AU712581B2 - Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins - Google Patents

Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins Download PDF

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Publication number
AU712581B2
AU712581B2 AU53714/96A AU5371496A AU712581B2 AU 712581 B2 AU712581 B2 AU 712581B2 AU 53714/96 A AU53714/96 A AU 53714/96A AU 5371496 A AU5371496 A AU 5371496A AU 712581 B2 AU712581 B2 AU 712581B2
Authority
AU
Australia
Prior art keywords
sheet
warm
mmol
solution
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU53714/96A
Other languages
English (en)
Other versions
AU5371496A (en
Inventor
Michael Kahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecumetics Ltd
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Publication of AU5371496A publication Critical patent/AU5371496A/en
Application granted granted Critical
Publication of AU712581B2 publication Critical patent/AU712581B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Paper (AREA)
AU53714/96A 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins Ceased AU712581B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41051895A 1995-03-24 1995-03-24
US08/410518 1995-03-24
US54900695A 1995-10-27 1995-10-27
US08/549006 1995-10-27
PCT/US1996/004044 WO1996030035A1 (en) 1995-03-24 1996-03-25 β-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU16374/00A Division AU733205B2 (en) 1995-03-24 2000-02-11 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins

Publications (2)

Publication Number Publication Date
AU5371496A AU5371496A (en) 1996-10-16
AU712581B2 true AU712581B2 (en) 1999-11-11

Family

ID=27021026

Family Applications (2)

Application Number Title Priority Date Filing Date
AU53714/96A Ceased AU712581B2 (en) 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
AU53729/96A Ceased AU713530B2 (en) 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as protease inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU53729/96A Ceased AU713530B2 (en) 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as protease inhibitors

Country Status (8)

Country Link
EP (2) EP0815123B1 (enExample)
JP (4) JPH10508035A (enExample)
AT (1) ATE206433T1 (enExample)
AU (2) AU712581B2 (enExample)
CA (2) CA2215695C (enExample)
DE (1) DE69615671T2 (enExample)
ES (1) ES2161354T3 (enExample)
WO (1) WO1996030035A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
WO1997016425A1 (en) * 1995-10-30 1997-05-09 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
US6541453B2 (en) 1996-06-07 2003-04-01 Syngenta Limited Peptide derivatives
WO1997048687A1 (en) * 1996-06-18 1997-12-24 Warner-Lambert Company Process for the preparation of chiral keto-heterocycles of basic amino acids
JP2001524931A (ja) * 1996-08-05 2001-12-04 モレキュメティクス リミテッド プロテアーゼおよびキナーゼのインヒビターとしてならびに転写因子のインヒビターとしてのβシート模倣物の使用
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
GB9621836D0 (en) 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
GB9625865D0 (en) * 1996-12-12 1997-01-29 Zeneca Ltd Peptides
EP1053246B1 (en) * 1998-02-12 2003-01-02 Molecumetics, Ltd. Beta-sheet mimetics and methods relating to the use thereof
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
YU61401A (sh) 1999-01-27 2005-07-19 Orto-Mcneil Pharmaceuticals Inc. U.S. Peptidil heterociklični ketoni korisni kao inhibitori triptaze
US7309688B2 (en) 2000-10-27 2007-12-18 Johnson & Johnson Consumer Companies Topical anti-cancer compositions and methods of use thereof
US6699855B2 (en) * 2000-02-29 2004-03-02 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus NS3 protease
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
WO2011096440A1 (ja) 2010-02-03 2011-08-11 ＰＲＩＳＭ ＢｉｏＬａｂ株式会社 天然変性タンパク質に結合する化合物およびそのスクリーニング方法
RU2728785C2 (ru) 2014-10-06 2020-07-31 Кортексим, Инк. Ингибиторы лизинспецифичного гингипаина
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
CN109983012B (zh) 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896851B (en) * 1988-09-14 1990-06-27 Hoffmann La Roche Use of ace-inhibitors

Also Published As

Publication number Publication date
AU713530B2 (en) 1999-12-02
EP0817642A1 (en) 1998-01-14
ES2161354T3 (es) 2001-12-01
EP0815123A1 (en) 1998-01-07
CA2215695C (en) 2003-09-16
JP2000319295A (ja) 2000-11-21
AU5372996A (en) 1996-10-16
DE69615671D1 (de) 2001-11-08
ATE206433T1 (de) 2001-10-15
CA2215695A1 (en) 1996-10-03
DE69615671T2 (de) 2002-08-08
AU5371496A (en) 1996-10-16
WO1996030035A1 (en) 1996-10-03
JP2004131511A (ja) 2004-04-30
JPH10508034A (ja) 1998-08-04
JP4152900B2 (ja) 2008-09-17
JPH10508035A (ja) 1998-08-04
CA2215720A1 (en) 1996-10-03
EP0815123B1 (en) 2001-10-04

Similar Documents

Publication Publication Date Title
AU712581B2 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
AU732174B2 (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US6245764B1 (en) β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6372744B1 (en) β-sheet mimetics and methods relating to the use thereof
WO1996030396A1 (en) β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
US6586426B1 (en) β-sheet mimetics and use thereof as protease inhibitors
AU748887B2 (en) Beta-sheet mimetics and methods relating to the use thereof
US6699869B1 (en) β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
AU733205B2 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US20030191109A1 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
AU5421301A (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
EP1661566A2 (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired