2008-06-30 Пфайзер, Инк. Циклопропанкарбоксамидные производные
CA2601669A1 (en) * 2005-03-17 2006-09-28 Amgen Inc. Methods of decreasing calcification
MX2008012061A (es) * 2006-03-23 2008-12-17 Amgen Inc Metodos y composiciones para elaborar y utilizar polimorfos de cinacalcet.
WO2007124465A2 (en) * 2006-04-20 2007-11-01 Amgen Inc. Stable emulsion formulations
EP2021747B1 (en) * 2006-04-26 2018-08-01 Halliburton Energy Services, Inc. Fiber optic mems seismic sensor with mass supported by hinged beams
CA2681582C (en) 2007-03-30 2015-07-14 Amgen Inc. Methods of treating bowel disorders
WO2010104882A1 (en) 2009-03-10 2010-09-16 Amgen Inc. Methods of modulating sperm motility
JP2012528084A (ja) 2009-05-27 2012-11-12 レオ ファーマ アクティーゼルスカブ 新規のカルシウム感知受容体調節化合物およびその医薬用途
WO2010136037A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
US8497271B2 (en) * 2009-10-07 2013-07-30 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
EP2588445A1 (en) 2010-06-30 2013-05-08 Leo Pharma A/S New polymorphic form of a calcimimetic compound
US8946474B2 (en) 2010-06-30 2015-02-03 Leo Pharma A/S Polymorphic form of a calcimimetic compound
WO2012069421A1 (en) 2010-11-26 2012-05-31 Leo Pharma A/S Calcium-sensing receptor-active compounds
RU2013128981A (ru) 2010-11-26 2015-01-10 Лео Фарма А/С Соединения, активные в отношении чувствительных к кальцию рецепторов
WO2012069402A1 (en) 2010-11-26 2012-05-31 Leo Pharma A/S Substituted cyclopentyl - azines as casr- active compounds
CN103270018A (zh) 2010-11-26 2013-08-28 利奥制药有限公司 钙敏感受体激活化合物
EP2928860A1 (en) * 2012-12-10 2015-10-14 H. Lundbeck A/S New positive allosteric modulators of nicotinic acetylcholine receptor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3802981A1 (de) 1988-02-02 1989-08-10 Basf Ag Verfahren zur reduktion reduzierbarer verbindungen
FR2636625B1 (fr) 1988-09-01 1990-11-09 Jouveinal Sa Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese
US5169780A (en) 1989-06-22 1992-12-08 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
DE69233586T2 (de) 1991-08-23 2006-09-28 NPS Pharmaceuticals, Inc., Salt Lake City Kalzium-Rezeptor aktive Verbindungen
US6071970A (en) 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
AU3777093A (en) 1993-02-23 1994-09-14 Brigham And Women's Hospital Calcium receptor-active molecules
AU710575B2 (en) 1994-02-08 1999-09-23 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US5504253A (en) 1994-07-15 1996-04-02 Nps Pharmaceuticals, Inc. Amine preparation
AU3414295A (en) 1994-08-19 1996-03-14 Nps Pharmaceuticals, Inc. Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases
EP1275635A1 (en) 1994-10-21 2003-01-15 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US5753709A (en) * 1995-06-07 1998-05-19 Bristol-Myers Squibb Company N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
CA2176854A1 (en) 1995-06-07 1996-12-08 Daniel J. Keavy N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics

Also Published As

Publication number Publication date
US6172091B1 (en) 2001-01-09
WO2000021910A3 (en) 2000-07-06
CA2347092A1 (en) 2000-04-20
WO2000021910A2 (en) 2000-04-20
JP2002527414A (ja) 2002-08-27
AU6427999A (en) 2000-05-01

Similar Documents

Publication Publication Date Title
US6172091B1 (en) 1,2-Disubstituted cyclopropanes
KR0179661B1 (ko) N-페닐알킬 치환된 알파-아미노 카복스아미드 유도체 및 이를 포함하는 약제학적 조성물 및 이의 제조방법
JP5582634B2 (ja) ４−置換フェノキシフェニル酢酸誘導体
US6974810B2 (en) 4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity
IE903957A1 (en) Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
JP2004505070A (ja) カルボキサミド化合物およびそれらのヒト１１ｃｂｙ受容体アンタゴニストとしての使用
KR100412747B1 (ko) 2-(4-치환된)-벤질아미노-2-메틸-프로판아미드유도체,이의제조방법및이를포함하는약제학적조성물
WO2008035381A2 (en) Process for the preparation of amine derivatives as calcimimetics
FR2740134A1 (fr) Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant
CA2200083A1 (en) Neurokinin antagonists
KR20040093123A (ko) Ｎｋ1 길항제
FR2880023A1 (fr) Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
SK277973B6 (en) 1,2 - etanediole derivatives and their salts, and method of their production
CA2663080A1 (fr) Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique.
GB2142021A (en) 1 4-dihydropyridine derivatives their preparation and pharmaceutical compositions containing them
CA2849960A1 (en) Aryl or n-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands
CA2429267C (fr) Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
MXPA01003846A (en) 1,2-disubstituted cyclopropanes
TW201326125A (zh) 以被胺基取代之甲基磺醯胺衍生物做為類香草素受體之配位體
JPH0825998B2 (ja) ２−アミノアセトアミドピリジニル誘導体
SK286980B6 (sk) Substituované deriváty propán-1,3-diamínu, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie
CZ148595A3 (en) Novel phenylethyl amines and phenylpropyl amines, process of their preparation and pharmaceutical composition containing thereof
KR101344765B1 (ko) 4,5-디히드로옥사졸-2-일벤젠 유도체의 제조방법
FR2676448A1 (fr) Nouveaux derives amidiques de 1-amino octahydropyrido [2,1-c] [1,4] oxazine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2941953A1 (fr) Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)