AU683114B2 - Novel benzenesulfonylimine derivatives as inhibitors of IL-1 action - Google Patents
Novel benzenesulfonylimine derivatives as inhibitors of IL-1 action Download PDFInfo
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- AU683114B2 AU683114B2 AU10879/95A AU1087995A AU683114B2 AU 683114 B2 AU683114 B2 AU 683114B2 AU 10879/95 A AU10879/95 A AU 10879/95A AU 1087995 A AU1087995 A AU 1087995A AU 683114 B2 AU683114 B2 AU 683114B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15901493A | 1993-11-29 | 1993-11-29 | |
| US159014 | 1993-11-29 | ||
| PCT/US1994/012658 WO1995014669A1 (en) | 1993-11-29 | 1994-11-03 | Novel benzenesulfonylimine derivatives as inhibitors of il-1 action |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1087995A AU1087995A (en) | 1995-06-13 |
| AU683114B2 true AU683114B2 (en) | 1997-10-30 |
Family
ID=22570705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU10879/95A Ceased AU683114B2 (en) | 1993-11-29 | 1994-11-03 | Novel benzenesulfonylimine derivatives as inhibitors of IL-1 action |
Country Status (21)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US6562629B1 (en) | 1999-08-11 | 2003-05-13 | Cedars-Sinai Medical Center | Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| DE19705133A1 (de) * | 1997-02-11 | 1998-08-13 | Hoechst Ag | Sulfonamid-substituierte Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EA200000427A1 (ru) * | 1997-10-17 | 2001-02-26 | Авентис Фармасьютикалз Продактс Инк. | Терапевтические применения хинолиновых производных |
| DE19858253A1 (de) * | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| EP1406621A2 (en) * | 2001-06-26 | 2004-04-14 | Beth Israel Deaconess Medical Center | Compositions and methods for inhibiting platelet activation and thrombosis |
| EP2087908B1 (en) | 2001-06-26 | 2018-05-30 | Amgen Inc. | Antibodies to opgl |
| AU2003299971A1 (en) | 2002-12-30 | 2004-07-29 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| KR100687522B1 (ko) * | 2005-05-28 | 2007-02-27 | 한국화학연구원 | 2,2-디메틸-3-에스테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 pge2 활성에 관련된 염증질환 치료제 |
| CN104447489B (zh) * | 2014-12-29 | 2017-01-11 | 南京工业大学 | 3,4-二芳基马来酰亚胺衍生物及其制备方法与应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1086895A (en) * | 1993-11-29 | 1995-06-13 | Merrell Pharmaceuticals Inc. | Heterocyclic benzenesulfonylimine derivatives as inhibitors of il-1 action |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3742951A (en) * | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3921636A (en) * | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
| US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| GB8719102D0 (en) * | 1987-08-12 | 1987-09-16 | Merck Sharp & Dohme | Therapeutic agents |
| AU660969B2 (en) * | 1991-02-27 | 1995-07-13 | Merrell Pharmaceuticals Inc. | NMDA antagonists |
-
1994
- 1994-11-03 CN CN94194304A patent/CN1044116C/zh not_active Expired - Fee Related
- 1994-11-03 DE DE69416859T patent/DE69416859T2/de not_active Expired - Fee Related
- 1994-11-03 KR KR1019960702804A patent/KR100340375B1/ko not_active Expired - Fee Related
- 1994-11-03 CA CA002175458A patent/CA2175458C/en not_active Expired - Fee Related
- 1994-11-03 AT AT95901762T patent/ATE177083T1/de not_active IP Right Cessation
- 1994-11-03 JP JP7515081A patent/JPH09506345A/ja active Pending
- 1994-11-03 DK DK95901762T patent/DK0731791T3/da active
- 1994-11-03 WO PCT/US1994/012658 patent/WO1995014669A1/en active IP Right Grant
- 1994-11-03 NZ NZ276577A patent/NZ276577A/en unknown
- 1994-11-03 HU HU9601435A patent/HU219565B/hu not_active IP Right Cessation
- 1994-11-03 EP EP95901762A patent/EP0731791B1/en not_active Expired - Lifetime
- 1994-11-03 ES ES95901762T patent/ES2131297T3/es not_active Expired - Lifetime
- 1994-11-03 US US08/649,663 patent/US5684017A/en not_active Expired - Fee Related
- 1994-11-03 AU AU10879/95A patent/AU683114B2/en not_active Ceased
- 1994-11-03 PT PT95901762T patent/PT731791E/pt unknown
- 1994-11-23 ZA ZA949303A patent/ZA949303B/xx unknown
- 1994-11-24 TW TW083111032A patent/TW279161B/zh active
- 1994-11-27 IL IL11177694A patent/IL111776A/xx active IP Right Grant
-
1996
- 1996-05-28 FI FI962235A patent/FI109901B/fi not_active IP Right Cessation
- 1996-05-28 NO NO962155A patent/NO306211B1/no unknown
-
1999
- 1999-03-30 GR GR990400918T patent/GR3029827T3/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1086895A (en) * | 1993-11-29 | 1995-06-13 | Merrell Pharmaceuticals Inc. | Heterocyclic benzenesulfonylimine derivatives as inhibitors of il-1 action |
Also Published As
| Publication number | Publication date |
|---|---|
| HU9601435D0 (en) | 1996-07-29 |
| WO1995014669A1 (en) | 1995-06-01 |
| ATE177083T1 (de) | 1999-03-15 |
| AU1087995A (en) | 1995-06-13 |
| HUT76273A (en) | 1997-07-28 |
| FI109901B (fi) | 2002-10-31 |
| DE69416859T2 (de) | 1999-08-05 |
| NO962155D0 (no) | 1996-05-28 |
| ZA949303B (en) | 1995-08-07 |
| EP0731791B1 (en) | 1999-03-03 |
| DK0731791T3 (da) | 1999-09-27 |
| PT731791E (pt) | 2000-11-30 |
| FI962235L (fi) | 1996-05-28 |
| NO306211B1 (no) | 1999-10-04 |
| NZ276577A (en) | 1997-11-24 |
| CN1044116C (zh) | 1999-07-14 |
| KR100340375B1 (ko) | 2002-11-13 |
| NO962155L (no) | 1996-05-28 |
| US5684017A (en) | 1997-11-04 |
| EP0731791A1 (en) | 1996-09-18 |
| HU219565B (hu) | 2001-05-28 |
| ES2131297T3 (es) | 1999-07-16 |
| CA2175458A1 (en) | 1995-06-01 |
| JPH09506345A (ja) | 1997-06-24 |
| IL111776A (en) | 1999-06-20 |
| CA2175458C (en) | 1999-03-02 |
| GR3029827T3 (en) | 1999-06-30 |
| TW279161B (enrdf_load_stackoverflow) | 1996-06-21 |
| DE69416859D1 (de) | 1999-04-08 |
| CN1136311A (zh) | 1996-11-20 |
| IL111776A0 (en) | 1995-01-24 |
| KR960706476A (ko) | 1996-12-09 |
| FI962235A0 (fi) | 1996-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired | ||
| NA | Applications received for extensions of time, section 223 |
Free format text: AN APPLICATION TO EXTEND THE TIME FROM 20011103 TO 20020703 IN WHICH TO PAY A RENEWAL FEE HAS BEEN LODGED |
|
| TH | Corrigenda |
Free format text: IN VOL 16, NO 42, PAGE(S) 7798 UNDER THE HEADING PATENTS CEASED OR EXPIRED, APPLICATIONS LAPSED WITHDRAWN OR REFUSED PLEASE DELETE ALL REFERENCE TO PATENT NUMBER 683114 IN THE NAME OF MERRELL PHARMACEUTICALS INC. |