FI823720L - Hydroxisubstituerad 2-bensotiazolsulfonamid foer lokalbehandling av oekat tryck i oegat - Google Patents

Hydroxisubstituerad 2-bensotiazolsulfonamid foer lokalbehandling av oekat tryck i oegat

Info

Publication number
FI823720L
FI823720L FI823720A FI823720A FI823720L FI 823720 L FI823720 L FI 823720L FI 823720 A FI823720 A FI 823720A FI 823720 A FI823720 A FI 823720A FI 823720 L FI823720 L FI 823720L
Authority
FI
Finland
Prior art keywords
oekat
oegat
benzotiazolesulphonamid
tryck
hydroxic
Prior art date
Application number
FI823720A
Other languages
English (en)
Other versions
FI823720A0 (fi
Inventor
Otto Woltersdorf Jr
Harvey Schwamm
Stuart Michelson
John Sondey
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI823720A0 publication Critical patent/FI823720A0/fi
Publication of FI823720L publication Critical patent/FI823720L/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/76—Sulfur atoms attached to a second hetero atom
    • C07D277/80—Sulfur atoms attached to a second hetero atom to a nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI823720A 1981-11-03 1982-11-01 Hydroxisubstituerad 2-bensotiazolsulfonamid foer lokalbehandling av oekat tryck i oegat FI823720L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/317,807 US4386098A (en) 1981-11-03 1981-11-03 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure

Publications (2)

Publication Number Publication Date
FI823720A0 FI823720A0 (fi) 1982-11-01
FI823720L true FI823720L (fi) 1983-05-04

Family

ID=23235348

Family Applications (1)

Application Number Title Priority Date Filing Date
FI823720A FI823720L (fi) 1981-11-03 1982-11-01 Hydroxisubstituerad 2-bensotiazolsulfonamid foer lokalbehandling av oekat tryck i oegat

Country Status (16)

