AU642876B2 - Dihydrospirorenone as an antiandrogen - Google Patents
Dihydrospirorenone as an antiandrogenInfo
- Publication number
- AU642876B2 AU642876B2 AU55094/90A AU5509490A AU642876B2 AU 642876 B2 AU642876 B2 AU 642876B2 AU 55094/90 A AU55094/90 A AU 55094/90A AU 5509490 A AU5509490 A AU 5509490A AU 642876 B2 AU642876 B2 AU 642876B2
- Authority
- AU
- Australia
- Prior art keywords
- dihydrospirorenone
- antiandrogen
- treatment
- premenopause
- oestrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002280 anti-androgenic effect Effects 0.000 title 1
- 239000000051 antiandrogen Substances 0.000 title 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 title 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 title 1
- 229960004845 drospirenone Drugs 0.000 title 1
- 239000003098 androgen Substances 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 230000009245 menopause Effects 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3916112 | 1989-05-16 | ||
| DE3916112A DE3916112A1 (de) | 1989-05-16 | 1989-05-16 | Dihydrospirorenon als antiandrogen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5509490A AU5509490A (en) | 1990-11-22 |
| AU642876B2 true AU642876B2 (en) | 1993-11-04 |
Family
ID=6380839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU55094/90A Expired AU642876B2 (en) | 1989-05-16 | 1990-05-16 | Dihydrospirorenone as an antiandrogen |
Country Status (20)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4321957C2 (de) * | 1993-07-01 | 1995-09-28 | Marika Dr Med Ehrlich | Verwendung eines hormonalen Mittels zur Therapie der Akne |
| DE4344462C2 (de) | 1993-12-22 | 1996-02-01 | Schering Ag | Zusammensetzung für die Empfängnisverhütung |
| DE19651000A1 (de) * | 1996-12-01 | 1998-06-04 | Schering Ag | Oxyiminopregnancarbolactone |
| US6787531B1 (en) | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| EP2305267A3 (en) | 1999-08-31 | 2011-08-17 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive |
| NZ517845A (en) | 1999-08-31 | 2004-12-24 | Schering Ag | Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| JP5350572B2 (ja) * | 2000-12-20 | 2013-11-27 | バイエル ファーマ アクチエンゲゼルシャフト | シクロデキストリン−ドロスピレノン封入複合体 |
| EP1216713A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
| EP1216712A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Cyclodextrin-drospirenone inclusion complexes |
| JP2005522466A (ja) * | 2002-03-18 | 2005-07-28 | ファルマシア・コーポレーション | アルドステロン受容体アンタゴニスト、およびニコチン酸またはニコチン酸誘導体の組合わせ |
| BR0308517A (pt) * | 2002-03-18 | 2005-02-01 | Pharmacia Corp | Combinação de um antagonista do receptor de aldosterona e de um agente sequestrante de ácido biliar |
| WO2004070048A1 (en) * | 2003-02-07 | 2004-08-19 | Pharmacia & Upjohn Company Llc | A microbial process to prepare 5-androsten-3beta, 7alpha, 15alpha-triol-17-one and related analogues |
| ATE429900T1 (de) * | 2004-03-10 | 2009-05-15 | Bayer Schering Pharma Ag | Zusammensetzungen aus drospirenon in molekularer dispersion |
| MY142989A (en) * | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
| US20050220825A1 (en) * | 2004-03-10 | 2005-10-06 | Adrian Funke | Molecular dispersions of drospirenone |
| DE102004026679A1 (de) | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat |
| DE102004026669A1 (de) * | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Verwendung einer Kombination aus Ethinylestradiol und Chlormadinonacetat zur Herstellung eines Arzneimittels |
| DE102004026671A1 (de) * | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Darreichungsform zur hormonalen Kontrazeption |
| DE102004026670A1 (de) | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat |
| ITMI20042338A1 (it) * | 2004-12-06 | 2005-03-06 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| US8475838B2 (en) * | 2005-06-03 | 2013-07-02 | Sandoz Ag | Rapidly-dissolving pharmaceutical composition for inhibiting ovulation |
| ES2311927T5 (es) * | 2005-07-21 | 2014-09-08 | Bayer Pharma Aktiengesellschaft | Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos |
| US7319154B2 (en) | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
| US20070275941A1 (en) * | 2006-05-17 | 2007-11-29 | Vladimir Hanes | Salt sensitivity and prevention of hypertension with drospirenone |
| CN102083418A (zh) * | 2008-04-24 | 2011-06-01 | 伊万斯彻有限公司 | 口服避孕药剂及其制备方法 |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| EP3145489A1 (en) | 2014-05-22 | 2017-03-29 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE3022337A1 (de) * | 1980-06-11 | 1982-01-07 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen |
| US4347245A (en) * | 1981-05-26 | 1982-08-31 | German Shapiro | Spironolactone-containing composition and use thereof |
