AU747663B2 - Arylsulfonanilide ureas - Google Patents

Arylsulfonanilide ureas Download PDF

Info

Publication number
AU747663B2
AU747663B2 AU60580/99A AU6058099A AU747663B2 AU 747663 B2 AU747663 B2 AU 747663B2 AU 60580/99 A AU60580/99 A AU 60580/99A AU 6058099 A AU6058099 A AU 6058099A AU 747663 B2 AU747663 B2 AU 747663B2
Authority
AU
Australia
Prior art keywords
group
alkyl
hydrogen
compound
heteroalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU60580/99A
Other languages
English (en)
Other versions
AU6058099A (en
Inventor
Jonathan B. Houze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tularik Inc
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Publication of AU6058099A publication Critical patent/AU6058099A/en
Application granted granted Critical
Publication of AU747663B2 publication Critical patent/AU747663B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
AU60580/99A 1998-09-23 1999-09-21 Arylsulfonanilide ureas Ceased AU747663B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10088898P 1998-09-23 1998-09-23
US60/100888 1998-09-23
PCT/US1999/022013 WO2000017159A1 (en) 1998-09-23 1999-09-21 Arylsulfonanilide ureas

Publications (2)

Publication Number Publication Date
AU6058099A AU6058099A (en) 2000-04-10
AU747663B2 true AU747663B2 (en) 2002-05-16

Family

ID=22282047

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60580/99A Ceased AU747663B2 (en) 1998-09-23 1999-09-21 Arylsulfonanilide ureas

Country Status (23)

Country Link
US (3) US6214880B1 (enExample)
EP (1) EP1115701B1 (enExample)
JP (1) JP3926983B2 (enExample)
KR (1) KR100642184B1 (enExample)
CN (1) CN100335461C (enExample)
AT (1) ATE240940T1 (enExample)
AU (1) AU747663B2 (enExample)
BR (1) BR9913903A (enExample)
CA (1) CA2343204C (enExample)
CZ (1) CZ2001934A3 (enExample)
DE (1) DE69908156T2 (enExample)
DK (1) DK1115701T3 (enExample)
EA (1) EA003924B1 (enExample)
ES (1) ES2194547T3 (enExample)
HU (1) HUP0103884A3 (enExample)
IL (2) IL142066A0 (enExample)
NO (1) NO20011453L (enExample)
NZ (1) NZ510435A (enExample)
PL (1) PL198394B1 (enExample)
PT (1) PT1115701E (enExample)
SK (1) SK284757B6 (enExample)
WO (1) WO2000017159A1 (enExample)
ZA (1) ZA200102033B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9508644D0 (en) * 1995-04-28 1995-06-14 Exxon Chemical Patents Inc Fuel compositions
HUP0103884A3 (en) * 1998-09-23 2002-11-28 Tularik Inc South San Francisc Arylsulfonanilide urea-derivatives, pharmaceutical compositions containing them and their use
US6316503B1 (en) * 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
CA2380078C (en) * 1999-07-29 2008-05-06 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides
CO5280089A1 (es) * 2000-03-16 2003-05-30 Smithkline Beecham Corp Antagonistas del receptor il-8
US6664259B2 (en) 2000-03-16 2003-12-16 Smithkline Beecham Corporation Il-8 receptor antagonists
UY26627A1 (es) * 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
US6777446B2 (en) 2000-09-05 2004-08-17 Tularik, Inc. FXR modulators
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
AU2002234165A1 (en) 2000-11-03 2002-05-27 Tularik, Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
WO2002067865A2 (en) 2001-02-28 2002-09-06 Temple University Of The Commonwealth System Of Higher Education N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof
AUPR738301A0 (en) * 2001-08-30 2001-09-20 Starpharma Limited Chemotherapeutic agents
EP1476423B1 (en) * 2002-01-30 2008-10-15 Amgen Inc. Arylsulfonamidobenzylic compounds
US7112606B2 (en) * 2002-01-30 2006-09-26 Amgen Inc. Heterocyclic arylsulfonamidobenzylic compounds
IL163608A0 (en) 2002-02-28 2005-12-18 Univ Temple Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
MY143477A (en) * 2002-10-29 2011-05-31 Smithkline Beecham Corp Il-8 receptor antagonists
MXPA06001566A (es) * 2003-08-12 2006-05-15 Amgen Inc Compuestos arilsulfonamidobencilicos.
US20050124664A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Urea thiadiazole inhibitors of plasminogen activator inhibior-1
US20050154455A1 (en) * 2003-12-18 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050261762A1 (en) * 2004-05-21 2005-11-24 Medtronic Vascular, Inc. Medical devices to prevent or inhibit restenosis
US20060062822A1 (en) * 2004-09-21 2006-03-23 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20070027530A1 (en) * 2005-07-26 2007-02-01 Medtronic Vascular, Inc. Intraluminal device, catheter assembly, and method of use thereof
FI20055498A0 (fi) * 2005-09-16 2005-09-16 Biotie Therapies Corp Sulfonamidijohdannaisia
US20070067020A1 (en) * 2005-09-22 2007-03-22 Medtronic Vasular, Inc. Intraluminal stent, delivery system, and a method of treating a vascular condition
WO2007124423A2 (en) * 2006-04-21 2007-11-01 Smithkline Beecham Corporation Il-8 receptor antagonists
UA98456C2 (en) * 2006-04-21 2012-05-25 Смитклайн Бичам Корпорейшн Il-8 receptor antagonists
WO2007139930A2 (en) * 2006-05-26 2007-12-06 Bayer Healthcare Llc Drug combinations with substituted diaryl ureas for the treatment of cancer
CL2007001829A1 (es) * 2006-06-23 2008-01-25 Smithkline Beecham Corp P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
CA2702992C (en) * 2007-10-19 2017-09-19 The Board Of Regents Of The University Of Texas System Methods of inhibiting bacterial virulence and compounds relating thereto
US20110275635A1 (en) * 2009-01-09 2011-11-10 The Uab Research Foundation Small molecule inhibitors of nads, namnat, and nmnat
US9444712B2 (en) 2012-11-21 2016-09-13 Cisco Technology, Inc. Bandwidth on-demand services in multiple layer networks
BR112015011253B1 (pt) 2012-11-21 2021-11-09 Nippon Soda Co., Ltd Material de gravação, folha de gravação, método para uso de um composto
EP3438091A4 (en) * 2016-03-30 2019-11-27 Ajinomoto Co., Inc. CONNECTION WITH INCREASING ACTIVITY FOR ACTION OF GLUCAGON LIKE PEPTIDE-1 RECEPTOR

