AU558450B2 - 3-substituted-b-carbolines - Google Patents

3-substituted-b-carbolines

Info

Publication number
AU558450B2
AU558450B2 AU78592/81A AU7859281A AU558450B2 AU 558450 B2 AU558450 B2 AU 558450B2 AU 78592/81 A AU78592/81 A AU 78592/81A AU 7859281 A AU7859281 A AU 7859281A AU 558450 B2 AU558450 B2 AU 558450B2
Authority
AU
Australia
Prior art keywords
atoms
hydrogen
lower alkyl
alkyl
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU78592/81A
Other languages
English (en)
Other versions
AU7859281A (en
Inventor
Claus Thyco Dr Braestrup
Joergen Anders Christensen
Ulrich Eder
Mogens Engelstoft
Andreas Huth
Wolfgang Kehr
Gunter Neef
Dieter Palenschat
Dieter Rahtz
Ralph Schmiechen
Dieter Seidelmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803048318 external-priority patent/DE3048318A1/de
Priority claimed from DE19813136857 external-priority patent/DE3136857A1/de
Application filed by Schering AG filed Critical Schering AG
Publication of AU7859281A publication Critical patent/AU7859281A/en
Application granted granted Critical
Publication of AU558450B2 publication Critical patent/AU558450B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU78592/81A 1980-12-17 1981-12-17 3-substituted-b-carbolines Ceased AU558450B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19803048318 DE3048318A1 (de) 1980-12-17 1980-12-17 4-alkoxyalkyl substituierte (beta)-carbolin-3-carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE30483182 1980-12-17
DK913/81 1981-02-27
DK91381 1981-02-27
DE19813136857 DE3136857A1 (de) 1981-09-14 1981-09-14 Substituierte (beta)-carbolin-3-carbonsaeurealkylester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE31368573 1981-09-14

Publications (2)

Publication Number Publication Date
AU7859281A AU7859281A (en) 1982-06-24
AU558450B2 true AU558450B2 (en) 1987-01-29

Family

ID=27189019

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78592/81A Ceased AU558450B2 (en) 1980-12-17 1981-12-17 3-substituted-b-carbolines

Country Status (16)

Country Link
US (2) US4435403A (OSRAM)
EP (1) EP0054507B1 (OSRAM)
JP (1) JPS57123180A (OSRAM)
AT (1) ATE32513T1 (OSRAM)
AU (1) AU558450B2 (OSRAM)
CA (1) CA1188300A (OSRAM)
DD (1) DD161210A5 (OSRAM)
DE (1) DE3176650D1 (OSRAM)
EG (1) EG17159A (OSRAM)
ES (1) ES8301984A1 (OSRAM)
HU (1) HU187395B (OSRAM)
IE (1) IE53931B1 (OSRAM)
IL (1) IL64560A (OSRAM)
NZ (1) NZ199312A (OSRAM)
PT (1) PT74143B (OSRAM)
RO (1) RO82164A (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU581435B2 (en) * 1984-05-15 1989-02-23 Schering Aktiengesellschaft ``-carboline-3-carboxylic acid derivatives, method of preparing the same and their use

