AU744338B2 - 1,3,8-triazaspiro(4.5)decan-4-one derivatives - Google Patents
1,3,8-triazaspiro(4.5)decan-4-one derivatives Download PDFInfo
- Publication number
- AU744338B2 AU744338B2 AU96087/98A AU9608798A AU744338B2 AU 744338 B2 AU744338 B2 AU 744338B2 AU 96087/98 A AU96087/98 A AU 96087/98A AU 9608798 A AU9608798 A AU 9608798A AU 744338 B2 AU744338 B2 AU 744338B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- phenyl
- formula
- decan
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000008631 1,3,8-triazaspiro[4.5]decan-4-ones Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 210
- 239000000203 mixture Substances 0.000 claims description 89
- 239000001257 hydrogen Substances 0.000 claims description 40
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- MKJDUHZPLQYUCB-UHFFFAOYSA-N decan-4-one Chemical compound CCCCCCC(=O)CCC MKJDUHZPLQYUCB-UHFFFAOYSA-N 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- -1 cyanomethyl Chemical group 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
- PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 108090000622 Nociceptin Proteins 0.000 claims description 19
- 150000002431 hydrogen Chemical group 0.000 claims description 18
- HTQWGIHCFPWKAS-UHFFFAOYSA-N 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1CNCCC11C(=O)NCN1C1=CC=CC=C1 HTQWGIHCFPWKAS-UHFFFAOYSA-N 0.000 claims description 16
- 208000002193 Pain Diseases 0.000 claims description 16
- 208000035475 disorder Diseases 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 12
- 208000030159 metabolic disease Diseases 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 208000024891 symptom Diseases 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 9
- GWNDTWSMNIBSRN-UHFFFAOYSA-N 8-cyclodecyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1CN(C2CCCCCCCCC2)CCC11C(=O)NCN1C1=CC=CC=C1 GWNDTWSMNIBSRN-UHFFFAOYSA-N 0.000 claims description 8
- 208000027796 Blood pressure disease Diseases 0.000 claims description 8
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- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 8
- 230000001154 acute effect Effects 0.000 claims description 8
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- 230000004872 arterial blood pressure Effects 0.000 claims description 8
- 230000029142 excretion Effects 0.000 claims description 8
- 230000000926 neurological effect Effects 0.000 claims description 8
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 238000011321 prophylaxis Methods 0.000 claims description 7
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 6
- 125000002648 azanetriyl group Chemical group *N(*)* 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N acetonitrile Substances CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 230000036506 anxiety Effects 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
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- 230000002152 alkylating effect Effects 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
- 230000006735 deficit Effects 0.000 claims description 4
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
- LLBZPESJRQGYMB-UHFFFAOYSA-N 4-one Natural products O1C(C(=O)CC)CC(C)C11C2(C)CCC(C3(C)C(C(C)(CO)C(OC4C(C(O)C(O)C(COC5C(C(O)C(O)CO5)OC5C(C(OC6C(C(O)C(O)C(CO)O6)O)C(O)C(CO)O5)OC5C(C(O)C(O)C(C)O5)O)O4)O)CC3)CC3)=C3C2(C)CC1 LLBZPESJRQGYMB-UHFFFAOYSA-N 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000006547 cyclononyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- SEPPVOUBHWNCAW-FNORWQNLSA-N (E)-4-oxonon-2-enal Chemical compound CCCCCC(=O)\C=C\C=O SEPPVOUBHWNCAW-FNORWQNLSA-N 0.000 claims description 2
- 239000004305 biphenyl Substances 0.000 claims description 2
- 125000004306 triazinyl group Chemical group 0.000 claims description 2
- 102000048266 Nociceptin Human genes 0.000 claims 4
- AWGBKZRMLNVLAF-UHFFFAOYSA-N 3,5-dibromo-n,2-dihydroxybenzamide Chemical compound ONC(=O)C1=CC(Br)=CC(Br)=C1O AWGBKZRMLNVLAF-UHFFFAOYSA-N 0.000 claims 1
- 125000005508 decahydronaphthalenyl group Chemical group 0.000 claims 1
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims 1
- BNRNAKTVFSZAFA-UHFFFAOYSA-N hydrindane Chemical group C1CCCC2CCCC21 BNRNAKTVFSZAFA-UHFFFAOYSA-N 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 238000007429 general method Methods 0.000 description 74
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 63
- MCXBIZXYNQHVCM-UHFFFAOYSA-N decan-4-one;hydrochloride Chemical compound Cl.CCCCCCC(=O)CCC MCXBIZXYNQHVCM-UHFFFAOYSA-N 0.000 description 58
- 239000007787 solid Substances 0.000 description 52
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 46
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
- PBIUDEUWYGBHDW-UHFFFAOYSA-N 2-chloro-1-pyridin-3-ylethanone;hydrochloride Chemical compound Cl.ClCC(=O)C1=CC=CN=C1 PBIUDEUWYGBHDW-UHFFFAOYSA-N 0.000 description 27
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 26
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 23
- 229940093499 ethyl acetate Drugs 0.000 description 21
- 235000019439 ethyl acetate Nutrition 0.000 description 21
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 19
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 19
- 239000011541 reaction mixture Substances 0.000 description 19
- 229910052938 sodium sulfate Inorganic materials 0.000 description 19
- 235000011152 sodium sulphate Nutrition 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- SXOZDDAFVJANJP-UHFFFAOYSA-N cyclodecanone Chemical compound O=C1CCCCCCCCC1 SXOZDDAFVJANJP-UHFFFAOYSA-N 0.000 description 14
- NNFCIYWJLLJEMN-UHFFFAOYSA-N dec-2-en-4-one Chemical compound CCCCCCC(=O)C=CC NNFCIYWJLLJEMN-UHFFFAOYSA-N 0.000 description 12
- 239000012074 organic phase Substances 0.000 description 11
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- LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 description 8
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- 125000004135 2-norbornyl group Chemical group [H]C1([H])C([H])([H])C2([H])C([H])([H])C1([H])C([H])([H])C2([H])* 0.000 description 2
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- LVKCSZQWLOVUGB-UHFFFAOYSA-M magnesium;propane;bromide Chemical compound [Mg+2].[Br-].C[CH-]C LVKCSZQWLOVUGB-UHFFFAOYSA-M 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000008012 organic excipient Substances 0.000 description 1
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- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- PBWOAHPCJMFKNX-UHFFFAOYSA-N spiro[4.5]decan-4-one Chemical compound O=C1CCCC11CCCCC1.O=C1CCCC11CCCCC1 PBWOAHPCJMFKNX-UHFFFAOYSA-N 0.000 description 1
- FEYUTRZPSFLEST-UHFFFAOYSA-N spiro[5.5]undecan-4-one Chemical compound C1C(=O)CCCC11CCCCC1 FEYUTRZPSFLEST-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- HTSABYAWKQAHBT-UHFFFAOYSA-N trans 3-methylcyclohexanol Natural products CC1CCCC(O)C1 HTSABYAWKQAHBT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Color Printing (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP97121427 | 1997-12-05 | ||
EP97121427 | 1997-12-05 |