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1955207A (en) 1931-09-16 1934-04-17 Ig Farbenindustrie Ag Mothproofing agent
DE622494C (de) 1932-01-03 1935-11-29 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Mono- bzw. Polynitropolysulfonen und deren Reduktionsprodukten
US2358365A (en) 1940-08-03 1944-09-19 Parke Davis & Co Sulphonamide derivatives and process for obtaining the same
US2402623A (en) 1943-06-24 1946-06-25 Rohm & Haas Nu-nitroaryl haloarylsulphonamides
CH362688A (de) 1957-09-10 1962-06-30 Geigy Ag J R Verfahren zur Herstellung von neuen Arylsulfonarylamiden
GB938890A (en) 1961-02-03 1963-10-09 Boots Pure Drug Co Ltd New fungicidal compositions and compounds
CH504416A (de) 1966-12-05 1971-03-15 Ciba Geigy Ag Verfahren zur Herstellung von aromatischen Sulfamoylverbindungen
GB1242057A (en) 1968-07-04 1971-08-11 Ici Ltd Derivatives of 4-hydroxytetrafluoropyridine and the use thereof as plant growth regulators
NL174644C (nl) 1970-04-13 1984-07-16 Minnesota Mining & Mfg Werkwijze ter bereiding van een herbicide verbinding; tevens werkwijze voor de bereiding van een preparaat met herbicide werking.
FR2456731A1 (fr) 1979-05-16 1980-12-12 Choay Sa Nouveaux derives substitues d'ary
DE3623184A1 (de) 1986-07-10 1988-01-14 Kali Chemie Ag Verfahren zur herstellung von n-fluorsulfonamiden
US4883914A (en) 1987-08-17 1989-11-28 American Cyanamid Company Benzenesulfonyl carboxamide compounds useful as herbicidal agents
DE3804990A1 (de) 1988-02-18 1989-08-31 Basf Ag Herbizid wirksame, heterocyclisch substituierte sulfonamide
DE3905075A1 (de) 1989-02-18 1990-08-30 Hoechst Ag Benzolsulfonamide und verfahren zu ihrer herstellung
FR2645537B1 (fr) 1989-04-05 1994-03-04 Fabre Medicament Pierre Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique
FR2665440B1 (fr) 1990-07-31 1994-02-04 Lipha Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant.
US5189211A (en) 1990-08-01 1993-02-23 Taisho Pharmaceutical Co., Ltd. Sulfonamide derivatives
EP0472053B1 (en) * 1990-08-20 1998-06-17 Eisai Co., Ltd. Sulfonamide derivatives
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
ATE249213T1 (de) * 1996-02-22 2003-09-15 Tularik Inc Pentafluorobenzensulfonamiden und analoge
US6482860B1 (en) * 1996-07-19 2002-11-19 Tularik Inc. Pentafluorobenzenesulfonamides and analogs
EP1030844A1 (en) 1997-11-10 2000-08-30 Array Biopharma Inc. Compounds which inhibit tryptase activity
WO1999032433A1 (en) 1997-12-23 1999-07-01 Warner-Lambert Company Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
HUP0103884A3 (en) * 1998-09-23 2002-11-28 Tularik Inc South San Francisc Arylsulfonanilide urea-derivatives, pharmaceutical compositions containing them and their use
CA2380078C (en) * 1999-07-29 2008-05-06 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides

Also Published As

Publication number Publication date
ZA200102033B (en) 2001-09-12
DE69908156D1 (de) 2003-06-26
US6583165B2 (en) 2003-06-24
AU6058099A (en) 2000-04-10
NO20011453D0 (no) 2001-03-22
US20030207864A1 (en) 2003-11-06
US7060718B2 (en) 2006-06-13
WO2000017159A1 (en) 2000-03-30
PL198394B1 (pl) 2008-06-30
EA200100376A1 (ru) 2001-08-27
KR20010079892A (ko) 2001-08-22
JP3926983B2 (ja) 2007-06-06
CA2343204C (en) 2008-04-29
EP1115701B1 (en) 2003-05-21
EP1115701A1 (en) 2001-07-18
ATE240940T1 (de) 2003-06-15
DK1115701T3 (da) 2003-06-23
US6214880B1 (en) 2001-04-10
NO20011453L (no) 2001-05-23
EA003924B1 (ru) 2003-10-30
DE69908156T2 (de) 2003-12-24
BR9913903A (pt) 2001-07-03
NZ510435A (en) 2003-04-29
HK1038913A1 (en) 2002-04-04
CA2343204A1 (en) 2000-03-30
HUP0103884A3 (en) 2002-11-28
HUP0103884A2 (hu) 2002-05-29
CN1319088A (zh) 2001-10-24
PL346797A1 (en) 2002-02-25
ES2194547T3 (es) 2003-11-16
IL142066A0 (en) 2002-03-10
JP2002526472A (ja) 2002-08-20
CN100335461C (zh) 2007-09-05
US20010027211A1 (en) 2001-10-04
SK284757B6 (sk) 2005-11-03
IL142066A (en) 2006-07-05
SK4002001A3 (en) 2001-09-11
PT1115701E (pt) 2003-09-30
CZ2001934A3 (cs) 2001-08-15
KR100642184B1 (ko) 2006-11-10

Similar Documents

Publication Publication Date Title
AU747663B2 (en) Arylsulfonanilide ureas
EP1246795B1 (en) Antibacterial agents
DE69129611T2 (de) Sulfonamid-Derivate
DE69418243T2 (de) N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung
NZ506417A (en) Anti-viral pyrimidine derivatives
HU184943B (en) Process for producing sulfonyl-urea compounds and pharmaceutical compositions containing them
JP2011500734A (ja) 新規なヒストンデアセチラーゼインヒビター、その調製方法および使用
RU2434855C2 (ru) Новые производные имидазола, их получение и использование в качестве лекарственных средств
JP3101677B2 (ja) ジフェニルピペラジン誘導体及びこれを含有する循環器用薬
RU2195452C2 (ru) Цианогуанидины, способы их получения и фармацевтический препарат на их основе
WO2004058713A1 (en) Differential tumor cytotoxocity compounds and compositions
US9278937B2 (en) Substituted 2-imidazolidinones and 2-imidazolones and their use in the treatment of cancer
EP1285911A2 (en) Arylsulfonanilide ureas
SK12812003A3 (sk) Derivát bicyklického quanidínu, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
HK1038913B (en) Arylsulfonanilide ureas
MXPA01002717A (es) Ureas de arilsulfonanilida
SK285130B6 (sk) Farmaceutický prostriedok obsahujúci derivát [(aminoiminometyl)amino]alkánkarboxamidu, tento derivát a spôsob jeho prípravy a použitie tohto derivátua prostriedku
Patel et al. Synthesis and antibacterial activity of thioureido amide of fluoroquinolone
WO2006037468A1 (en) Hiv reverse transcriptase inhibitors

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)