AU555821B2 - Hydroxy-2-benzothiazolesulphonamides for high intra- ocular pressure - Google Patents

Hydroxy-2-benzothiazolesulphonamides for high intra- ocular pressure

Info

Publication number
AU555821B2
AU555821B2 AU90048/82A AU9004882A AU555821B2 AU 555821 B2 AU555821 B2 AU 555821B2 AU 90048/82 A AU90048/82 A AU 90048/82A AU 9004882 A AU9004882 A AU 9004882A AU 555821 B2 AU555821 B2 AU 555821B2
Authority
AU
Australia
Prior art keywords
hydroxy
benzothiazolesulphonamides
ocular pressure
high intra
intra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU90048/82A
Other languages
English (en)
Other versions
AU9004882A (en
Inventor
Stuart R. Michelson
Harvey Schwam
John M. Sondey
Otto W. Woltersdorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU9004882A publication Critical patent/AU9004882A/en
Application granted granted Critical
Publication of AU555821B2 publication Critical patent/AU555821B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/76—Sulfur atoms attached to a second hetero atom
    • C07D277/80—Sulfur atoms attached to a second hetero atom to a nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU90048/82A 1981-11-03 1982-11-01 Hydroxy-2-benzothiazolesulphonamides for high intra- ocular pressure Ceased AU555821B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/317,807 US4386098A (en) 1981-11-03 1981-11-03 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US317807 2002-12-12

Publications (2)

Publication Number Publication Date
AU9004882A AU9004882A (en) 1983-05-12
AU555821B2 true AU555821B2 (en) 1986-10-09

Family

ID=23235348

Family Applications (1)

Application Number Title Priority Date Filing Date
AU90048/82A Ceased AU555821B2 (en) 1981-11-03 1982-11-01 Hydroxy-2-benzothiazolesulphonamides for high intra- ocular pressure

Country Status (16)

Country Link
US (1) US4386098A (OSRAM)
EP (1) EP0079269B1 (OSRAM)
JP (1) JPS5885877A (OSRAM)
AT (1) ATE19733T1 (OSRAM)
AU (1) AU555821B2 (OSRAM)
CA (1) CA1184119A (OSRAM)
DE (1) DE3271190D1 (OSRAM)
DK (1) DK486282A (OSRAM)
FI (1) FI823720L (OSRAM)
GR (1) GR77056B (OSRAM)
IE (1) IE54217B1 (OSRAM)
IL (1) IL67073A0 (OSRAM)
NO (1) NO823638L (OSRAM)
NZ (1) NZ202292A (OSRAM)
PT (1) PT75777B (OSRAM)
ZA (1) ZA828003B (OSRAM)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2155331B (en) * 1980-07-09 1988-09-01 Florida University Of Composition for reducing intraocular pressure
US4619939A (en) * 1980-07-09 1986-10-28 University Of Florida Process for reducing intraocular pressure
US4746745A (en) * 1980-07-09 1988-05-24 Maren Thomas H 1,3,4-thiadiazoline-5-sulfonamides
US4454148A (en) * 1982-09-02 1984-06-12 Merck & Co., Inc. 5-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4975449A (en) * 1983-02-04 1990-12-04 University Of Iowa Research Foundation Topical treatment of glaucoma with 2-benzothiazolesulfonamide derivative
US4483864A (en) * 1983-02-04 1984-11-20 University Of Iowa Research Foundation Non-classical topical treatment for glaucoma
US5095026A (en) * 1983-02-04 1992-03-10 University Of Iowa Research Foundation Prodrugs of carbonic anhydrase inhibitors
US4500538A (en) * 1983-03-14 1985-02-19 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4456599A (en) * 1983-04-22 1984-06-26 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4542152A (en) * 1983-05-23 1985-09-17 Merck & Co., Inc. 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4510155A (en) * 1983-06-02 1985-04-09 Merck & Co., Inc. 6(or 5)-Hydroxybenzothiazole-2-sulfonamide-O-sulfate salts for the topical treatment of elevated intraocular pressure
US4585787A (en) * 1983-06-20 1986-04-29 Merck & Co., Inc. 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
NZ208444A (en) * 1983-06-20 1987-08-31 Merck & Co Inc 2-thiophene derivatives and pharmaceutical compositions
ES8600752A1 (es) * 1983-06-20 1985-10-16 Merck & Co Inc Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida.
US4486444A (en) * 1983-06-20 1984-12-04 Merck & Co., Inc. (Hydroxybenzoyl)thiophenesulfonamide and acyl derivatives thereof for the topical treatment of elevated intraocular pressure
US4788192A (en) * 1983-06-20 1988-11-29 Merck & Co., Inc. 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
US4622403A (en) * 1983-10-11 1986-11-11 Merck Frosst Canada, Inc. 6-H dibenz[b,f]thiepin compounds
US4505923A (en) * 1983-10-31 1985-03-19 Merck & Co., Inc. Ethers of hydroxybenzothiazole-2-sulfonamide for the topical treatment of elevated intraocular pressure
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4544667A (en) * 1984-02-09 1985-10-01 Merck & Co., Inc. 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure
DE3576498D1 (de) * 1984-03-14 1990-04-19 Merck & Co Inc 2-sulfamoyl-1h-indole-derivate zur behandlung von hohem intraocularem druck.
US4840963A (en) * 1984-03-14 1989-06-20 Merck & Co., Inc. 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure
IT1176613B (it) * 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
DE3568431D1 (en) * 1984-12-12 1989-04-06 Merck & Co Inc Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4929637A (en) * 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4914111A (en) * 1987-03-23 1990-04-03 Merck & Co., Inc. 4-Benzylthiophene (or furan)-2-sulfonamides as antiglaucoma agents
US4847289A (en) * 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US4929549A (en) * 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
US5059613A (en) * 1990-03-19 1991-10-22 Research Corporation Technologies, Inc. Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
US5216020A (en) * 1990-10-12 1993-06-01 Merck & Co., Inc. Substituted 4,5-dihydrothieno(2,3-b)thiophene-2-sulfonamides and 6,6-dioxides thereof
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
US5300499A (en) * 1992-09-02 1994-04-05 Allergan, Inc. 5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US5519040A (en) * 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5698533A (en) * 1994-07-26 1997-12-16 Kang; Meng-Che Ophthalmic pharmaceutical composition
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5789435A (en) * 1995-05-22 1998-08-04 Advanced Research And Technology Institute Method to increase retinal and optical nerve head blood flow velocity in order to preserve sight
US6156785A (en) * 1998-01-23 2000-12-05 Merck Sharp & Dohme B.V. Method for increasing oxygen tension in the optic nerve and retina
US6545036B2 (en) 2000-01-18 2003-04-08 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US6548535B2 (en) 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
CA2419158A1 (en) * 2000-08-11 2002-02-21 Einar Stefansson Method for the prevention and treatment of retinopathy
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
US20050124595A1 (en) * 2002-03-15 2005-06-09 Goetz Michael A. Compositions and methods for treating glaucoma and ocular hypertension
EP1513523A1 (en) * 2002-06-06 2005-03-16 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
JP2005532363A (ja) * 2002-06-14 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧を治療するための眼用組成物
JP2005533055A (ja) * 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド 新規マキシｋチャンネルブロッカー、その使用方法および製造方法
CA2488884A1 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
WO2003105781A2 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
WO2004019938A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
WO2004037786A2 (en) * 2002-10-25 2004-05-06 Merck Frosst Canada & Co. 2-pyrrolidones as ep4 receptor agonists
CA2519899A1 (en) * 2003-03-27 2004-10-14 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
ATE535243T1 (de) * 2007-05-11 2011-12-15 Santen Pharmaceutical Co Ltd Prophylaktisches oder therapeutisches mittel für posteriore augenerkrankung mit selektivem nicht- ergot-d2-rezeptoragonist als wirkstoff
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2595334A (en) * 1950-04-08 1952-05-06 American Cyanamid Co Benzothiazolesulfonamides and method of preparing the same
US3519630A (en) * 1969-02-06 1970-07-07 Pennsalt Chemicals Corp Antibacterial and antifungal treatment with sulfones
ATE9059T1 (de) * 1980-01-28 1984-09-15 Merck & Co. Inc. Ophthalmische kohlensaure anhydrase-inhibitoren enthaltende einlagen zur verringerung intraokularer hypertension.