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AU9608798A AU9608798A (en) | 1999-06-24 |
AU744338B2 true AU744338B2 (en) | 2002-02-21 |
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AU96087/98A Ceased AU744338B2 (en) | 1997-12-05 | 1998-12-04 | 1,3,8-triazaspiro(4.5)decan-4-one derivatives |
Country Status (29)
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US (1) | US6043366A (cs) |
JP (1) | JP3366868B2 (cs) |
KR (1) | KR19990062800A (cs) |
CN (1) | CN1118467C (cs) |
AR (1) | AR016428A1 (cs) |
AT (1) | ATE212635T1 (cs) |
AU (1) | AU744338B2 (cs) |
BR (1) | BR9805297B1 (cs) |
CA (1) | CA2255171C (cs) |
CO (1) | CO4990965A1 (cs) |
CZ (1) | CZ399698A3 (cs) |
DE (1) | DE69803653T2 (cs) |
DK (1) | DK0921125T3 (cs) |
ES (1) | ES2170446T3 (cs) |
HR (1) | HRP980613A2 (cs) |
HU (1) | HUP9802807A3 (cs) |
ID (1) | ID21413A (cs) |
IL (1) | IL127399A0 (cs) |
MA (1) | MA26573A1 (cs) |
NO (1) | NO312161B1 (cs) |
NZ (1) | NZ333159A (cs) |
PE (1) | PE135299A1 (cs) |
PL (1) | PL330062A1 (cs) |
PT (1) | PT921125E (cs) |
SG (1) | SG71173A1 (cs) |
TR (1) | TR199802520A3 (cs) |
TW (1) | TW408123B (cs) |
YU (1) | YU55198A (cs) |
ZA (1) | ZA9811128B (cs) |
Families Citing this family (19)
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ATE289307T1 (de) * | 1998-10-23 | 2005-03-15 | Pfizer | 1,3,8-triazaspiro(4,5) decanon verbindungen als orl1-receptor agonisten |
JP3989247B2 (ja) * | 1999-12-06 | 2007-10-10 | ユーロ−セルティーク エス.エイ. | ノシセプチン受容体親和性を有するトリアゾスピロ化合物 |
US7192964B2 (en) * | 2001-07-23 | 2007-03-20 | Banyu Pharmaceutical Co., Ltd. | 4-oxoimidazolidine-2-spiropiperidine derivatives |
ES2392340T3 (es) | 2002-03-29 | 2012-12-07 | Mitsubishi Tanabe Pharma Corporation | Remedio para los trastornos del sueño |
EP1601674B1 (en) * | 2002-09-09 | 2012-08-08 | Janssen Pharmaceutica NV | Hydroxyalkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
AU2003299791A1 (en) * | 2002-12-20 | 2004-07-22 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
ZA200510329B (en) * | 2003-05-23 | 2007-04-25 | Zealand Pharma As | Triaza-spiro compounds as nociceptin analogues and uses thereof |
US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
CN101146801A (zh) * | 2005-03-22 | 2008-03-19 | 霍夫曼-拉罗奇有限公司 | 新型的dpp-iv抑制剂的盐和多晶型物 |
US20070299072A1 (en) * | 2006-06-20 | 2007-12-27 | Wyeth | Kv1.5 potassium channel inhibitors |
MX2009005641A (es) * | 2006-11-28 | 2009-06-05 | Janssen Pharmaceutica Nv | Sales de 3-(3-amino-2-(r)-hidroxi-propil)-1-(4-fluoro-fenil)-8-(8- metil-naftalen-1-ilmetil)-1,3,8-triaza-espiro[4,5]deca n-4-ona. |
BRPI0808025A2 (pt) * | 2007-03-01 | 2014-06-24 | Mitsubishi Tanabe Pharma Corp | Composto de benzimidazol e uso farmacêutico do mesmo |
EP2150552B1 (en) * | 2007-04-09 | 2013-01-02 | Janssen Pharmaceutica NV | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
PA8801401A1 (es) * | 2007-10-25 | 2009-05-15 | Janssen Pharmaceutica Nv | Arilindenopirimidinas y su uso como adenosina a2a |
TW201016675A (en) * | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
US20100076003A1 (en) * | 2008-09-19 | 2010-03-25 | Kathleen Battista | 5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators |
WO2010037081A1 (en) * | 2008-09-29 | 2010-04-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific spiro-piperidine compounds |
AU2010260381B2 (en) | 2009-06-16 | 2013-10-24 | Merck Sharp & Dohme Corp. | Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones |
CN107849044B (zh) * | 2015-07-03 | 2021-06-25 | 豪夫迈·罗氏有限公司 | 作为ddr1抑制剂的三氮杂-螺癸酮类化合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0035902A1 (en) * | 1980-03-10 | 1981-09-16 | Janssen Pharmaceutica N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives |
EP0856514A1 (en) * | 1997-01-30 | 1998-08-05 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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US3161644A (en) * | 1962-06-22 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-benzyl-4-substituted piperidines |
US3155669A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 2, 4, 8-triaza-spiro (4, 5) dec-2-enes |
US3155670A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes |
US3238216A (en) * | 1963-06-20 | 1966-03-01 | Res Lab Dr C Janssen N V | Substituted 1, 3, 8-triaza-spiro (4, 5) decanes |
JPS5212171A (en) * | 1975-07-17 | 1977-01-29 | Yoshitomi Pharmaceut Ind Ltd | Process for preparation of cyclohexane derivatives |
GB1486546A (en) * | 1975-02-28 | 1977-09-21 | Yoshitomo Pharma Ind Ltd | 4,4-diphenyl-cyclohexylpiperidine compounds and analogues thereof |
JPS51100084A (cs) * | 1975-02-28 | 1976-09-03 | Yoshitomi Pharmaceutical | |
JPS5934713B2 (ja) * | 1976-01-05 | 1984-08-24 | ウェルファイド株式会社 | 脂環式誘導体 |
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JPS6012357B2 (ja) * | 1984-01-23 | 1985-04-01 | 吉富製薬株式会社 | 脂環式誘導体 |
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1998
- 1998-11-27 DE DE69803653T patent/DE69803653T2/de not_active Expired - Lifetime
- 1998-11-27 AT AT98122511T patent/ATE212635T1/de active
- 1998-11-27 DK DK98122511T patent/DK0921125T3/da active
- 1998-11-27 ES ES98122511T patent/ES2170446T3/es not_active Expired - Lifetime
- 1998-11-27 PT PT98122511T patent/PT921125E/pt unknown
- 1998-12-03 US US09/204,184 patent/US6043366A/en not_active Expired - Fee Related
- 1998-12-03 PE PE1998001176A patent/PE135299A1/es not_active Application Discontinuation
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- 1998-12-03 YU YU55198A patent/YU55198A/sh unknown
- 1998-12-03 ID IDP981576A patent/ID21413A/id unknown
- 1998-12-04 HR HR97121427.5A patent/HRP980613A2/hr not_active Application Discontinuation
- 1998-12-04 CZ CZ983996A patent/CZ399698A3/cs unknown
- 1998-12-04 AU AU96087/98A patent/AU744338B2/en not_active Ceased
- 1998-12-04 CO CO98072457A patent/CO4990965A1/es unknown
- 1998-12-04 KR KR1019980053080A patent/KR19990062800A/ko active Search and Examination
- 1998-12-04 IL IL12739998A patent/IL127399A0/xx unknown
- 1998-12-04 HU HU9802807A patent/HUP9802807A3/hu unknown
- 1998-12-04 BR BRPI9805297-7A patent/BR9805297B1/pt not_active IP Right Cessation
- 1998-12-04 MA MA25369A patent/MA26573A1/fr unknown
- 1998-12-04 JP JP34527898A patent/JP3366868B2/ja not_active Expired - Fee Related
- 1998-12-04 TW TW087120132A patent/TW408123B/zh not_active IP Right Cessation
- 1998-12-04 TR TR1998/02520A patent/TR199802520A3/tr unknown
- 1998-12-04 ZA ZA9811128A patent/ZA9811128B/xx unknown
- 1998-12-04 NO NO19985684A patent/NO312161B1/no not_active IP Right Cessation
- 1998-12-04 CN CN98122759A patent/CN1118467C/zh not_active Expired - Fee Related
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Publication number | Priority date | Publication date | Assignee | Title |
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EP0035902A1 (en) * | 1980-03-10 | 1981-09-16 | Janssen Pharmaceutica N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives |
EP0856514A1 (en) * | 1997-01-30 | 1998-08-05 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives |
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