| JPS59139400A (ja) * | 1983-01-31 | 1984-08-10 | Shionogi & Co Ltd | 抗アルドステロン活性ステロイド誘導体 |
| DE3402329A1 (de) * | 1984-01-20 | 1985-08-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| US4855289A (en) * | 1984-06-04 | 1989-08-08 | Wester Per O | Combination of two active substances |
| US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| DE3615376A1 (de) * | 1986-05-07 | 1987-11-12 | Schering Ag | 2,2;6,6-diethylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DK174724B1 (da) * | 1986-07-15 | 2003-10-06 | Wyeth Corp | Anvendelse af et præparat omfattende et østrogen og et progestogen til fremstilling af en dosisform til tilvejebringelse af hormonerstatningsterapi og kontraception til kvinder i præmenopausen samt pakning til tilvejebringelse af præparatet |
-
1989
- 1989-05-16 DE DE3916112A patent/DE3916112A1/de active Granted
-
1990
- 1990-05-15 IE IE173890A patent/IE81143B1/en not_active IP Right Cessation
- 1990-05-15 CA CA002016780A patent/CA2016780C/en not_active Expired - Lifetime
- 1990-05-15 HU HU903045A patent/HU213408B/hu unknown
- 1990-05-15 DD DD90340683A patent/DD294417A5/de not_active IP Right Cessation
- 1990-05-15 PT PT94038A patent/PT94038B/pt not_active IP Right Cessation
- 1990-05-16 AT AT90250127T patent/ATE154881T1/de active
- 1990-05-16 ES ES90250127T patent/ES2106728T3/es not_active Expired - Lifetime
- 1990-05-16 CN CN90103713A patent/CN1033948C/zh not_active Expired - Lifetime
- 1990-05-16 AU AU55094/90A patent/AU642876B2/en not_active Expired
- 1990-05-16 DE DE59010730T patent/DE59010730D1/de not_active Expired - Lifetime
- 1990-05-16 ZA ZA903754A patent/ZA903754B/xx unknown
- 1990-05-16 EP EP90250127A patent/EP0398460B1/de not_active Expired - Lifetime
- 1990-05-16 JP JP2124308A patent/JP2848919B2/ja not_active Expired - Lifetime
- 1990-05-16 DK DK90250127.9T patent/DK0398460T3/da active
- 1990-05-16 DE DE1990510730 patent/DE122004000006I1/de active Pending
- 1990-05-16 LU LU91065C patent/LU91065I2/fr unknown
- 1990-05-16 IL IL94416A patent/IL94416A/xx not_active IP Right Cessation
-
1993
- 1993-12-07 US US08/162,387 patent/US5569652A/en not_active Expired - Lifetime
-
1997
- 1997-05-14 BR BR1101055-0A patent/BR1101055A/pt active Search and Examination
- 1997-09-24 GR GR970402505T patent/GR3024861T3/el unknown
-
2006
- 2006-02-03 NL NL300221C patent/NL300221I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU642876B2 (en) | Dihydrospirorenone as an antiandrogen | |
| CA2299366A1 (en) | Use of xanthophylls for improvement of duration of muscle function or treatment of muscle disorders or diseases | |
| HUT75103A (en) | Once-day metoprolol oral dosage form and process for it's preparation | |
| PL299814A1 (en) | Pharmaceutical preparation inhibiting depletion of human bone tissue | |
| CA2096350A1 (en) | Treatment for osteoporosis using growth hormone release factor (grf) in combination with parathyroid hormone (pth) | |
| ZA895090B (en) | Novel benzopyran derivatives,processes for their preparation and their use and preparations containing the compounds | |
| DE69710896D1 (en) | Progestogen-anti-progestogen therapien | |
| NZ332105A (en) | Medicaments including human growth hormone for the treatment of type II diabetes and metabolic syndrome | |
| IL120558A0 (en) | New hormonal medicaments and their use for the correction of oestrogenic deficiencies | |
| AU8602391A (en) | Therapeutic device for correcting misalignment of center of gravity of human body | |
| CA2280685A1 (en) | A medicament against infertility and for increasing fertility | |
| AU5702890A (en) | Therapeutic agents of metabolic bone disease | |
| CA2101548A1 (en) | Acylamino-alkylidenhydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases | |
| HUT73500A (en) | Use of benzydamine for producing pharmaceutical compositions for treatment of pathological conditions caused by tnf | |
| EP0408525A3 (en) | Use in therapy of 10-amino-5,6-dihydro-11h-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence | |
| AU1494395A (en) | The use of deoxyspergualin for preparing a pharmaceutical for treating hyperreactive inflammatory diseases | |
| ZA919261B (en) | An imidazobenzodiazepine for the treatment of sleep disorders | |
| AU5003490A (en) | Chin support for use during anaesthesia | |
| GB8600666D0 (en) | Apparatus for surgical & medical uses | |
| AU4252889A (en) | Apparatus for positioning the head of a patient, notably during an ophthalmological examination or treatment | |
| UA10248A (uk) | Спосіб лікування ішемічної хвороби серця на фоні цукрового діабету | |
| GB8805732D0 (en) | Surgical/medical dressing for tube fixation |