Country Link
US (1) US4386098A (fi)
EP (1) EP0079269B1 (fi)
JP (1) JPS5885877A (fi)
AT (1) ATE19733T1 (fi)
AU (1) AU555821B2 (fi)
CA (1) CA1184119A (fi)
DE (1) DE3271190D1 (fi)
DK (1) DK486282A (fi)
FI (1) FI823720L (fi)
GR (1) GR77056B (fi)
IE (1) IE54217B1 (fi)
IL (1) IL67073A0 (fi)
NO (1) NO823638L (fi)
NZ (1) NZ202292A (fi)
PT (1) PT75777B (fi)
ZA (1) ZA828003B (fi)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2155331B (en) * 1980-07-09 1988-09-01 Florida University Of Composition for reducing intraocular pressure
US4746745A (en) * 1980-07-09 1988-05-24 Maren Thomas H 1,3,4-thiadiazoline-5-sulfonamides
US4619939A (en) * 1980-07-09 1986-10-28 University Of Florida Process for reducing intraocular pressure
US4454148A (en) * 1982-09-02 1984-06-12 Merck & Co., Inc. 5-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4483864A (en) * 1983-02-04 1984-11-20 University Of Iowa Research Foundation Non-classical topical treatment for glaucoma
US5095026A (en) * 1983-02-04 1992-03-10 University Of Iowa Research Foundation Prodrugs of carbonic anhydrase inhibitors
US4975449A (en) * 1983-02-04 1990-12-04 University Of Iowa Research Foundation Topical treatment of glaucoma with 2-benzothiazolesulfonamide derivative
US4500538A (en) * 1983-03-14 1985-02-19 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4456599A (en) * 1983-04-22 1984-06-26 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4542152A (en) * 1983-05-23 1985-09-17 Merck & Co., Inc. 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4510155A (en) * 1983-06-02 1985-04-09 Merck & Co., Inc. 6(or 5)-Hydroxybenzothiazole-2-sulfonamide-O-sulfate salts for the topical treatment of elevated intraocular pressure
US4585787A (en) * 1983-06-20 1986-04-29 Merck & Co., Inc. 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4788192A (en) * 1983-06-20 1988-11-29 Merck & Co., Inc. 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
NZ208444A (en) * 1983-06-20 1987-08-31 Merck & Co Inc 2-thiophene derivatives and pharmaceutical compositions
US4486444A (en) * 1983-06-20 1984-12-04 Merck & Co., Inc. (Hydroxybenzoyl)thiophenesulfonamide and acyl derivatives thereof for the topical treatment of elevated intraocular pressure
ES8600752A1 (es) * 1983-06-20 1985-10-16 Merck & Co Inc Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida.
US4622403A (en) * 1983-10-11 1986-11-11 Merck Frosst Canada, Inc. 6-H dibenz[b,f]thiepin compounds
US4505923A (en) * 1983-10-31 1985-03-19 Merck & Co., Inc. Ethers of hydroxybenzothiazole-2-sulfonamide for the topical treatment of elevated intraocular pressure
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4544667A (en) * 1984-02-09 1985-10-01 Merck & Co., Inc. 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure
US4840963A (en) * 1984-03-14 1989-06-20 Merck & Co., Inc. 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure
EP0155214B1 (en) * 1984-03-14 1990-03-14 Merck & Co. Inc. 2-sulfamoyl-1h-indole derivatives for the treatment of elevated intraocular pressure
IT1176613B (it) * 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
EP0189690B1 (en) * 1984-12-12 1989-03-01 Merck & Co. Inc. Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4929637A (en) * 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4914111A (en) * 1987-03-23 1990-04-03 Merck & Co., Inc. 4-Benzylthiophene (or furan)-2-sulfonamides as antiglaucoma agents
US4847289A (en) * 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US4929549A (en) * 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
US5059613A (en) * 1990-03-19 1991-10-22 Research Corporation Technologies, Inc. Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
US5216020A (en) * 1990-10-12 1993-06-01 Merck & Co., Inc. Substituted 4,5-dihydrothieno(2,3-b)thiophene-2-sulfonamides and 6,6-dioxides thereof
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
US5300499A (en) * 1992-09-02 1994-04-05 Allergan, Inc. 5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US5519040A (en) * 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5698533A (en) * 1994-07-26 1997-12-16 Kang; Meng-Che Ophthalmic pharmaceutical composition
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5789435A (en) * 1995-05-22 1998-08-04 Advanced Research And Technology Institute Method to increase retinal and optical nerve head blood flow velocity in order to preserve sight
US6156785A (en) * 1998-01-23 2000-12-05 Merck Sharp & Dohme B.V. Method for increasing oxygen tension in the optic nerve and retina
US6548535B2 (en) 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
CA2396319A1 (en) 2000-01-18 2001-07-26 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
WO2002013800A2 (en) * 2000-08-11 2002-02-21 Einar Stefansson Method for the prevention and treatment of retinopathy
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
US20050124595A1 (en) * 2002-03-15 2005-06-09 Goetz Michael A. Compositions and methods for treating glaucoma and ocular hypertension
WO2003103664A1 (en) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
EP1515721A4 (en) * 2002-06-14 2006-07-26 Merck & Co Inc OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION
EP1515974A4 (en) * 2002-06-17 2007-02-28 Merck & Co Inc NOVEL MAXI K CHANNEL BLOCKERS, METHODS OF USE, AND METHODS OF MANUFACTURING THE SAME
US7279490B2 (en) * 2002-06-17 2007-10-09 Merck & Co, Inc. Ophthalmic compositions for treating ocular hypertension
EP1515730A4 (en) * 2002-06-17 2005-07-20 Merck & Co Inc NEW MAXI K CHANNEL INHIBITORS, METHODS OF USE, AND METHOD OF MANUFACTURING THE SAME
CA2495917A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
CA2502914A1 (en) * 2002-10-25 2004-05-06 Merck Frosst Canada & Co. 2-pyrrolidones as ep4 receptor agonists
EP1610776A4 (en) * 2003-03-27 2007-03-28 Merck & Co Inc OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA
JP2008308489A (ja) * 2007-05-11 2008-12-25 Santen Pharmaceut Co Ltd ロピニロール又はその塩を有効成分として含有する後眼部疾患の予防又は治療剤
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2595334A (en) * 1950-04-08 1952-05-06 American Cyanamid Co Benzothiazolesulfonamides and method of preparing the same
US3519630A (en) * 1969-02-06 1970-07-07 Pennsalt Chemicals Corp Antibacterial and antifungal treatment with sulfones
ATE9059T1 (de) * 1980-01-28 1984-09-15 Merck & Co. Inc. Ophthalmische kohlensaure anhydrase-inhibitoren enthaltende einlagen zur verringerung intraokularer hypertension.

Also Published As

Publication number Publication date
IE822618L (en) 1983-05-03
ATE19733T1 (de) 1986-05-15
ZA828003B (en) 1984-07-25
DK486282A (da) 1983-05-04
NZ202292A (en) 1986-01-24
US4386098A (en) 1983-05-31
JPS5885877A (ja) 1983-05-23
FI823720A0 (fi) 1982-11-01
AU555821B2 (en) 1986-10-09
EP0079269A1 (en) 1983-05-18
PT75777B (en) 1986-01-15
AU9004882A (en) 1983-05-12
IE54217B1 (en) 1989-07-19
DE3271190D1 (en) 1986-06-19
CA1184119A (en) 1985-03-19
IL67073A0 (en) 1983-02-23
EP0079269B1 (en) 1986-05-14
GR77056B (fi) 1984-09-05
NO823638L (no) 1983-05-04
PT75777A (en) 1982-12-01

Similar Documents

Publication Publication Date Title
FI823720L (fi) Hydroxisubstituerad 2-bensotiazolsulfonamid foer lokalbehandling av oekat tryck i oegat
DE3364150D1 (en) Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
NO831084L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kvartaere dibenzotiepin-n-alkyl-norskopinetere
ATE76294T1 (de) Galanthamin oder dessen analoge zur behandlung der alzheimerschen krankheit.
NO820263L (no) Fremgangsmaate ved fremstilling av heterocycliske estere av steroider
NL7900676A (nl) Werkwijze voor de vervaardiging van kunstmatige bloedvatprothesen en kunstmatige bloedvatprothese.
DK158972C (da) Farmaceutiske formuleringer indeholdende benzothiophenderivater
PH17094A (en) D-homo steroids and pharmaceutical preparation thereof
IT8009583A0 (it) Sostituiti e relativi metodi di derivati del benzofurano 2preparazione
DE2861254D1 (en) Method of treating intraocular lens and the like
NO157403C (no) Middel for behandling av saar.
AR241136A1 (es) Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada"
ATA91380A (de) Verfahren zur herstellung von prothesenschaeften und hiernach hergestellter prothesenschaft
ES507001A0 (es) Procedimiento para la fabricacion de derivados 2 substitui- dos del feniltiazol.
NO881436L (no) Fremgangsmaate for matriksbehandling av en oljebroenn.
JPS51116092A (en) Footwear for automatically treating defecation of seriously limbs handicapped patient or the like
ATE23112T1 (de) Verwendung von 1-(p-isopropoxyethoxymethylphenoxy)-3-isopropylamino-propan-2-ol zur herstellung eines arzneimittels zur senkung des augeninnendrucks.
ES2028891T3 (es) Material hidrofilo biocompatible y su proceso de fabricacion.
EP0122178A3 (en) Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
GR3005231T3 (fi)
SE8201308D0 (sv) Alkylendiaminderivat och forfarande for framstellning derav
SU875876A1 (ru) Способ изготовления упругих элементов из сплавов на основе никелида титана
EP0155214A3 (en) 2-sulfamoyl-1h-indole derivatives for the treatment of elevated intraocular pressure
IT1168492B (it) Procedimento per la lavorazione delle pelli naturali
NO822587L (no) Fremgangsmaate for behandling eller profylakse av hjertesykdommer

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: MERCK & CO., INC.