AU656454B2 - Biphenyl-substituted quinoline derivatives - Google Patents

Biphenyl-substituted quinoline derivatives Download PDF

Info

Publication number
AU656454B2
AU656454B2 AU32991/93A AU3299193A AU656454B2 AU 656454 B2 AU656454 B2 AU 656454B2 AU 32991/93 A AU32991/93 A AU 32991/93A AU 3299193 A AU3299193 A AU 3299193A AU 656454 B2 AU656454 B2 AU 656454B2
Authority
AU
Australia
Prior art keywords
compound
biphenyl
tetrazol
acceptable salt
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU32991/93A
Other languages
English (en)
Other versions
AU3299193A (en
Inventor
John Lloyd
Denis Evan Ryono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of AU3299193A publication Critical patent/AU3299193A/en
Application granted granted Critical
Publication of AU656454B2 publication Critical patent/AU656454B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU32991/93A 1992-02-14 1993-02-12 Biphenyl-substituted quinoline derivatives Ceased AU656454B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83778292A 1992-02-14 1992-02-14
US837782 1992-02-14

Publications (2)

Publication Number Publication Date
AU3299193A AU3299193A (en) 1993-08-19
AU656454B2 true AU656454B2 (en) 1995-02-02

Family

ID=25275409

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32991/93A Ceased AU656454B2 (en) 1992-02-14 1993-02-12 Biphenyl-substituted quinoline derivatives

Country Status (16)

Country Link
EP (1) EP0556060A1 (enExample)
JP (1) JPH05286939A (enExample)
KR (1) KR930017891A (enExample)
CN (1) CN1044243C (enExample)
AU (1) AU656454B2 (enExample)
CA (1) CA2089185A1 (enExample)
FI (1) FI930621A7 (enExample)
HU (1) HU217627B (enExample)
IL (1) IL104623A (enExample)
MX (1) MX9300742A (enExample)
NO (1) NO930520L (enExample)
NZ (1) NZ245757A (enExample)
PL (1) PL172241B1 (enExample)
RU (1) RU2122540C1 (enExample)
TW (1) TW297025B (enExample)
ZA (1) ZA93531B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767129A (en) * 1995-08-24 1998-06-16 Warner-Lambert Company Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
DE60215139T2 (de) 2001-01-26 2007-08-16 Chugai Seiyaku K.K. Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
ATE509014T1 (de) 2001-01-26 2011-05-15 Chugai Pharmaceutical Co Ltd Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
EP1353662B1 (en) 2001-01-26 2007-04-18 Chugai Seiyaku Kabushiki Kaisha Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
JP4155351B2 (ja) 2001-02-20 2008-09-24 中外製薬株式会社 代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤としてのアゾール
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
RU2201753C1 (ru) * 2002-03-12 2003-04-10 Нестерук Владимир Викторович Фармацевтическая композиция, обладающая диуретическим, дегидратирующим и гипотензивным действием
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP4727579B2 (ja) 2003-08-01 2011-07-20 中外製薬株式会社 マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用なシアノアミド化合物
EP1653957B1 (en) 2003-08-01 2008-07-09 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-coa decarboxylase inhibitors
EP2208495B1 (en) 2003-08-01 2011-12-14 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors
DE602004030017D1 (de) 2003-08-01 2010-12-23 Chugai Pharmaceutical Co Ltd Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound
GB0519969D0 (en) * 2005-09-30 2005-11-09 Argenta Discovery Ltd Quinoline compounds
DK1928457T3 (da) 2005-09-30 2013-02-04 Pulmagen Therapeutics Asthma Ltd Quinoliner og deres terapeutiske anvendelse
SI2139881T1 (sl) * 2007-04-04 2012-05-31 Pulmagen Therapeutics Asthma Ltd Kinolini in njihova terapevtska raba

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1189392A (en) * 1991-02-08 1992-09-07 Imperial Chemical Industries Plc Pharmaceutical agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
IE903911A1 (en) * 1989-11-20 1991-05-22 Ici Plc Diazine derivatives
US5049565A (en) * 1990-12-07 1991-09-17 Merck & Co., Inc. Microbial transformation process for preparing anti-hypertensive products
US5157040A (en) * 1991-04-05 1992-10-20 Merck & Co., Inc. Substituted quinolines as angiotensin ii antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1189392A (en) * 1991-02-08 1992-09-07 Imperial Chemical Industries Plc Pharmaceutical agent

Also Published As

Publication number Publication date
ZA93531B (en) 1993-08-26
EP0556060A1 (en) 1993-08-18
NO930520D0 (no) 1993-02-12
PL297713A1 (en) 1993-08-23
NZ245757A (en) 1995-09-26
MX9300742A (es) 1993-09-01
CN1075720A (zh) 1993-09-01
IL104623A0 (en) 1993-06-10
TW297025B (enExample) 1997-02-01
KR930017891A (ko) 1993-09-20
HUT69694A (en) 1995-09-28
CA2089185A1 (en) 1993-08-15
CN1044243C (zh) 1999-07-21
JPH05286939A (ja) 1993-11-02
FI930621A7 (fi) 1993-08-15
FI930621A0 (fi) 1993-02-12
NO930520L (no) 1993-08-16
PL172241B1 (pl) 1997-08-29
IL104623A (en) 1996-12-05
HU217627B (hu) 2000-03-28
AU3299193A (en) 1993-08-19
HU9300386D0 (en) 1993-04-28
RU2122540C1 (ru) 1998-11-27

Similar Documents

Publication Publication Date Title
US5470975A (en) Dihydropyrimidine derivatives
JP3113334B2 (ja) ジヒドロピリミジン誘導体
CA1174682A (en) Active compounds
US5350752A (en) Dihydropyrimidine derivatives
KR900001191B1 (ko) 3-아미노-[1]벤즈아제핀-2-온-1-알카노산의 제조방법
US5246944A (en) Quinoline angiotensin ii antagonists incorporating a substituted benzyl element
NZ245757A (en) Biphenyl-substituted quinoline derivatives and pharmaceutical compositions thereof
AU650294B2 (en) Indole-and benzimidazole-substituted imidazole and benzimidazole derivatives
US5208235A (en) Indole- and benzimidazole-substituted imidazole derivatives
US5212177A (en) Indole and benzimidazole-substituted dihydropyrimidine derivatives
EP0711280A1 (fr) Derives de perhydroisoindole comme antagonistes de la substance p
US5208234A (en) Substituted imidazole phosphonic and phosphinic acid derivatives
HU206118B (en) Process for producing beta-lactam derivatives and pharmaceutical compositions comprising same
US5965730A (en) Pyridine derivatives
KR100540623B1 (ko) 피리도피리미딘 또는 나프틸리딘 유도체
JP2983231B2 (ja) インドロカルバゾル誘導体、その調製方法および薬剤としての使用
US5234923A (en) Substitute indole and benzimidazole derivatives
FI78089B (fi) Foerfarande foer framstaellning av terapeutiskt verkande imidazo/1,5-a/-pyridinderivat.
EP1300403A1 (en) Process for the manufacture of hypoxyxylerone derivatives
US5225408A (en) Biphenyl oxadiazinone angiotensin II inhibitors
US5034531A (en) Fused polycyclic pyranyl compounds as antiviral agents
EP0825190A1 (en) Synthesis of bisindolymaleimides
US6117885A (en) Biphenyl-substituted quinoline derivatives
Hatanaka et al. [3+ 2]-Annulation using allylidene (triphenyl) phosphoranes: a one-step synthesis of cyclopentadienes
US5380719A (en) Quinoxaline biphenyl angiotensin II inhibitors

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired