AU6606301A - Pyridine-2-yl-aminoalkyl carbonyl glycyl-beta-alanine and derivatives thereof - Google Patents
Pyridine-2-yl-aminoalkyl carbonyl glycyl-beta-alanine and derivatives thereof Download PDFInfo
- Publication number
- AU6606301A AU6606301A AU66063/01A AU6606301A AU6606301A AU 6606301 A AU6606301 A AU 6606301A AU 66063/01 A AU66063/01 A AU 66063/01A AU 6606301 A AU6606301 A AU 6606301A AU 6606301 A AU6606301 A AU 6606301A
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- Australia
- Prior art keywords
- compounds
- formula
- pyridin
- acid
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000001875 compounds Chemical class 0.000 claims description 112
- -1 pyridin-4-ylphenyl Chemical group 0.000 claims description 72
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 16
- 239000003112 inhibitor Substances 0.000 claims description 15
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- 229940079593 drug Drugs 0.000 claims description 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
- 150000007513 acids Chemical class 0.000 claims description 7
- 125000003277 amino group Chemical group 0.000 claims description 7
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- RMIRJJINXPUIFO-UHFFFAOYSA-N 3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]-3-(4-quinolin-8-ylphenyl)propanoic acid Chemical compound C=1C=C(C=2C3=NC=CC=C3C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 RMIRJJINXPUIFO-UHFFFAOYSA-N 0.000 claims 1
- ZMNBPHYMYZRWLN-UHFFFAOYSA-N 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-quinolin-8-ylphenyl)propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(=CC=2)C=2C3=NC=CC=C3C=CC=2)=C1 ZMNBPHYMYZRWLN-UHFFFAOYSA-N 0.000 claims 1
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- 238000007792 addition Methods 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 6
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- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
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- 229910052731 fluorine Inorganic materials 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 239000012442 inert solvent Substances 0.000 description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10028402A DE10028402A1 (de) | 2000-06-13 | 2000-06-13 | Pyridin-2-yl-aminoalkycarbonylglycyl-beta-alanin und Derivate |
| DE10028402 | 2000-06-13 | ||
| PCT/EP2001/006661 WO2001096365A1 (de) | 2000-06-13 | 2001-06-12 | PYRIDIN-2-YL-AMINOALKYLCARBONYLGLYCYL-β-ALANIN UND DERIVATE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU6606301A true AU6606301A (en) | 2001-12-24 |
Family
ID=7645128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU66063/01A Abandoned AU6606301A (en) | 2000-06-13 | 2001-06-12 | Pyridine-2-yl-aminoalkyl carbonyl glycyl-beta-alanine and derivatives thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20030171304A1 (cs) |
| EP (1) | EP1290010A1 (cs) |
| JP (1) | JP2004503562A (cs) |
| KR (1) | KR20030022145A (cs) |
| CN (1) | CN1436196A (cs) |
| AR (1) | AR028714A1 (cs) |
| AU (1) | AU6606301A (cs) |
| BR (1) | BR0111555A (cs) |
| CA (1) | CA2414000A1 (cs) |
| CZ (1) | CZ20023952A3 (cs) |
| DE (1) | DE10028402A1 (cs) |
| HU (1) | HUP0303716A2 (cs) |
| MX (1) | MXPA02012411A (cs) |
| NO (1) | NO20025968D0 (cs) |
| PL (1) | PL358671A1 (cs) |
| SK (1) | SK17112002A3 (cs) |
| WO (1) | WO2001096365A1 (cs) |
| ZA (1) | ZA200209410B (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455734B1 (en) * | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| EE200100651A (et) | 1999-06-01 | 2003-02-17 | Biogen, Inc. | VLA-1 blokeeriv monoklonaalne antikeha ja tema kasutamine põletiku raviks |
| MXPA03009390A (es) | 2001-04-13 | 2004-01-29 | Biogen Inc | Anticuerpos para integrina vla-1. |
| US7176322B2 (en) | 2002-05-23 | 2007-02-13 | Amgen Inc. | Calcium receptor modulating agents |
| US6908935B2 (en) | 2002-05-23 | 2005-06-21 | Amgen Inc. | Calcium receptor modulating agents |
| MXPA06010756A (es) | 2004-03-24 | 2006-12-15 | Jerini Ag | Nuevos compuestos para la inhibicion de la angiogenesis y su uso. |
| US20090196912A1 (en) * | 2004-07-30 | 2009-08-06 | Gpc Botech Ag | Pyridinylamines |
| PL2034830T3 (pl) | 2006-05-25 | 2015-04-30 | Biogen Ma Inc | Przeciwciało anty-VLA-1 do leczenia udaru |
| WO2010057922A1 (en) * | 2008-11-24 | 2010-05-27 | Basf Se | Curable composition comprising a thermolatent base |
| CN104271122A (zh) | 2012-02-16 | 2015-01-07 | 桑塔鲁斯股份有限公司 | 抗vla1(cd49a)抗体药物组合物 |
| MY208467A (en) * | 2017-11-01 | 2025-05-11 | Arrowhead Pharmaceuticals Inc | Integrin ligands and uses thereof |
| CA3213968A1 (en) | 2021-04-08 | 2022-10-13 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use |
| WO2025152967A1 (zh) * | 2024-01-15 | 2025-07-24 | 武汉人福创新药物研发中心有限公司 | 靶向αvβ6的化合物及其用途 |
| WO2025152969A1 (zh) * | 2024-01-15 | 2025-07-24 | 武汉人福创新药物研发中心有限公司 | 靶向化合物及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024124A1 (en) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
-
2000
- 2000-06-13 DE DE10028402A patent/DE10028402A1/de not_active Withdrawn
-
2001
- 2001-06-12 SK SK1711-2002A patent/SK17112002A3/sk unknown
- 2001-06-12 MX MXPA02012411A patent/MXPA02012411A/es unknown
- 2001-06-12 PL PL01358671A patent/PL358671A1/xx unknown
- 2001-06-12 CZ CZ20023952A patent/CZ20023952A3/cs unknown
- 2001-06-12 KR KR1020027016894A patent/KR20030022145A/ko not_active Withdrawn
- 2001-06-12 EP EP01943499A patent/EP1290010A1/de not_active Withdrawn
- 2001-06-12 BR BR0111555-3A patent/BR0111555A/pt not_active Application Discontinuation
- 2001-06-12 CN CN01811104A patent/CN1436196A/zh active Pending
- 2001-06-12 CA CA002414000A patent/CA2414000A1/en not_active Abandoned
- 2001-06-12 AU AU66063/01A patent/AU6606301A/en not_active Abandoned
- 2001-06-12 WO PCT/EP2001/006661 patent/WO2001096365A1/de not_active Ceased
- 2001-06-12 JP JP2002510506A patent/JP2004503562A/ja active Pending
- 2001-06-12 US US10/297,989 patent/US20030171304A1/en not_active Abandoned
- 2001-06-12 HU HU0303716A patent/HUP0303716A2/hu unknown
- 2001-06-13 AR ARP010102804A patent/AR028714A1/es unknown
-
2002
- 2002-11-19 ZA ZA200209410A patent/ZA200209410B/en unknown
- 2002-12-12 NO NO20025968A patent/NO20025968D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1290010A1 (de) | 2003-03-12 |
| NO20025968L (no) | 2002-12-12 |
| ZA200209410B (en) | 2004-02-19 |
| CZ20023952A3 (cs) | 2003-03-12 |
| DE10028402A1 (de) | 2001-12-20 |
| US20030171304A1 (en) | 2003-09-11 |
| BR0111555A (pt) | 2003-07-08 |
| PL358671A1 (en) | 2004-08-09 |
| CA2414000A1 (en) | 2002-12-03 |
| HUP0303716A2 (hu) | 2004-03-01 |
| KR20030022145A (ko) | 2003-03-15 |
| CN1436196A (zh) | 2003-08-13 |
| WO2001096365A1 (de) | 2001-12-20 |
| NO20025968D0 (no) | 2002-12-12 |
| SK17112002A3 (sk) | 2003-04-01 |
| MXPA02012411A (es) | 2003-04-25 |
| AR028714A1 (es) | 2003-05-21 |
| JP2004503562A (ja) | 2004-02-05 |
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