AU696622B2 - Inhibitors of phosphoinositide-specific phospholipase C - Google Patents

Inhibitors of phosphoinositide-specific phospholipase C

Info

Publication number
AU696622B2
AU696622B2 AU79738/94A AU7973894A AU696622B2 AU 696622 B2 AU696622 B2 AU 696622B2 AU 79738/94 A AU79738/94 A AU 79738/94A AU 7973894 A AU7973894 A AU 7973894A AU 696622 B2 AU696622 B2 AU 696622B2
Authority
AU
Australia
Prior art keywords
hydrogen
glu
leu
mammal
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79738/94A
Other languages
English (en)
Other versions
AU7973894A (en
Inventor
Jackson B Gibbs
Kenneth S Koblan
Angus M MacLeod
Kevin J. Merchant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU7973894A publication Critical patent/AU7973894A/en
Application granted granted Critical
Publication of AU696622B2 publication Critical patent/AU696622B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU79738/94A 1993-10-15 1994-10-11 Inhibitors of phosphoinositide-specific phospholipase C Ceased AU696622B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/138,133 US5519163A (en) 1993-10-15 1993-10-15 Inhibitors of phosphoinositide-specific phospholipase C
PCT/US1994/011497 WO1995010286A1 (en) 1993-10-15 1994-10-11 Inhibitors of phosphoinositide-specific phospholipase c
US138133 1998-08-21

Publications (2)

Publication Number Publication Date
AU7973894A AU7973894A (en) 1995-05-04
AU696622B2 true AU696622B2 (en) 1998-09-17

Family

ID=22480566

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79738/94A Ceased AU696622B2 (en) 1993-10-15 1994-10-11 Inhibitors of phosphoinositide-specific phospholipase C

Country Status (6)

Country Link
US (1) US5519163A (OSRAM)
EP (1) EP0746323A1 (OSRAM)
JP (1) JPH09505033A (OSRAM)
AU (1) AU696622B2 (OSRAM)
CA (1) CA2173456A1 (OSRAM)
WO (1) WO1995010286A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE348622T1 (de) 2000-10-10 2007-01-15 Univ North Carolina Zusammensetzungen enthaltend phospholipase c inhibitoren und verfahren zur erhöhung parazellulärer permeabilität der epithelbarriere und endothelbarriere
US20020107193A1 (en) * 2000-11-09 2002-08-08 Glazner Gordon W. Therapeutic uses for IP3 receptor-mediated calcium channel modulators
WO2003094852A2 (en) * 2002-05-11 2003-11-20 Ilex Products, Inc. Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
CA2546601A1 (en) * 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
EP1566447A1 (en) * 2004-02-20 2005-08-24 Aventis Pharma Deutschland GmbH Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
US20090232879A1 (en) 2005-05-26 2009-09-17 Metabasis Therapeutics, Inc. Thyromimetics for the Treatment of Fatty Liver Diseases
EP1896039A2 (en) * 2005-06-07 2008-03-12 The Regents of the University of California Inhibition of epac, phospholipase c ''epsilon'', and phospholipase d to treat pain
WO2013138684A1 (en) 2012-03-15 2013-09-19 Montana Molecular Llc Genetically encoded fluorescent sensors for detecting intracellular signalling through diacylglycerol pathways
CA2929392A1 (en) 2013-11-04 2015-05-07 Montana Molecular Llc Genetically encoded fluorescent sensors for detecting ligand bias and intracellular signaling through camp pathways
BR112019010249A2 (pt) 2016-11-21 2019-09-10 Viking Therapeutics Inc método de tratamento de doença de armazenamento de glicogênio
US11707472B2 (en) 2017-06-05 2023-07-25 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
US11787828B2 (en) 2018-03-22 2023-10-17 Viking Therapeutics, Inc. Crystalline forms and methods of producing crystalline forms of a compound
CN109516623B (zh) * 2018-11-16 2021-06-01 浙江万盛股份有限公司 一种三丁氧乙基磷酸酯废水的综合利用方法
WO2020117962A1 (en) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474806A (en) * 1982-05-10 1984-10-02 Merck & Co., Inc. Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEM. ABS, 118, 1993, 39033T *

Also Published As

Publication number Publication date
US5519163A (en) 1996-05-21
AU7973894A (en) 1995-05-04
JPH09505033A (ja) 1997-05-20
WO1995010286A1 (en) 1995-04-20
CA2173456A1 (en) 1995-04-20
EP0746323A1 (en) 1996-12-11
EP0746323A4 (OSRAM) 1997-01-22

Similar Documents

Publication Publication Date Title
AU696622B2 (en) Inhibitors of phosphoinositide-specific phospholipase C
Byrum et al. Role of the 5-lipoxygenase–activating protein (FLAP) in murine acute inflammatory responses
JP4102445B2 (ja) 脂肪酸アミドヒドロラーゼ
US5955583A (en) Antibodies to cGMP-binding, cGMP-specific phospodiesterase
US5593878A (en) Recombinant phospholipase A2 enzyme
US5994503A (en) Nucleotide and protein sequences of lats genes and methods based thereon
US20080076141A1 (en) Novel murine and human kinases
FR2474505A1 (fr) Derives d'acide hydroxyaminophosphoniques hydrocarbones, leurs preparations et leurs utilisations comme agents ayant une activite antimicrobienne contre des micro-organismes pathogenes
US5554511A (en) Calcium independent cytosolic phospholipase A2 /B enzymes
JP2002515020A (ja) ＴＮＦ−α転換酵素
EP0793721B1 (fr) Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation
CN113604453A (zh) 一种海洋链霉菌磷脂酶d突变体和应用
US6187559B1 (en) Phospholipase D gene
CA1052810A (en) .omega.-(N-ACYLAMINO) ALKYLPHOSPHORYL ETHANOLAMINES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USES
US5474921A (en) Expression and purification of phosphoinositide-specific phospholipase C-γ
US6812017B2 (en) Mammalian secreted group IIF phospholipase A2
US6645736B2 (en) Calcium independent cytosolic phospholipase A2/B enzymes
WO1997017448A2 (en) Calcium independent cytosolic phospholipase a2/b enzymes
WO2000052043A1 (en) Polypeptide having antihuman immunodeficiency virus activity, gene encoding the polypeptide and process for producing the polypeptide
JP2002537814A (ja) ヒスチジン・プロテイン・ホスファターゼ
US20040053229A1 (en) Mammalian protein phosphatases
KR100236472B1 (ko) 파네실 전이효소 저해제로 유용한 트로판 유도체
JPH028716B2 (OSRAM)
JPH01187095A (ja) アミノ亜ホスホン酸の分割方法
AU664752B2 (en) Receptor-type tyrosine kinase-like molecules

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired