AU684624B2 - Acridone-derived bisintercalators as chemotherapeutic agents - Google Patents
Acridone-derived bisintercalators as chemotherapeutic agentsInfo
- Publication number
- AU684624B2 AU684624B2 AU19900/95A AU1990095A AU684624B2 AU 684624 B2 AU684624 B2 AU 684624B2 AU 19900/95 A AU19900/95 A AU 19900/95A AU 1990095 A AU1990095 A AU 1990095A AU 684624 B2 AU684624 B2 AU 684624B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- nucleic acid
- sample
- detecting
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- FGWARXSCGJFBCM-UHFFFAOYSA-N wmc-42 Chemical compound C12=C3C(=O)C4=CC=CC=C4N1N=NC2=CC=C3NCCCN(C)CCCNC1=CC=C2C3=C1C(=O)C1=CC=CC=C1N3C=N2 FGWARXSCGJFBCM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0026—Acridine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/213,315 US5508289A (en) | 1994-03-14 | 1994-03-14 | Bis-acridone chemotherapeutic derivatives |
US213315 | 1994-03-14 | ||
PCT/US1995/003079 WO1995025093A1 (fr) | 1994-03-14 | 1995-03-09 | Composes intercalaires bifonctionnels derives d'acridone utilises en tant qu'agents chimiotherapeutiques |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1990095A AU1990095A (en) | 1995-10-03 |
AU684624B2 true AU684624B2 (en) | 1997-12-18 |
Family
ID=22794610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU19900/95A Ceased AU684624B2 (en) | 1994-03-14 | 1995-03-09 | Acridone-derived bisintercalators as chemotherapeutic agents |
Country Status (12)
Country | Link |
---|---|
US (1) | US5508289A (fr) |
EP (1) | EP0750612B1 (fr) |
JP (1) | JP3862747B2 (fr) |
AT (1) | ATE187716T1 (fr) |
AU (1) | AU684624B2 (fr) |
CA (1) | CA2185350C (fr) |
DE (1) | DE69513962T2 (fr) |
DK (1) | DK0750612T3 (fr) |
ES (1) | ES2140668T3 (fr) |
FI (1) | FI113369B (fr) |
GR (1) | GR3032836T3 (fr) |
WO (1) | WO1995025093A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0892801B1 (fr) * | 1996-04-12 | 2002-01-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Composes derives de l'acridone utiles en tant qu'agents antineoplasiques et antiretroviraux |
DE69820867T2 (de) * | 1997-04-29 | 2004-11-18 | Amersham Health As | Lichtbilderzeugungskontrastmitteln |
IT1293525B1 (it) * | 1997-08-01 | 1999-03-01 | Uni Degli Studi Camerino | Bis-acridincarbossiammidi aventi attivita' antitumorale |
CA2319495A1 (fr) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Inhibiteurs multiliaison de proteine triglyceride transferase microsomique |
JP5408829B2 (ja) | 1999-12-28 | 2014-02-05 | ゲットナー・ファンデーション・エルエルシー | アクティブマトリックス基板の製造方法 |
ES2387265T3 (es) * | 2001-01-31 | 2012-09-19 | Meiji Seika Kaisha Ltd. | Derivados de triazoquinolona como agentes para el control de plagas |
GB0208989D0 (en) | 2002-04-19 | 2002-05-29 | Amersham Biosciences Uk Ltd | Methods for measuring enzyme activity |
FR2879598B1 (fr) * | 2004-12-17 | 2007-03-30 | Sod Conseils Rech Applic | Inhibiteurs de phosphatases cdc25 |
PL3070078T3 (pl) * | 2015-03-20 | 2018-02-28 | Politechnika Gdańska | Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626540A (en) * | 1983-11-08 | 1986-12-02 | Warner-Lambert Company | Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them |
IL91673A0 (en) * | 1988-09-20 | 1990-04-29 | Us Health | Method for tagging an oligodeoxynucleotide |
GB9104548D0 (en) * | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
-
1994
- 1994-03-14 US US08/213,315 patent/US5508289A/en not_active Expired - Lifetime
-
1995
- 1995-03-09 EP EP95912887A patent/EP0750612B1/fr not_active Expired - Lifetime
- 1995-03-09 JP JP52411295A patent/JP3862747B2/ja not_active Expired - Fee Related
- 1995-03-09 AT AT95912887T patent/ATE187716T1/de not_active IP Right Cessation
- 1995-03-09 WO PCT/US1995/003079 patent/WO1995025093A1/fr active IP Right Grant
- 1995-03-09 CA CA002185350A patent/CA2185350C/fr not_active Expired - Fee Related
- 1995-03-09 DK DK95912887T patent/DK0750612T3/da active
- 1995-03-09 AU AU19900/95A patent/AU684624B2/en not_active Ceased
- 1995-03-09 DE DE69513962T patent/DE69513962T2/de not_active Expired - Fee Related
- 1995-03-09 ES ES95912887T patent/ES2140668T3/es not_active Expired - Lifetime
-
1996
- 1996-09-13 FI FI963626A patent/FI113369B/fi active
-
2000
- 2000-02-29 GR GR20000400528T patent/GR3032836T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3862747B2 (ja) | 2006-12-27 |
CA2185350C (fr) | 2006-01-03 |
EP0750612A1 (fr) | 1997-01-02 |
AU1990095A (en) | 1995-10-03 |
CA2185350A1 (fr) | 1995-09-21 |
DE69513962T2 (de) | 2000-06-21 |
FI963626A0 (fi) | 1996-09-13 |
ES2140668T3 (es) | 2000-03-01 |
EP0750612B1 (fr) | 1999-12-15 |
DK0750612T3 (da) | 2000-05-01 |
ATE187716T1 (de) | 2000-01-15 |
JPH09510451A (ja) | 1997-10-21 |
FI113369B (fi) | 2004-04-15 |
DE69513962D1 (de) | 2000-01-20 |
US5508289A (en) | 1996-04-16 |
FI963626A (fi) | 1996-11-08 |
GR3032836T3 (en) | 2000-07-31 |
WO1995025093A1 (fr) | 1995-09-21 |
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