AU615244B2 - New derivatives of cysteine, processes for their preparation and their use - Google Patents
New derivatives of cysteine, processes for their preparation and their use Download PDFInfo
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- AU615244B2 AU615244B2 AU27292/88A AU2729288A AU615244B2 AU 615244 B2 AU615244 B2 AU 615244B2 AU 27292/88 A AU27292/88 A AU 27292/88A AU 2729288 A AU2729288 A AU 2729288A AU 615244 B2 AU615244 B2 AU 615244B2
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- 239000002243 precursor Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- TWEGKFXBDXYJIU-UHFFFAOYSA-M sodium;2-methylpropanoate Chemical compound [Na+].CC(C)C([O-])=O TWEGKFXBDXYJIU-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000013417 toxicology model Methods 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8704542 | 1987-11-19 | ||
| SE8704542A SE8704542D0 (sv) | 1987-11-19 | 1987-11-19 | New derivatives of cysteine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2729288A AU2729288A (en) | 1989-06-14 |
| AU615244B2 true AU615244B2 (en) | 1991-09-26 |
Family
ID=20370284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27292/88A Ceased AU615244B2 (en) | 1987-11-19 | 1988-11-16 | New derivatives of cysteine, processes for their preparation and their use |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0317540B1 (en, 2012) |
| JP (1) | JPH02502189A (en, 2012) |
| KR (1) | KR890701553A (en, 2012) |
| CN (1) | CN1033802A (en, 2012) |
| AR (1) | AR245693A1 (en, 2012) |
| AT (1) | ATE79371T1 (en, 2012) |
| AU (1) | AU615244B2 (en, 2012) |
| DD (1) | DD275865A5 (en, 2012) |
| DE (1) | DE3873696T2 (en, 2012) |
| DK (1) | DK347789D0 (en, 2012) |
| EG (1) | EG19066A (en, 2012) |
| ES (1) | ES2051891T3 (en, 2012) |
| FI (1) | FI93442C (en, 2012) |
| GR (1) | GR3006115T3 (en, 2012) |
| HU (1) | HU203224B (en, 2012) |
| IE (1) | IE61181B1 (en, 2012) |
| IL (1) | IL88342A (en, 2012) |
| IS (1) | IS1544B (en, 2012) |
| MY (1) | MY106950A (en, 2012) |
| NO (1) | NO170413C (en, 2012) |
| NZ (1) | NZ226898A (en, 2012) |
| PL (1) | PL158450B1 (en, 2012) |
| PT (1) | PT89035B (en, 2012) |
| SE (1) | SE8704542D0 (en, 2012) |
| WO (1) | WO1989004825A1 (en, 2012) |
| YU (1) | YU46965B (en, 2012) |
| ZA (1) | ZA888509B (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8901570D0 (sv) * | 1989-05-02 | 1989-05-02 | Draco Ab | Organic salts of cysteine derivatives |
| WO1990014335A1 (en) * | 1989-05-17 | 1990-11-29 | Aktiebolaget Astra | Process for the n-monoacylation of cysteine |
| SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
| WO2002013813A1 (en) * | 2000-08-11 | 2002-02-21 | The Lawson Health Research Institute | Compositions and methods for inhibiting islet dysfunction and autoimmune disorders |
| EP4426440A1 (en) * | 2021-11-03 | 2024-09-11 | Lankenau Institute for Medical Research | Compositions and methods for assaying glutathione recylcling capacity |
| US12350250B2 (en) | 2022-04-01 | 2025-07-08 | The Regent Of The University Of Colorado, A Body Corporate | Aggrelytes for treating ocular conditions |
| WO2024243373A1 (en) * | 2023-05-24 | 2024-11-28 | Lento Bio, Inc. | Cysteine derivatives for the treatment of presbyopia |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3091569A (en) * | 1960-08-26 | 1963-05-28 | Mead Johnson & Co | Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus |
| GB954268A (en) * | 1962-02-26 | 1964-04-02 | Mead Johnson & Co | Decongestant compositions comprising n-acylated sulphydryl compounds |
| FR2470M (fr) * | 1962-03-13 | 1964-04-20 | Mead Johnson & Co | Composition thérapeutique. |
| SE312633B (en, 2012) * | 1962-04-26 | 1969-07-21 | Mead Johnson & Co | |
| US3184505A (en) * | 1962-06-18 | 1965-05-18 | Mead Johnson & Co | Process for the n-monoacylation of cysteine |
| US3242052A (en) * | 1963-08-13 | 1966-03-22 | Mead Johnson & Co | Hair treatment with nu-acylcysteines |
| US4093740A (en) * | 1973-02-16 | 1978-06-06 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessier | Fodder for ruminants |
| JPS6011888B2 (ja) * | 1978-10-11 | 1985-03-28 | 参天製薬株式会社 | リウマチ疾患治療薬 |
| IT1141654B (it) * | 1980-01-31 | 1986-10-08 | Alfa Farmaceutici Spa | Nuovi derivati della cisteina ad attivita' antiinfiammatoria,analgesica,antipiretica e mucolitica |
-
1987
- 1987-11-19 SE SE8704542A patent/SE8704542D0/xx unknown
-
1988
- 1988-11-04 MY MYPI88001267A patent/MY106950A/en unknown
- 1988-11-09 YU YU207888A patent/YU46965B/sh unknown
- 1988-11-09 NZ NZ226898A patent/NZ226898A/en unknown
- 1988-11-10 IL IL88342A patent/IL88342A/xx not_active IP Right Cessation
- 1988-11-14 ZA ZA888509A patent/ZA888509B/xx unknown
- 1988-11-15 IE IE341888A patent/IE61181B1/en not_active IP Right Cessation
- 1988-11-16 DE DE8888850393T patent/DE3873696T2/de not_active Expired - Fee Related
- 1988-11-16 EG EG58988A patent/EG19066A/xx active
- 1988-11-16 AT AT88850393T patent/ATE79371T1/de not_active IP Right Cessation
- 1988-11-16 JP JP63509285A patent/JPH02502189A/ja active Pending
- 1988-11-16 EP EP88850393A patent/EP0317540B1/en not_active Expired - Lifetime
- 1988-11-16 ES ES88850393T patent/ES2051891T3/es not_active Expired - Lifetime
- 1988-11-16 AU AU27292/88A patent/AU615244B2/en not_active Ceased
- 1988-11-16 HU HU886768A patent/HU203224B/hu not_active IP Right Cessation
- 1988-11-16 WO PCT/SE1988/000615 patent/WO1989004825A1/en active IP Right Grant
- 1988-11-17 AR AR88312491A patent/AR245693A1/es active
- 1988-11-17 PL PL1988275851A patent/PL158450B1/pl unknown
- 1988-11-17 DD DD88321910A patent/DD275865A5/de not_active IP Right Cessation
- 1988-11-18 IS IS3413A patent/IS1544B/is unknown
- 1988-11-18 PT PT89035A patent/PT89035B/pt not_active IP Right Cessation
- 1988-11-19 CN CN88108035A patent/CN1033802A/zh active Pending
-
1989
- 1989-07-05 NO NO892787A patent/NO170413C/no unknown
- 1989-07-13 DK DK347789A patent/DK347789D0/da not_active Application Discontinuation
- 1989-07-18 FI FI893478A patent/FI93442C/fi not_active IP Right Cessation
- 1989-07-18 KR KR1019890701345A patent/KR890701553A/ko not_active Ceased
-
1992
- 1992-10-29 GR GR920402436T patent/GR3006115T3/el unknown
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