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
DE3240514A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
DE3246932A1 (de) * 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
DK149270C (da) * 1983-05-27 1986-08-25 Schering Ag Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DE3322894A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
US4631149A (en) * 1983-07-25 1986-12-23 University Of Illinois Antiviral eudistomins from a marine tunicate
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1252462A (en) * 1984-01-19 1989-04-11 Walter Hunkeler Imidazodiazepine derivatives
DK240084D0 (da) * 1984-05-15 1984-05-15 Ferrosan As New beta-carboline-3-oxadiazolyl derivatives
GB8432073D0 (en) * 1984-12-19 1985-01-30 Roussel Lab Ltd Chemical compounds
DE3504045A1 (de) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinen durch dehydrierung
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3540653A1 (de) * 1985-11-13 1987-05-14 Schering Ag Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3540654A1 (de) * 1985-11-13 1987-05-14 Schering Ag Phenoxy-substituierte ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3545776A1 (de) * 1985-12-20 1987-06-25 Schering Ag 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4952584A (en) * 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
DE3609699A1 (de) * 1986-03-20 1987-09-24 Schering Ag 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester
DE3608089A1 (de) * 1986-03-08 1987-09-10 Schering Ag Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
EP0304223A3 (en) * 1987-08-17 1990-10-24 Merck & Co. Inc. Beta-carbolines as cholecy-stokinin and gastrin antagonist
IL87563A (en) * 1987-08-28 1993-08-18 Schering Ag Isoxazole-b-carboline derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE3729370C2 (de) * 1987-08-31 1995-04-20 Schering Ag Verfahren zur Herstellung von 4-Alkoxyalkyl-beta-carbolinen
DE3943225A1 (de) * 1989-12-23 1991-06-27 Schering Ag Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln
DE4013907A1 (de) * 1990-04-26 1991-10-31 Schering Ag Verfahren zur herstellung von gramin-derivaten
DE4029389A1 (de) * 1990-09-13 1992-03-26 Schering Ag Verfahren zur herstellung von (beta)-carbolin-derivaten
US5350750A (en) * 1991-04-27 1994-09-27 Schering Aktiengesellschaft β-carboline-3-hydroxyalkylcarboxylic acid ester derivatives, process for their production and their use in pharmaceutical agents
DE4120109A1 (de) * 1991-06-15 1992-12-17 Schering Ag 3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln
US5543519A (en) * 1991-06-15 1996-08-06 Schering Aktiengesellschaft 3-aryl or 3-hetaryl-β-carbolines, their production and use in pharmaceutical agents
DE4122722A1 (de) * 1991-07-06 1993-01-07 Schering Ag Verfahren zur herstellung von indol-derivaten
DE4130933A1 (de) * 1991-09-13 1993-03-18 Schering Ag Neue (beta)-carbolinderivate, deren herstellung und verwendung in arzneimitteln
US5585490A (en) * 1991-10-08 1996-12-17 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands
US5367077A (en) * 1992-04-08 1994-11-22 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
AU4117493A (en) * 1992-04-08 1994-11-21 Neurogen Corporation Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands
US5286860A (en) * 1992-11-12 1994-02-15 Neurogen Corporation Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
DE4330175A1 (de) * 1993-08-31 1995-03-02 Schering Ag Alkoxy-substituierte beta-Carboline
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US6211365B1 (en) 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
EP0888300A1 (en) 1996-03-22 1999-01-07 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
PL354513A1 (en) 1999-08-31 2004-01-26 Neurogen Corporation Fused pyrrolecarboxamides: gaba brain receptor ligands
US20040253891A1 (en) * 2000-09-12 2004-12-16 Schierenbeck Alan W. Composite structure for protective garment
US20050101623A1 (en) * 2003-07-23 2005-05-12 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
FR2953838B1 (fr) * 2009-12-10 2012-02-24 Sanofi Aventis Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
FR2953837B1 (fr) * 2009-12-10 2012-03-09 Sanofi Aventis Derives 9h-pyridino[3,4-b]indole disubstitues, leur preparation et leur utilisation therapeutique
US11485734B2 (en) 2018-10-02 2022-11-01 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA786351A (en) 1968-05-28 Leonard Frederick PROCESS FOR THE PREPARATION OF NEW .beta.-CARBOLIN-CARBOXYLIC ACID AMIDE DERIVATIVES
FR894620A (fr) 1943-02-08 1944-12-29 Barrere & Cie M Embrayeur-inverseur pour la commande des arbres porte-hélice des bateaux
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
FR2306693A1 (fr) * 1975-04-11 1976-11-05 Roussel Uclaf Nouveaux derives du /9h/pyrido/3,4-b/ indole et leurs sels, procede de preparation et application a titre de medicaments
FR2455044A1 (fr) * 1979-04-26 1980-11-21 Synthelabo Pyrido-indoles et leur application en therapeutique
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS574987A (en) * 1980-06-09 1982-01-11 Sankyo Co Ltd Pyridoindolecarboxylic acid derivative and its preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU581435B2 (en) * 1984-05-15 1989-02-23 Schering Aktiengesellschaft ``-carboline-3-carboxylic acid derivatives, method of preparing the same and their use

Also Published As

Publication number Publication date
EP0054507A3 (en) 1982-09-15
IE53931B1 (en) 1989-04-26
ES508073A0 (es) 1983-02-01
IL64560A0 (en) 1982-03-31
IL64560A (en) 1988-05-31
US4435403A (en) 1984-03-06
ATE32513T1 (de) 1988-03-15
NZ199312A (en) 1989-08-29
EG17159A (en) 1990-12-30
AU7859281A (en) 1982-06-24
PT74143A (de) 1982-01-01
PT74143B (de) 1983-05-16
RO82164B (ro) 1983-06-30
DE3176650D1 (en) 1988-03-24
CA1188300A (en) 1985-06-04
US4596808A (en) 1986-06-24
EP0054507B1 (en) 1988-02-17
ES8301984A1 (es) 1983-02-01
HU187395B (en) 1985-12-28
IE812954L (en) 1982-06-17
RO82164A (ro) 1983-07-07
JPS57123180A (en) 1982-07-31
EP0054507A2 (en) 1982-06-23
DD161210A5 (de) 1985-06-12
JPH0557274B2 (OSRAM) 1993-08-23

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