AU664938B2 - Process for the synthesis of semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3 - Google Patents

Process for the synthesis of semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3 Download PDF

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Publication number
AU664938B2
AU664938B2 AU55084/94A AU5508494A AU664938B2 AU 664938 B2 AU664938 B2 AU 664938B2 AU 55084/94 A AU55084/94 A AU 55084/94A AU 5508494 A AU5508494 A AU 5508494A AU 664938 B2 AU664938 B2 AU 664938B2
Authority
AU
Australia
Prior art keywords
heparin
glycosaminoglycan
acid
aqueous solution
nucleophilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU55084/94A
Other languages
English (en)
Other versions
AU5508494A (en
Inventor
Silvano Piani
Fabrizio Ungarelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Publication of AU5508494A publication Critical patent/AU5508494A/en
Application granted granted Critical
Publication of AU664938B2 publication Critical patent/AU664938B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU55084/94A 1993-03-29 1994-02-10 Process for the synthesis of semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3 Ceased AU664938B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO93A0126 1993-03-29
IT93BO000126A IT1264102B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali

Publications (2)

Publication Number Publication Date
AU5508494A AU5508494A (en) 1994-10-06
AU664938B2 true AU664938B2 (en) 1995-12-07

Family

ID=11338860

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55084/94A Ceased AU664938B2 (en) 1993-03-29 1994-02-10 Process for the synthesis of semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3

Country Status (18)

Country Link
US (1) US5410039A (enExample)
EP (1) EP0618235B1 (enExample)
JP (1) JP2726620B2 (enExample)
KR (1) KR100191885B1 (enExample)
AT (1) ATE155798T1 (enExample)
AU (1) AU664938B2 (enExample)
CA (1) CA2114863C (enExample)
DE (1) DE69404353T2 (enExample)
DK (1) DK0618235T3 (enExample)
ES (1) ES2105382T3 (enExample)
FI (1) FI105100B (enExample)
GR (1) GR3024710T3 (enExample)
IL (1) IL108690A (enExample)
IT (1) IT1264102B1 (enExample)
NO (1) NO305993B1 (enExample)
NZ (1) NZ250816A (enExample)
TW (1) TW266216B (enExample)
ZA (1) ZA94892B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
EP1353556A4 (en) 2001-01-23 2009-09-09 Massachusetts Inst Technology SYNTHESIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS IN SOLID PHASE AND SOLUTION PHASE
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US10913763B2 (en) 2016-03-09 2021-02-09 Glytech, Inc. Method for producing sugar having sulfate group and/or phosphate group

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5504594A (en) * 1993-02-08 1994-08-11 Applied Sorting Technologies Pty Ltd Metal detection in highly mineralised ground
AU658498B2 (en) * 1992-04-17 1995-04-13 Alfa Wassernann S.P.A. Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduronic-2-sulfate acid modified in position 2
AU658499B2 (en) * 1992-04-17 1995-04-13 Alfa Wassernann S.P.A. Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU658498B2 (en) * 1992-04-17 1995-04-13 Alfa Wassernann S.P.A. Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduronic-2-sulfate acid modified in position 2
AU658499B2 (en) * 1992-04-17 1995-04-13 Alfa Wassernann S.P.A. Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3
AU5504594A (en) * 1993-02-08 1994-08-11 Applied Sorting Technologies Pty Ltd Metal detection in highly mineralised ground

Also Published As

Publication number Publication date
ITBO930126A1 (it) 1994-09-29
ATE155798T1 (de) 1997-08-15
DE69404353T2 (de) 1997-11-13
EP0618235B1 (en) 1997-07-23
ES2105382T3 (es) 1997-10-16
FI941432L (fi) 1994-09-30
CA2114863C (en) 1999-07-20
DE69404353D1 (de) 1997-09-04
US5410039A (en) 1995-04-25
FI941432A0 (fi) 1994-03-28
IL108690A (en) 1998-02-22
TW266216B (enExample) 1995-12-21
NO941129D0 (no) 1994-03-28
KR100191885B1 (ko) 1999-06-15
GR3024710T3 (en) 1997-12-31
NZ250816A (en) 1996-02-27
NO305993B1 (no) 1999-08-30
FI105100B (fi) 2000-06-15
NO941129L (no) 1994-09-30
DK0618235T3 (da) 1998-01-26
KR940021583A (ko) 1994-10-19
IL108690A0 (en) 1994-05-30
JPH06322002A (ja) 1994-11-22
CA2114863A1 (en) 1994-09-30
JP2726620B2 (ja) 1998-03-11
ITBO930126A0 (it) 1993-03-29
AU5508494A (en) 1994-10-06
IT1264102B1 (it) 1996-09-10
ZA94892B (en) 1994-08-23
EP0618235A1 (en) 1994-10-05

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Legal Events

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired