AU748887B2 - Beta-sheet mimetics and methods relating to the use thereof - Google Patents

Beta-sheet mimetics and methods relating to the use thereof Download PDF

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Publication number
AU748887B2
AU748887B2 AU66557/98A AU6655798A AU748887B2 AU 748887 B2 AU748887 B2 AU 748887B2 AU 66557/98 A AU66557/98 A AU 66557/98A AU 6655798 A AU6655798 A AU 6655798A AU 748887 B2 AU748887 B2 AU 748887B2
Authority
AU
Australia
Prior art keywords
mmol
pct
solution
synthesis
stirred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66557/98A
Other languages
English (en)
Other versions
AU6655798A (en
Inventor
Michael S. Kahn
Jessymol Mathew
Michael K. Mcmillian
Maher N. Qaber
John E. Tulinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myriad Genetics Inc
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Publication of AU6655798A publication Critical patent/AU6655798A/en
Application granted granted Critical
Publication of AU748887B2 publication Critical patent/AU748887B2/en
Assigned to MYRIAD GENETICS, INC. reassignment MYRIAD GENETICS, INC. Alteration of Name(s) in Register under S187 Assignors: MOLECUMETICS, LTD.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
AU66557/98A 1998-02-12 1998-02-12 Beta-sheet mimetics and methods relating to the use thereof Ceased AU748887B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/002891 WO1999041276A1 (en) 1998-02-12 1998-02-12 β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF

Publications (2)

Publication Number Publication Date
AU6655798A AU6655798A (en) 1999-08-30
AU748887B2 true AU748887B2 (en) 2002-06-13

Family

ID=22266392

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66557/98A Ceased AU748887B2 (en) 1998-02-12 1998-02-12 Beta-sheet mimetics and methods relating to the use thereof

Country Status (9)

Country Link
EP (1) EP1053246B1 (cg-RX-API-DMAC7.html)
JP (1) JP2002503674A (cg-RX-API-DMAC7.html)
KR (1) KR20010040939A (cg-RX-API-DMAC7.html)
AT (1) ATE230414T1 (cg-RX-API-DMAC7.html)
AU (1) AU748887B2 (cg-RX-API-DMAC7.html)
CA (1) CA2319766A1 (cg-RX-API-DMAC7.html)
DE (1) DE69810513T2 (cg-RX-API-DMAC7.html)
ES (1) ES2192764T3 (cg-RX-API-DMAC7.html)
WO (1) WO1999041276A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003525294A (ja) * 2000-02-29 2003-08-26 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Ｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害剤
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US20060276497A1 (en) 2000-05-09 2006-12-07 Cephalon, Inc. Novel multicyclic compounds and the use thereof
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
CN1642550A (zh) * 2002-02-14 2005-07-20 美瑞德生物工程公司 β－折叠模拟物和组合物及其有关方法
JP2011525927A (ja) * 2008-06-25 2011-09-29 シェーリング コーポレイション 複素環式抗菌剤の合成および使用
BR112017006920A8 (pt) 2014-10-06 2023-03-07 Quince Therapeutics Inc Inibidores de lisina gingipaína
EP3374352A4 (en) 2015-11-09 2019-10-02 Cortexyme, Inc. GINGIPAINE ARGININE INHIBITORS
PL3486242T3 (pl) 2016-08-31 2022-03-21 Jiangsu Hengrui Medicine Co. Ltd. Pochodna oksopikolinamidu, sposób jej wytwarzania i zastosowanie farmaceutyczne
MX2019003087A (es) 2016-09-16 2019-08-12 Cortexyme Inc Inhibidores cetónicos de gingipain de lisina.
EP3822264A4 (en) 2018-07-02 2021-11-10 Jiangsu Hengrui Medicine Co., Ltd. CRYSTALLINE FORMS OF AN OXYPYRIDINE AMIDE DERIVATIVE AND THEIR PREPARATION PROCESS
WO2021057818A1 (zh) 2019-09-27 2021-04-01 深圳信立泰药业股份有限公司 FXIa抑制剂及其制备方法和医药用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2117123T3 (es) * 1992-02-14 1998-08-01 Merrell Pharma Inc Derivados de aminocetilmercaptoacetilamida utilizados como inhibidores de la encefalinasa y del enzima de conversion de angiotensina.
ES2138622T3 (es) * 1992-05-15 2000-01-16 Merrell Pharma Inc Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca.
EP0618223A3 (en) * 1993-03-08 1996-06-12 Sandoz Ltd Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents.
SK83897A3 (en) * 1994-12-22 1998-05-06 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
EP0815123B1 (en) * 1995-03-24 2001-10-04 Molecumetics, Ltd. Beta-sheet mimetics and use thereof as protease inhibitors
WO1996030396A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
IT1277405B1 (it) * 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina
WO1998005333A1 (en) * 1996-08-05 1998-02-12 Molecumetics Ltd. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors

Also Published As

Publication number Publication date
EP1053246A1 (en) 2000-11-22
DE69810513T2 (de) 2004-03-18
AU6655798A (en) 1999-08-30
JP2002503674A (ja) 2002-02-05
CA2319766A1 (en) 1999-08-19
ATE230414T1 (de) 2003-01-15
KR20010040939A (ko) 2001-05-15
EP1053246B1 (en) 2003-01-02
DE69810513D1 (de) 2003-02-06
WO1999041276A1 (en) 1999-08-19
ES2192764T3 (es) 2003-10-16

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: MYRIAD GENETICS, INC.

Free format text: FORMER OWNER WAS: MOLECUMETICS LTD.