AU664021B2 - Solubilization of proteins in active forms - Google Patents

Solubilization of proteins in active forms

Info

Publication number
AU664021B2
AU664021B2 AU84035/91A AU8403591A AU664021B2 AU 664021 B2 AU664021 B2 AU 664021B2 AU 84035/91 A AU84035/91 A AU 84035/91A AU 8403591 A AU8403591 A AU 8403591A AU 664021 B2 AU664021 B2 AU 664021B2
Authority
AU
Australia
Prior art keywords
protein
refolding
agent
approximately
solubilised
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU84035/91A
Other languages
English (en)
Other versions
AU8403591A (en
Inventor
Enzo Crivelli
Nirdosh Kumar Puri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATINCO NV
Original Assignee
Southern Cross Biotech Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Cross Biotech Pty Ltd filed Critical Southern Cross Biotech Pty Ltd
Priority to AU84035/91A priority Critical patent/AU664021B2/en
Publication of AU8403591A publication Critical patent/AU8403591A/en
Assigned to SOUTHERN CROSS BIOTECH PTY LTD. reassignment SOUTHERN CROSS BIOTECH PTY LTD. Alteration of Name(s) of Applicant(s) under S113 Assignors: BUNGE (AUSTRALIA) PTY LTD
Application granted granted Critical
Publication of AU664021B2 publication Critical patent/AU664021B2/en
Assigned to NATINCO NV reassignment NATINCO NV Alteration of Name(s) in Register under S187 Assignors: SOUTHERN CROSS BIOTECH PTY LTD.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU84035/91A 1990-09-05 1991-08-29 Solubilization of proteins in active forms Ceased AU664021B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU84035/91A AU664021B2 (en) 1990-09-05 1991-08-29 Solubilization of proteins in active forms

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPK215990 1990-09-05
AUPK2159 1990-09-05
PCT/AU1991/000395 WO1992004382A1 (en) 1990-09-05 1991-08-29 Solubilization of proteins in active forms
AU84035/91A AU664021B2 (en) 1990-09-05 1991-08-29 Solubilization of proteins in active forms

Publications (2)

Publication Number Publication Date
AU8403591A AU8403591A (en) 1992-03-30
AU664021B2 true AU664021B2 (en) 1995-11-02

Family

ID=3774938

Family Applications (1)

Application Number Title Priority Date Filing Date
AU84035/91A Ceased AU664021B2 (en) 1990-09-05 1991-08-29 Solubilization of proteins in active forms

Country Status (8)

Country Link
EP (1) EP0547102B1 (enExample)
AT (1) ATE168115T1 (enExample)
AU (1) AU664021B2 (enExample)
CA (1) CA2090701C (enExample)
DE (1) DE69129747T2 (enExample)
DK (1) DK0547102T3 (enExample)
ES (1) ES2119779T3 (enExample)
WO (1) WO1992004382A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001453A1 (en) * 1992-07-02 1994-01-20 Pitman-Moore, Inc. A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
DE69432231T2 (de) * 1993-09-22 2004-02-05 Ajinomoto Co., Inc. Peptide mit antithrombotischer aktivität und verfahren zu ihrer herstellung
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
DE10309691B4 (de) * 2003-02-28 2018-10-04 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Gewinnung von löslichen Proteinen aus der Biomasse rekombinanter Mikroorganismen
KR101741859B1 (ko) * 2009-06-22 2017-06-15 암젠 인크 화학적으로 조절된 산화환원 상태를 사용한 단백질의 재폴딩
SI3660032T1 (sl) 2009-06-25 2026-02-27 Amgen Inc. Postopki zajemanja in čiščenja beljakovin, izraženih v nesesalskem sistemu
ES2751735T3 (es) 2013-02-12 2020-04-01 Bristol Myers Squibb Co Métodos de replegado de proteínas a elevado pH
EP2956468B1 (en) 2013-02-12 2020-06-10 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
WO2014155349A2 (en) 2013-03-29 2014-10-02 Dr. Reddy's Laboratories Refolding of proteins
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6701890A (en) * 1989-12-06 1991-06-13 Novartis Ag Process for the production of biologically active protein
AU7413091A (en) * 1990-04-06 1991-11-14 Amgen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
AU636537B2 (en) * 1991-04-26 1993-04-29 Boehringer Mannheim Gmbh Improvement of the yield when disulfide-bonded proteins are secreted

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6079000A (ja) * 1983-10-04 1985-05-04 Takeda Chem Ind Ltd ヒトγ型インタ−フエロン単量体の製造法
DE3587526T3 (de) * 1984-12-06 2002-08-08 Amgen Inc.(N.D.Ges D. Staates Delaware), Thousand Oaks Serinproteaseinhibitoren und isolierungsverfahren dazu.
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
DE3611817A1 (de) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh Verfahren zur renaturierung von proteinen
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
EP0295859B1 (en) * 1987-06-15 1994-11-17 Southern Cross Biotech Pty.Ltd. Production of proteins in active forms
WO1989001046A1 (en) * 1987-07-29 1989-02-09 Schering Biotech Corporation Purification of human interleukin-4 expressed in escherichia coli
CA1340586C (en) * 1988-09-23 1999-06-08 Cetus Corporation Process for recovering microbially produced interferon-beta
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6701890A (en) * 1989-12-06 1991-06-13 Novartis Ag Process for the production of biologically active protein
AU7413091A (en) * 1990-04-06 1991-11-14 Amgen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
AU636537B2 (en) * 1991-04-26 1993-04-29 Boehringer Mannheim Gmbh Improvement of the yield when disulfide-bonded proteins are secreted

Also Published As

Publication number Publication date
CA2090701A1 (en) 1992-03-10
ES2119779T3 (es) 1998-10-16
EP0547102A1 (en) 1993-06-23
EP0547102B1 (en) 1998-07-08
AU8403591A (en) 1992-03-30
DE69129747D1 (de) 1998-08-13
EP0547102A4 (enExample) 1994-04-27
DK0547102T3 (da) 1999-04-19
CA2090701C (en) 2000-05-16
WO1992004382A1 (en) 1992-03-19
ATE168115T1 (de) 1998-07-15
DE69129747T2 (de) 1998-11-12

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: NATINO NV

Free format text: FORMER OWNER WAS: SOUTHERN CROSS BIOTECH PTY. LTD.

TH Corrigenda

Free format text: IN VOL 14, NO 7, PAGE(S) 1249-1250 UNDER THE HEADING ASSIGNMENTS REGISTERED THE NAME OF THE ASSIGNEE IN REGARD TO PATENT NUMBERS 597924, 599922, 612133, 617658, 618396, 647374 AND 664021 SHOULD READ NATINCO NV.