AU696622B2 - Inhibitors of phosphoinositide-specific phospholipase C - Google Patents

Inhibitors of phosphoinositide-specific phospholipase C

Info

Publication number
AU696622B2
AU696622B2 AU79738/94A AU7973894A AU696622B2 AU 696622 B2 AU696622 B2 AU 696622B2 AU 79738/94 A AU79738/94 A AU 79738/94A AU 7973894 A AU7973894 A AU 7973894A AU 696622 B2 AU696622 B2 AU 696622B2
Authority
AU
Australia
Prior art keywords
hydrogen
glu
leu
mammal
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79738/94A
Other languages
English (en)
Other versions
AU7973894A (en
Inventor
Jackson B Gibbs
Kenneth S Koblan
Angus M MacLeod
Kevin J. Merchant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU7973894A publication Critical patent/AU7973894A/en
Application granted granted Critical
Publication of AU696622B2 publication Critical patent/AU696622B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU79738/94A 1993-10-15 1994-10-11 Inhibitors of phosphoinositide-specific phospholipase C Ceased AU696622B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/138,133 US5519163A (en) 1993-10-15 1993-10-15 Inhibitors of phosphoinositide-specific phospholipase C
US138133 1993-10-15
PCT/US1994/011497 WO1995010286A1 (en) 1993-10-15 1994-10-11 Inhibitors of phosphoinositide-specific phospholipase c

Publications (2)

Publication Number Publication Date
AU7973894A AU7973894A (en) 1995-05-04
AU696622B2 true AU696622B2 (en) 1998-09-17

Family

ID=22480566

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79738/94A Ceased AU696622B2 (en) 1993-10-15 1994-10-11 Inhibitors of phosphoinositide-specific phospholipase C

Country Status (6)

Country Link
US (1) US5519163A (OSRAM)
EP (1) EP0746323A1 (OSRAM)
JP (1) JPH09505033A (OSRAM)
AU (1) AU696622B2 (OSRAM)
CA (1) CA2173456A1 (OSRAM)
WO (1) WO1995010286A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1754480T3 (da) 2000-10-10 2011-05-16 Univ North Carolina Sammensætninger omfattende phospholipase-c-inhibitorer samt fremgangsmåde til forbedring af paracellulær permeabilitet gennem epitel- og endothelial-barrierer
US20020107193A1 (en) * 2000-11-09 2002-08-08 Glazner Gordon W. Therapeutic uses for IP3 receptor-mediated calcium channel modulators
US20060128667A1 (en) * 2002-05-11 2006-06-15 Montes Imber F Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
WO2005051298A2 (en) * 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
WO2006128058A2 (en) 2005-05-26 2006-11-30 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
EP1566447A1 (en) * 2004-02-20 2005-08-24 Aventis Pharma Deutschland GmbH Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
EP1896039A2 (en) * 2005-06-07 2008-03-12 The Regents of the University of California Inhibition of epac, phospholipase c ''epsilon'', and phospholipase d to treat pain
EP2825887A4 (en) * 2012-03-15 2015-08-19 Montana Molecular Llc GENETICALLY-CODED, FLUORESCENT SENSORS FOR THE DETECTION OF INTRA-CELLULAR SIGNALS BY DIACYLGLYCEROL SIGNAL PATHS
EP3738971B1 (en) 2013-11-04 2024-07-17 Montana Molecular LLC Genetically encoded fluorescent sensors for detecting ligand bias and intracellular signaling through camp pathways
AU2017363206A1 (en) 2016-11-21 2019-06-13 Viking Therapeutics, Inc. Method of treating glycogen storage disease
EP3634426A4 (en) 2017-06-05 2021-04-07 Viking Therapeutics, Inc. COMPOSITIONS FOR TREATMENT OF FIBROSE
MX2020009843A (es) 2018-03-22 2020-12-11 Viking Therapeutics Inc Formas cristalinas y metodos de produccion de formas cristalinas de un compuesto.
CN109516623B (zh) * 2018-11-16 2021-06-01 浙江万盛股份有限公司 一种三丁氧乙基磷酸酯废水的综合利用方法
WO2020117962A1 (en) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474806A (en) * 1982-05-10 1984-10-02 Merck & Co., Inc. Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEM. ABS, 118, 1993, 39033T *

Also Published As

Publication number Publication date
JPH09505033A (ja) 1997-05-20
US5519163A (en) 1996-05-21
CA2173456A1 (en) 1995-04-20
EP0746323A1 (en) 1996-12-11
EP0746323A4 (OSRAM) 1997-01-22
WO1995010286A1 (en) 1995-04-20
AU7973894A (en) 1995-05-04

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired