AU6895598A - Combinatorial libraries of peptidomimetic macrocycles and processes therefor - Google Patents
Combinatorial libraries of peptidomimetic macrocycles and processes thereforInfo
- Publication number
- AU6895598A AU6895598A AU68955/98A AU6895598A AU6895598A AU 6895598 A AU6895598 A AU 6895598A AU 68955/98 A AU68955/98 A AU 68955/98A AU 6895598 A AU6895598 A AU 6895598A AU 6895598 A AU6895598 A AU 6895598A
- Authority
- AU
- Australia
- Prior art keywords
- combinatorial libraries
- peptidomimetic macrocycles
- processes therefor
- therefor
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4353297P | 1997-04-11 | 1997-04-11 | |
US60043532 | 1997-04-11 | ||
PCT/US1998/007135 WO1998046631A1 (en) | 1997-04-11 | 1998-04-08 | Combinatorial libraries of peptidomimetic macrocycles and processes therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
AU6895598A true AU6895598A (en) | 1998-11-11 |
Family
ID=21927649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU68955/98A Abandoned AU6895598A (en) | 1997-04-11 | 1998-04-08 | Combinatorial libraries of peptidomimetic macrocycles and processes therefor |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1015479A4 (ja) |
JP (1) | JP2002506423A (ja) |
AU (1) | AU6895598A (ja) |
CA (1) | CA2286867A1 (ja) |
WO (1) | WO1998046631A1 (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
CA2284459C (en) | 1999-10-04 | 2012-12-11 | Neokimia Inc. | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery |
WO2004111077A1 (en) | 2003-06-18 | 2004-12-23 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor |
DK1648922T3 (da) | 2003-07-31 | 2011-03-14 | Tranzyme Pharma Inc | Rumligt definerede makrocykliske forbindelser, der er anvendelige til opdagelse af lægemidler |
US7550431B2 (en) * | 2003-07-31 | 2009-06-23 | Tranzyme Pharma Inc. | Spatially-defined macrocycles incorporating peptide bond surrogates |
US8088733B2 (en) | 2006-07-06 | 2012-01-03 | Tranzyme Pharma Inc. | Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders |
US7981998B2 (en) | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
US7960506B2 (en) * | 2006-12-14 | 2011-06-14 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
PT2118123E (pt) | 2007-01-31 | 2016-02-10 | Harvard College | Péptidos de p53 estabilizados e suas utilizações |
CN109627287A (zh) | 2007-02-23 | 2019-04-16 | 爱勒让治疗公司 | 三唑大环系统 |
WO2008121767A2 (en) | 2007-03-28 | 2008-10-09 | President And Fellows Of Harvard College | Stitched polypeptides |
EP2067787A1 (en) | 2007-12-06 | 2009-06-10 | Boehringer Ingelheim International GmbH | Method for controlling insect populations |
JP2012515172A (ja) | 2009-01-14 | 2012-07-05 | エルロン・セラピューティクス・インコーポレイテッド | ペプチド模倣大環状分子 |
JP2013505300A (ja) | 2009-09-22 | 2013-02-14 | エルロン・セラピューティクス・インコーポレイテッド | ペプチド模倣大環状分子 |
RU2582678C2 (ru) | 2010-08-13 | 2016-04-27 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
TWI643868B (zh) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | 擬肽巨環化合物 |
JP6450191B2 (ja) | 2012-02-15 | 2019-01-09 | エイルロン セラピューティクス,インコーポレイテッド | ペプチドミメティック大環状化合物 |
EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
KR102570210B1 (ko) | 2014-09-24 | 2023-08-23 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 제제 |
KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
JP2018516844A (ja) | 2015-03-20 | 2018-06-28 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
WO1994015958A2 (en) * | 1993-01-08 | 1994-07-21 | Tanabe Seiyaku Co., Ltd. | Peptide inhibitors of cell adhesion |
US7067326B2 (en) * | 1994-01-13 | 2006-06-27 | The Trustees Of Columbia University In The City Of New York | Synthetic receptors, libraries and uses thereof |
JPH10512570A (ja) * | 1995-01-20 | 1998-12-02 | モレキュメティックス リミテッド | コンホメーション的に制限された逆ターンライブラリおよびそれらに関連する方法 |
WO1996040781A1 (en) * | 1995-06-07 | 1996-12-19 | Tanabe Seiyaku Co., Ltd. | CYCLIC PEPTIDE INHIBITORS OF β1 AND β2 INTEGRIN-MEDIATED ADHESION |
-
1998
- 1998-04-08 EP EP98914651A patent/EP1015479A4/en not_active Withdrawn
- 1998-04-08 JP JP54406098A patent/JP2002506423A/ja active Pending
- 1998-04-08 AU AU68955/98A patent/AU6895598A/en not_active Abandoned
- 1998-04-08 CA CA002286867A patent/CA2286867A1/en not_active Abandoned
- 1998-04-08 WO PCT/US1998/007135 patent/WO1998046631A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002506423A (ja) | 2002-02-26 |
EP1015479A1 (en) | 2000-07-05 |
CA2286867A1 (en) | 1998-10-22 |
WO1998046631A1 (en) | 1998-10-22 |
EP1015479A4 (en) | 2002-07-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU6895598A (en) | Combinatorial libraries of peptidomimetic macrocycles and processes therefor | |
AU5374098A (en) | Combinatorial libraries of imidazol-pyrido-indoles and imidazol-pyrido-benzothiophene derivatives | |
AU2805995A (en) | Combinatorial peptide library and method | |
AU1741095A (en) | Generation and screening of synthetic drug libraries | |
AU9383198A (en) | Amine compounds and combinatorial libraries comprising same | |
AU8755798A (en) | Polyvalent and polyclonal libraries | |
AU2438595A (en) | Morpholino-subunit combinatorial library and method | |
AU6908398A (en) | Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones | |
AU2817297A (en) | Analysis of complex mixtures | |
HUP9901560A3 (en) | Mass-based encoding and qualitative analysis of combinatorial libraries | |
AU2001253147A1 (en) | Generation of combinatorial synthetic libraries and screening for proadhesins and nonadhesins | |
AU5893696A (en) | Modification of polypeptides | |
AU6381896A (en) | Peptide library and screening method | |
AU6241698A (en) | Tace-like and matrilysin-like polypeptides | |
AU1061997A (en) | Screening of drugs from chemical combinatorial libraries employing transponders | |
AU3272295A (en) | Soluble combinatorial libraries | |
AU1910299A (en) | Peptidomimetic template-based combinatorial libraries | |
AU2165000A (en) | Combinatorial discovery and testing of ionic liquids | |
AU5893796A (en) | Modification of polypeptides | |
AU6957098A (en) | Polyvalent presenter combinatorial libraries and their uses | |
AUPP737298A0 (en) | Combinatorial libraries | |
AU5243398A (en) | Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein | |
AU8147798A (en) | Peptido oligonucleotides (pons) and their combinatorial libraries | |
AU8849398A (en) | Combinatorial library | |
AU1093197A (en) | Combinatorial libraries |