Also Published As

Publication number Publication date
DE3271190D1 (en) 1986-06-19
GR77056B (OSRAM) 1984-09-05
PT75777A (en) 1982-12-01
FI823720A0 (fi) 1982-11-01
FI823720A7 (fi) 1983-05-04
NO823638L (no) 1983-05-04
JPS5885877A (ja) 1983-05-23
ATE19733T1 (de) 1986-05-15
EP0079269B1 (en) 1986-05-14
AU9004882A (en) 1983-05-12
ZA828003B (en) 1984-07-25
EP0079269A1 (en) 1983-05-18
FI823720L (fi) 1983-05-04
PT75777B (en) 1986-01-15
CA1184119A (en) 1985-03-19
US4386098A (en) 1983-05-31
NZ202292A (en) 1986-01-24
IL67073A0 (en) 1983-02-23
IE54217B1 (en) 1989-07-19
DK486282A (da) 1983-05-04
IE822618L (en) 1983-05-03

Similar Documents

Publication Publication Date Title
AU555821B2 (en) Hydroxy-2-benzothiazolesulphonamides for high intra- ocular pressure
AU560189B2 (en) Treatment of ocular hypertension and glaucoma
DE3364150D1 (en) Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
GB8300499D0 (en) Fragmentation of ocular tissues
IL96242A0 (en) Device and method for relieving intraocular pressure
LU90935I2 (en) Azopt-brinzolamide
AU7853287A (en) Method and artificial intraocular lens device for the phakic treatment of myopia
FR2648702B1 (OSRAM)
EP0128784A3 (en) Posterior chamber ocular implant
AU7317387A (en) Use of tetrahydrocortisol in glaucoma therapy
AU563650B2 (en) Pharmaceutical compositions of benzothiophene derivatives
AU551900B2 (en) Anthralin compositions for treatment of skin diseases
HU885915D0 (en) Process for the production of medical preparations for reducing intraocular pressure
AR241136A1 (es) Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada"
DE3064137D1 (en) Ophthalmic solution for intraocular pressure adjustment
EP0122831A3 (en) Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure
DE3273950D1 (en) Use of 1-(p-isopropoxyethoxymethyl-phenoxy)-3-isopropylaminopropan-2-ol for the preparation of a medicament for the reduction of internal pressure in the eye
EP0122178A3 (en) Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
ZA842959B (en) Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
HUT42932A (en) Process for production of compositions against glaucoma
AU1966988A (en) Ophthalmic agent and related compositions and method for treatment of the cornea
ZA848451B (en) Ethers of hydroxybenzothiazole-2-sulfonamide for the topical treatment of elevated intraocular pressure
ZA842665B (en) Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
EP0155214A3 (en) 2-sulfamoyl-1h-indole derivatives for the treatment of elevated intraocular pressure
ZA842958B (en) Benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure