AU749597C - Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use - Google Patents

Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use

Info

Publication number
AU749597C
AU749597C AU20104/99A AU2010499A AU749597C AU 749597 C AU749597 C AU 749597C AU 20104/99 A AU20104/99 A AU 20104/99A AU 2010499 A AU2010499 A AU 2010499A AU 749597 C AU749597 C AU 749597C
Authority
AU
Australia
Prior art keywords
alkyl
hydrogen
group
compound
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU20104/99A
Other languages
English (en)
Other versions
AU749597B2 (en
AU2010499A (en
Inventor
Wan-Ru Chao
Ling Jong
Richard H. Peters
Masato Tanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of AU2010499A publication Critical patent/AU2010499A/en
Publication of AU749597B2 publication Critical patent/AU749597B2/en
Application granted granted Critical
Publication of AU749597C publication Critical patent/AU749597C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AU20104/99A 1997-12-24 1998-12-23 Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Ceased AU749597C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/998877 1997-12-24
US08/998,877 US6054446A (en) 1997-12-24 1997-12-24 Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
PCT/US1998/027406 WO1999033859A2 (en) 1997-12-24 1998-12-23 Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use

Publications (3)

Publication Number Publication Date
AU2010499A AU2010499A (en) 1999-07-19
AU749597B2 AU749597B2 (en) 2002-06-27
AU749597C true AU749597C (en) 2003-02-20

Family

ID=25545637

Family Applications (1)

Application Number Title Priority Date Filing Date
AU20104/99A Ceased AU749597C (en) 1997-12-24 1998-12-23 Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use

Country Status (14)

Country Link
US (3) US6054446A (enExample)
EP (4) EP1056768B1 (enExample)
JP (4) JP2001525855A (enExample)
KR (1) KR100464739B1 (enExample)
CN (2) CN101130567B (enExample)
AU (1) AU749597C (enExample)
BR (1) BR9814435A (enExample)
CA (1) CA2281844C (enExample)
DE (2) DE69839893D1 (enExample)
HU (1) HUP0100136A3 (enExample)
IL (1) IL136972A0 (enExample)
NO (1) NO317978B1 (enExample)
RU (1) RU2233288C2 (enExample)
WO (1) WO1999033859A2 (enExample)

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BR9814435A (pt) 2004-08-10
RU2233288C2 (ru) 2004-07-27
US20020032181A1 (en) 2002-03-14
JP4959276B2 (ja) 2012-06-20
NO20003254D0 (no) 2000-06-22
DE69839893D1 (de) 2008-09-25
JP2001525855A (ja) 2001-12-11
JP4718512B2 (ja) 2011-07-06
HUP0100136A3 (en) 2002-04-29
CA2281844C (en) 2007-06-19
EP1056768B1 (en) 2003-03-19
KR100464739B1 (ko) 2005-01-05
AU749597B2 (en) 2002-06-27
KR20000075580A (ko) 2000-12-15
WO1999033859A2 (en) 1999-07-08
IL136972A0 (en) 2001-06-14
DE69812433T2 (de) 2004-02-12
WO1999033859A3 (en) 1999-12-23
JP2007051148A (ja) 2007-03-01
EP1847548A2 (en) 2007-10-24
CN101130567B (zh) 2011-11-23
CN101130567A (zh) 2008-02-27
AU2010499A (en) 1999-07-19
EP1310509B1 (en) 2008-08-13
JP2007031446A (ja) 2007-02-08
JP3968114B2 (ja) 2007-08-29
JP2007269797A (ja) 2007-10-18
EP1310509A2 (en) 2003-05-14
CN1291196A (zh) 2001-04-11
HUP0100136A2 (hu) 2001-08-28
US6455517B1 (en) 2002-09-24
NO20003254L (no) 2000-08-21
CN1332974C (zh) 2007-08-22
WO1999033859A9 (en) 1999-09-23
EP1847548A3 (en) 2012-09-12
CA2281844A1 (en) 1999-07-08
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NO317978B1 (no) 2005-01-17
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US6054446A (en) 2000-04-25
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DE69812433D1 (de) 2003-04-24
EP1310509A3 (en) 2004-12-08

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