AU569513B2 - 4-substituted amino-3-hydroxy-chroman derivatives - Google Patents

4-substituted amino-3-hydroxy-chroman derivatives

Info

Publication number
AU569513B2
AU569513B2 AU28081/84A AU2808184A AU569513B2 AU 569513 B2 AU569513 B2 AU 569513B2 AU 28081/84 A AU28081/84 A AU 28081/84A AU 2808184 A AU2808184 A AU 2808184A AU 569513 B2 AU569513 B2 AU 569513B2
Authority
AU
Australia
Prior art keywords
compound
formula
group
cyano
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU28081/84A
Other languages
English (en)
Other versions
AU2808184A (en
Inventor
Frederick Cassidy
John Morris Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838313687A external-priority patent/GB8313687D0/en
Priority claimed from GB838334418A external-priority patent/GB8334418D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of AU2808184A publication Critical patent/AU2808184A/en
Application granted granted Critical
Publication of AU569513B2 publication Critical patent/AU569513B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AU28081/84A 1983-05-18 1984-05-16 4-substituted amino-3-hydroxy-chroman derivatives Expired AU569513B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8313687 1983-05-18
GB838313687A GB8313687D0 (en) 1983-05-18 1983-05-18 Active compounds
GB8334418 1983-12-23
GB838334418A GB8334418D0 (en) 1983-12-23 1983-12-23 Active compounds

Publications (2)

Publication Number Publication Date
AU2808184A AU2808184A (en) 1984-11-22
AU569513B2 true AU569513B2 (en) 1988-02-04

Family

ID=26286157

Family Applications (1)

Application Number Title Priority Date Filing Date
AU28081/84A Expired AU569513B2 (en) 1983-05-18 1984-05-16 4-substituted amino-3-hydroxy-chroman derivatives

Country Status (10)

Country Link
US (1) US4571406A (enExample)
EP (1) EP0126311B1 (enExample)
JP (1) JPH0631211B2 (enExample)
AU (1) AU569513B2 (enExample)
CA (1) CA1236458A (enExample)
DE (1) DE3479726D1 (enExample)
ES (1) ES8601180A1 (enExample)
GR (1) GR79976B (enExample)
IE (1) IE57982B1 (enExample)
NZ (1) NZ208169A (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3486354T2 (de) * 1983-05-18 1995-03-30 Beecham Group Plc Chroman- und Chromenderivate.
DE3475786D1 (de) * 1983-09-01 1989-02-02 Beecham Group Plc Chromanol derivatives
DE3477779D1 (en) * 1983-10-13 1989-05-24 Beecham Group Plc Chroman derivatives
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
EP0205292B1 (en) 1985-06-08 1991-11-06 Beecham Group Plc Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
GB8610911D0 (en) * 1986-05-03 1986-06-11 Beecham Group Plc Active compounds
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
CA1308108C (en) * 1987-10-27 1992-09-29 Dominick A. Quagliato Antihypertensive benzopyran derivatives
IL88035A0 (en) * 1987-10-27 1989-06-30 American Home Prod Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
US4992435A (en) * 1988-09-23 1991-02-12 Ortho Pharmaceutical Corporation Substituted thienopyrans as antihypertensive agents
WO1990012010A1 (en) * 1989-04-07 1990-10-18 Pfizer Inc. Substituted chromans in the treatment of asthma, arthritis and related diseases
ES2030627A6 (es) * 1990-11-28 1992-11-01 Uriach & Cia Sa J Procedimiento para la obtencion de compuestos benzopiranicos.
US5624954A (en) * 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
GR1002276B (el) * 1992-10-08 1996-05-02 Smithkline Beecham P.L.C. Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς.
WO1994012173A1 (en) * 1992-11-30 1994-06-09 Smithkline Beecham Plc Benzopyron analogues for the treatment of anxiety, mania, depression or withdrawal symptoms
AP360A (en) * 1992-12-04 1994-09-07 Smithkline Beecham Plc Benzo-and pyridopyran derivatives having anxiolytic and anticonvulsant activity.
US20010021780A1 (en) * 1992-12-11 2001-09-13 Smithkline Beecham P.L.C. Pharmaceutical composition containing bicyclic type compounds
KR100326968B1 (ko) * 1992-12-11 2002-07-27 스미스클라인비이참피이엘시이 약학적 활성을 가진 이환식 화합물
DE69327965T2 (de) * 1992-12-11 2000-10-19 Smithkline Beecham Corp., Philadelphia Pharmazeutische zusammenstellung enthaltende bizyklisch typ verbindungen
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
EP0764159B1 (en) * 1994-06-10 2000-08-09 Smithkline Beecham Plc C -4 amide substituted compounds and their use as therapeutic agents
DE69524871T2 (de) * 1994-06-10 2002-08-22 Smithkline Beecham P.L.C., Brentford Benzopyrans und deren verwendung als therapeutische mittel
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
US5574049A (en) * 1994-07-22 1996-11-12 Sandoz Ltd. 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
CA2589363A1 (en) * 2004-12-13 2006-06-22 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
US20110016548A1 (en) * 2009-07-16 2011-01-20 University Of Southern California Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems
US9499510B2 (en) 2012-07-03 2016-11-22 Proximagen Limited Pro-drug compounds
GB201304814D0 (en) * 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds
CN110183460A (zh) * 2019-04-30 2019-08-30 四川轻化工大学 绵萆薢菲类化合物及应用和提取方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2808084A (en) * 1983-05-18 1984-11-22 Beecham Group Plc 4-substituted amino-3-hydroxy chroman derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1509853A (en) * 1976-01-27 1978-05-04 Beecham Group Ltd 4-amino-3-hydroxy-6-nitrobenzo-pyrans
DE3064286D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0028449B1 (en) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0046652B1 (en) * 1980-08-21 1985-05-22 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
ATE23718T1 (de) * 1981-09-25 1986-12-15 Beecham Group Plc Benzopyran-verbindungen mit pharmazeutischer wirkung.
EP0095316B1 (en) * 1982-05-21 1986-12-03 Beecham Group Plc Pharmaceutically active aminobenzopyrans

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2808084A (en) * 1983-05-18 1984-11-22 Beecham Group Plc 4-substituted amino-3-hydroxy chroman derivatives

Also Published As

Publication number Publication date
ES532582A0 (es) 1985-10-16
DE3479726D1 (de) 1989-10-19
JPS59219278A (ja) 1984-12-10
NZ208169A (en) 1987-08-31
JPH0631211B2 (ja) 1994-04-27
EP0126311B1 (en) 1989-09-13
EP0126311A2 (en) 1984-11-28
AU2808184A (en) 1984-11-22
ES8601180A1 (es) 1985-10-16
CA1236458A (en) 1988-05-10
EP0126311A3 (en) 1987-05-27
US4571406A (en) 1986-02-18
IE841229L (en) 1984-11-18
IE57982B1 (en) 1993-06-02
GR79976B (enExample) 1984-10-31

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