AU747702B2 - Compounds containing six-membered rings, processes for their preparation, and their use as medicaments - Google Patents

Compounds containing six-membered rings, processes for their preparation, and their use as medicaments Download PDF

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Publication number
AU747702B2
AU747702B2 AU95694/98A AU9569498A AU747702B2 AU 747702 B2 AU747702 B2 AU 747702B2 AU 95694/98 A AU95694/98 A AU 95694/98A AU 9569498 A AU9569498 A AU 9569498A AU 747702 B2 AU747702 B2 AU 747702B2
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AU
Australia
Prior art keywords
group
groups
typically
acid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU95694/98A
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English (en)
Other versions
AU9569498A (en
Inventor
Norbert W Bischofberger
Terrence C. Dahl
Michael J.M. Hitchcock
Choung U. Kim
Willard Lew
Hongtao Liu
Roger G. Mills
Matthew A. Williams
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Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AU9569498A publication Critical patent/AU9569498A/en
Application granted granted Critical
Publication of AU747702B2 publication Critical patent/AU747702B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AU95694/98A 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments Expired AU747702B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5930897P 1997-09-17 1997-09-17
US60/059308 1997-09-17
US93864497A 1997-09-26 1997-09-26
US6019597P 1997-09-26 1997-09-26
US60/060195 1997-09-26
US08/938644 1997-09-26
PCT/US1998/019355 WO1999014185A1 (fr) 1997-09-17 1998-09-15 Composes contenant des chaines fermees a six elements, procedes de preparation de ces composes, et leur utilisation comme medicaments

Publications (2)

Publication Number Publication Date
AU9569498A AU9569498A (en) 1999-04-05
AU747702B2 true AU747702B2 (en) 2002-05-16

Family

ID=27369627

Family Applications (1)

Application Number Title Priority Date Filing Date
AU95694/98A Expired AU747702B2 (en) 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments

Country Status (15)

Country Link
EP (1) EP1015417A1 (fr)
JP (1) JP2001516739A (fr)
KR (1) KR20010024123A (fr)
CN (1) CN1272105A (fr)
AR (1) AR013960A1 (fr)
AU (1) AU747702B2 (fr)
BR (1) BR9812649A (fr)
CA (1) CA2303323A1 (fr)
EA (1) EA003989B1 (fr)
ID (1) ID25516A (fr)
IL (1) IL134691A0 (fr)
IN (1) IN190983B (fr)
NZ (1) NZ502988A (fr)
TR (1) TR200000723T2 (fr)
WO (1) WO1999014185A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2200199A (en) * 1997-12-17 1999-07-19 Biocryst Pharmaceuticals, Inc. Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
EP1059283B1 (fr) 1999-06-11 2003-05-28 F. Hoffmann-La Roche Ag Procédé pour préparer un inhibiteur de la neuraminidase ro-64-0796
BR0010525A (pt) * 1999-10-19 2002-11-26 Abbott Lab cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6403824B2 (en) * 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
WO2001080892A1 (fr) * 2000-04-25 2001-11-01 Sankyo Company, Limited Substances preventives de la grippe
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
CA2633538A1 (fr) * 2005-12-28 2007-07-05 F. Hoffmann-La Roche Ag Intermediaire epoxy dans la synthese du tamiflu
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
KR20120115262A (ko) * 2009-11-11 2012-10-17 쓰리엠 이노베이티브 프로퍼티즈 캄파니 중합체 조성물 및 그의 제조 방법 및 물품
DE102011117128A1 (de) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
CN102659615B (zh) * 2012-05-09 2014-05-07 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
RU2520836C1 (ru) * 2013-02-27 2014-06-27 Александр Васильевич Иващенко (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения
RU2633085C2 (ru) * 2014-05-20 2017-10-11 Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" Противовирусное лекарственное средство в виде капсул и способ его получения
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法
CN108047076B (zh) * 2017-12-26 2020-05-08 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN110194728B (zh) * 2019-06-19 2021-04-30 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
CN114057599A (zh) * 2020-07-29 2022-02-18 广州市恒诺康医药科技有限公司 神经氨酸酶抑制剂类化合物、其药物组合物及其用途
CN116375595A (zh) * 2023-03-31 2023-07-04 重庆医药高等专科学校 一种磷酸奥司他韦的制备方法及精制方法
CN116666669B (zh) * 2023-07-25 2023-10-03 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
WO1992006691A1 (fr) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Composes anti-viraux qui lient le site actif de la neuraminidase de la grippe et presentent une activite in vivo contre l'orthomixovirus et le paramyxovirus
JP3300365B2 (ja) * 1995-02-27 2002-07-08 ギリアード サイエンシーズ，インコーポレイテッド ウイルスまたは細菌ノイラミニダーゼの新規な選択的インヒビター
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
PT920410E (pt) * 1996-08-23 2002-07-31 Gilead Sciences Inc Preparacao de derivados de carboxilato de ciclo-hexeno

Also Published As

Publication number Publication date
JP2001516739A (ja) 2001-10-02
CN1272105A (zh) 2000-11-01
EA003989B1 (ru) 2003-12-25
EA200000332A1 (ru) 2000-10-30
KR20010024123A (ko) 2001-03-26
CA2303323A1 (fr) 1999-03-25
BR9812649A (pt) 2000-08-22
IL134691A0 (en) 2001-04-30
IN190983B (fr) 2003-09-06
ID25516A (id) 2000-10-05
WO1999014185A1 (fr) 1999-03-25
AU9569498A (en) 1999-04-05
NZ502988A (en) 2002-08-28
TR200000723T2 (tr) 2001-06-21
EP1015417A1 (fr) 2000-07-05
AR013960A1 (es) 2001-01-31

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired