AU718597B2 - Indoline derivatives useful as 5-HT-2C receptor antagonists - Google Patents

Indoline derivatives useful as 5-HT-2C receptor antagonists Download PDF

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Publication number
AU718597B2
AU718597B2 AU32602/97A AU3260297A AU718597B2 AU 718597 B2 AU718597 B2 AU 718597B2 AU 32602/97 A AU32602/97 A AU 32602/97A AU 3260297 A AU3260297 A AU 3260297A AU 718597 B2 AU718597 B2 AU 718597B2
Authority
AU
Australia
Prior art keywords
compound according
compound
formula
disorders
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU32602/97A
Other languages
English (en)
Other versions
AU3260297A (en
Inventor
Steven Mark Bromidge
Ian Thomson Forbes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU3260297A publication Critical patent/AU3260297A/en
Application granted granted Critical
Publication of AU718597B2 publication Critical patent/AU718597B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU32602/97A 1996-06-20 1997-06-16 Indoline derivatives useful as 5-HT-2C receptor antagonists Ceased AU718597B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9612883 1996-06-20
GBGB9612883.0A GB9612883D0 (en) 1996-06-20 1996-06-20 Novel compounds
PCT/EP1997/003156 WO1997048699A1 (en) 1996-06-20 1997-06-16 Indoline derivatives useful as 5-ht-2c receptor antagonists

Publications (2)

Publication Number Publication Date
AU3260297A AU3260297A (en) 1998-01-07
AU718597B2 true AU718597B2 (en) 2000-04-20

Family

ID=10795575

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32602/97A Ceased AU718597B2 (en) 1996-06-20 1997-06-16 Indoline derivatives useful as 5-HT-2C receptor antagonists

Country Status (33)

Country Link
US (1) US6369060B1 (enExample)
EP (1) EP0912554B1 (enExample)
JP (1) JP2000512306A (enExample)
KR (1) KR20000022045A (enExample)
CN (1) CN1229408A (enExample)
AP (2) AP9801410A0 (enExample)
AR (1) AR008243A1 (enExample)
AT (1) ATE228514T1 (enExample)
AU (1) AU718597B2 (enExample)
BG (1) BG103089A (enExample)
BR (1) BR9709911A (enExample)
CA (1) CA2258240A1 (enExample)
CO (1) CO4890847A1 (enExample)
CZ (1) CZ420598A3 (enExample)
DE (1) DE69717449T2 (enExample)
DZ (1) DZ2250A1 (enExample)
EA (1) EA001780B1 (enExample)
ES (1) ES2187783T3 (enExample)
GB (1) GB9612883D0 (enExample)
HU (1) HUP9903439A3 (enExample)
ID (1) ID19433A (enExample)
IL (1) IL127417A0 (enExample)
MA (1) MA24214A1 (enExample)
NO (1) NO985972L (enExample)
NZ (1) NZ333229A (enExample)
OA (1) OA10944A (enExample)
PE (1) PE86698A1 (enExample)
PL (1) PL330796A1 (enExample)
SK (1) SK282706B6 (enExample)
TR (1) TR199802661T2 (enExample)
TW (1) TW382015B (enExample)
WO (1) WO1997048699A1 (enExample)
ZA (1) ZA975415B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043650A2 (en) * 1998-02-25 1999-09-02 Smithkline Beecham Plc Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
JP2005535560A (ja) * 2001-11-28 2005-11-24 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療用の化合物
MXPA04008517A (es) * 2002-03-04 2005-08-19 Pharmacia & Upjohn Co Llc Compuestos terapeuticos.
KR101062376B1 (ko) * 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
CN102348798A (zh) 2009-01-16 2012-02-08 麻省理工学院 孤独症谱系障碍的诊断和治疗
EP2651403B1 (en) 2010-12-17 2020-12-02 Glaxo Group Limited Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
WO2014046544A1 (en) 2012-09-21 2014-03-27 Aapa B.V. Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4664696A (en) * 1995-02-02 1996-08-21 Smithkline Beecham Plc Indole derivatives as 5-ht receptor antagonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
CA2142721A1 (en) * 1992-08-20 1994-03-03 Ian T. Forbes Condensed indole derivatives as 5ht and 5ht antagonists
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9615767D0 (en) * 1996-07-26 1996-09-04 Smithkline Beecham Plc Novel treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4664696A (en) * 1995-02-02 1996-08-21 Smithkline Beecham Plc Indole derivatives as 5-ht receptor antagonist

Also Published As

Publication number Publication date
AP745A (en) 1999-04-28
KR20000022045A (ko) 2000-04-25
CN1229408A (zh) 1999-09-22
MA24214A1 (fr) 1997-12-31
CA2258240A1 (en) 1997-12-24
AP9801410A0 (en) 1998-12-31
CZ420598A3 (cs) 1999-06-16
EP0912554A1 (en) 1999-05-06
NZ333229A (enExample) 2000-01-28
AP9701037A0 (en) 1997-07-31
BR9709911A (pt) 1999-08-10
HUP9903439A3 (en) 2002-12-28
DE69717449T2 (de) 2003-10-02
ID19433A (id) 1998-07-09
TW382015B (en) 2000-02-11
ZA975415B (en) 1998-12-21
OA10944A (en) 2003-02-27
ES2187783T3 (es) 2003-06-16
GB9612883D0 (en) 1996-08-21
AR008243A1 (es) 1999-12-29
PE86698A1 (es) 1999-01-28
BG103089A (en) 1999-09-30
DE69717449D1 (de) 2003-01-09
PL330796A1 (en) 1999-06-07
SK282706B6 (sk) 2002-11-06
SK175298A3 (en) 1999-05-07
JP2000512306A (ja) 2000-09-19
EP0912554B1 (en) 2002-11-27
EA001780B1 (ru) 2001-08-27
EA199900043A1 (ru) 1999-06-24
DZ2250A1 (fr) 2002-12-18
HUP9903439A2 (en) 2000-07-28
TR199802661T2 (xx) 1999-03-22
IL127417A0 (en) 1999-10-28
WO1997048699A1 (en) 1997-12-24
CO4890847A1 (es) 2000-02-28
ATE228514T1 (de) 2002-12-15
AU3260297A (en) 1998-01-07
US6369060B1 (en) 2002-04-09
NO985972D0 (no) 1998-12-18
NO985972L (no) 1998-12-18

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired