AU5544696A - Solid phase sequencing of biopolymers - Google Patents

Solid phase sequencing of biopolymers

Info

Publication number
AU5544696A
AU5544696A AU55446/96A AU5544696A AU5544696A AU 5544696 A AU5544696 A AU 5544696A AU 55446/96 A AU55446/96 A AU 55446/96A AU 5544696 A AU5544696 A AU 5544696A AU 5544696 A AU5544696 A AU 5544696A
Authority
AU
Australia
Prior art keywords
sequence
nucleic acid
target
mass
strand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU55446/96A
Other languages
English (en)
Inventor
Charles R. Cantor
Dong-Jing Fu
Hubert Koster
Cassandra L Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston University
Original Assignee
Boston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/614,151 external-priority patent/US6436635B1/en
Application filed by Boston University filed Critical Boston University
Publication of AU5544696A publication Critical patent/AU5544696A/en
Priority to AU42518/00A priority Critical patent/AU758454B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AU55446/96A 1995-04-11 1996-04-10 Solid phase sequencing of biopolymers Abandoned AU5544696A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU42518/00A AU758454B2 (en) 1995-04-11 2000-06-19 Solid phase sequencing of biopolymers

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US42000995A 1995-04-11 1995-04-11
US41999495A 1995-04-11 1995-04-11
US419994 1995-04-11
US420009 1995-04-11
US08/614,151 US6436635B1 (en) 1992-11-06 1996-03-12 Solid phase sequencing of double-stranded nucleic acids
US614151 1996-03-12
PCT/US1996/005136 WO1996032504A2 (fr) 1995-04-11 1996-04-10 Sequençage de biopolymeres en phase solide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU42518/00A Division AU758454B2 (en) 1995-04-11 2000-06-19 Solid phase sequencing of biopolymers

Publications (1)

Publication Number Publication Date
AU5544696A true AU5544696A (en) 1996-10-30

Family

ID=27411260

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55446/96A Abandoned AU5544696A (en) 1995-04-11 1996-04-10 Solid phase sequencing of biopolymers

Country Status (5)

Country Link
EP (1) EP0830460A1 (fr)
JP (1) JPH11503611A (fr)
AU (1) AU5544696A (fr)
CA (1) CA2218188A1 (fr)
WO (1) WO1996032504A2 (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
WO1994016101A2 (fr) 1993-01-07 1994-07-21 Koester Hubert Sequençage d'adn par spectrometrie de masse
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6428955B1 (en) * 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6146854A (en) * 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
DE19543065C2 (de) * 1995-11-09 2002-10-31 Gag Bioscience Gmbh Zentrum Fu Verfahren zur Genomanalyse und Mittel zur Durchführung des Verfahrens
CA2248084A1 (fr) * 1996-03-04 1997-09-12 Genetrace Systems, Inc. Methodes de criblage des acides nucleiques par spectrometrie de masse
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
GB9622665D0 (en) * 1996-10-31 1997-01-08 Zeneca Ltd Methods
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
DE19782095T1 (de) * 1996-11-06 2000-03-23 Sequenom Inc DNA-Diagnose auf der Basis von Massenspektrometrie
US6699668B1 (en) 1997-01-15 2004-03-02 Xzillion Gmbh & Co. Mass label linked hybridisation probes
NZ336769A (en) * 1997-01-15 2001-01-26 Brax Group Ltd Method of determining hybridization of a probe to a target nucleic acid
US6117634A (en) * 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
US6197557B1 (en) 1997-03-05 2001-03-06 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
WO1998040520A1 (fr) * 1997-03-14 1998-09-17 Hybridon, Inc. Methode de sequençage d'acides nucleiques modifies au moyen d'une spectrometrie de masse a transformee de fourier a ionisation par electropulverisation
WO1998044152A1 (fr) * 1997-04-01 1998-10-08 Glaxo Group Limited Methode de sequençage d'acide nucleique
JP2002503954A (ja) * 1997-04-01 2002-02-05 グラクソ、グループ、リミテッド 核酸増幅法
WO1999002728A1 (fr) * 1997-07-11 1999-01-21 Brax Group Limited Caracterisation des acides nucleiques
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6268131B1 (en) * 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
FR2782325B1 (fr) * 1998-08-12 2002-05-24 Proteus Procede d'identification de sequences polynucleotidiques et/ou des proteines correspondantes a partir d'un echantillon d'acides nucleiques
US6723564B2 (en) * 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US6104028A (en) * 1998-05-29 2000-08-15 Genetrace Systems Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US7270958B2 (en) 1998-09-10 2007-09-18 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
DE19963536C2 (de) * 1999-12-20 2003-04-10 Epigenomics Ag Verfahren zur Analyse von Nukleinsäuresequenzen
JP2001204463A (ja) * 2000-01-27 2001-07-31 Toyo Kohan Co Ltd ヌクレオチド固定用担体
US20020142483A1 (en) 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121313A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in organs for transplantation
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
JP2003043037A (ja) * 2001-07-27 2003-02-13 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板、この基板の製造方法及び使用方法
GB0202462D0 (en) * 2002-02-04 2002-03-20 Tepnel Medical Ltd Nucleic acid analysis
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
EP2259068B1 (fr) 2003-01-16 2013-08-14 caprotec bioanalytics GmbH Composés de capture et procédés d'analyse protéomique
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US20120122099A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP2395098B1 (fr) 2004-03-26 2015-07-15 Agena Bioscience, Inc. Division spécifique de base de produits d'amplification spécifique à la méthylation en combinaison avec une analyse de masse
ES2641832T3 (es) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
GB0500996D0 (en) * 2005-01-18 2005-02-23 Delfts Diagnostic Labaratory B Detection method and materials therefor
CA2600184A1 (fr) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions utilisees pour identifier des virus secondaires
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
CA2616281C (fr) 2005-07-21 2014-04-22 Isis Pharmaceuticals, Inc. Procede pour l'identification et la quantification rapide de variants d'acide nucleique
US9550162B2 (en) * 2005-09-19 2017-01-24 Intematix Corporation Printing liquid solution arrays for inorganic combinatorial libraries
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0524069D0 (en) 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
US8192930B2 (en) 2006-02-08 2012-06-05 Illumina Cambridge Limited Method for sequencing a polynucleotide template
EP2010679A2 (fr) 2006-04-06 2009-01-07 Ibis Biosciences, Inc. Compositions pour l'identification de champignons
CA2663029C (fr) 2006-09-14 2016-07-19 Ibis Biosciences, Inc. Procede d'amplification ciblee de genome entier pour l'identification d'agents pathogenes
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
WO2008093098A2 (fr) 2007-02-02 2008-08-07 Illumina Cambridge Limited Procedes pour indexer des echantillons et sequencer de multiples matrices nucleotidiques
WO2008104002A2 (fr) 2007-02-23 2008-08-28 Ibis Biosciences, Inc. Procédé d'analyse d'adn médico-légale rapide
WO2008151023A2 (fr) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Procédés et compositions pour l'amplification par déplacement multiple d'acides nucléiques
US8901487B2 (en) 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US8067730B2 (en) 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
WO2009039122A2 (fr) 2007-09-17 2009-03-26 Sequenom, Inc. Dispositif de transfert d'échantillon robotique intégré
US8534447B2 (en) 2008-09-16 2013-09-17 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
EP2347254A2 (fr) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Unités de traitement d'échantillons, systèmes et procédés associés
EP2349549B1 (fr) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Cartouches de mélange, postes de mélange et kits, et système associé
WO2010038042A1 (fr) 2008-10-02 2010-04-08 Illumina Cambridge Ltd. Enrichissement d'échantillons d'acide nucléique pour des applications de séquençage
US8158936B2 (en) 2009-02-12 2012-04-17 Ibis Biosciences, Inc. Ionization probe assemblies
WO2010104798A1 (fr) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Procédés de détection d'un bioagent
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2011008972A1 (fr) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systèmes pour l'identification d'un bioagent
WO2011008971A1 (fr) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Appareil de levage et de montage
WO2011014811A1 (fr) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Amorces de capture et supports solides liés à une séquence de capture pour tests diagnostiques moléculaires
EP2462244B1 (fr) 2009-08-06 2016-07-20 Ibis Biosciences, Inc. Compositions de base déterminées non massiques pour détection d'acide nucléique
PT2669387T (pt) 2009-08-25 2016-09-20 Illumina Inc Métodos para selecção e amplificação de polinucleótidos
US8182994B2 (en) 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
ES2628739T3 (es) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
US9758840B2 (en) 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
EP2710144B1 (fr) 2011-05-19 2020-10-07 Agena Bioscience, Inc. Procédés d'identification d'acides nucléiques multiplexés
WO2013085572A2 (fr) 2011-07-14 2013-06-13 The George Washington University Collimation de panaches pour spectrométrie de masse avec ionisation par électropulvérisation en ablation au laser
WO2015057008A2 (fr) * 2013-10-18 2015-04-23 Seegene, Inc. Détection de séquence d'acide nucléique cible sur phase solide par clivage et extension de pto au moyen d'un dosage de hcto
EP4001430A1 (fr) 2015-04-24 2022-05-25 Agena Bioscience, Inc. Procédé multiplexé d'identification et de quantification d'allèles mineurs et de polymorphismes
WO2016172579A1 (fr) 2015-04-24 2016-10-27 Agena Bioscience, Inc, Procédés multiplexes permettant la détection et la quantification de variants mineurs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
WO1994016101A2 (fr) * 1993-01-07 1994-07-21 Koester Hubert Sequençage d'adn par spectrometrie de masse
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method

Also Published As

Publication number Publication date
EP0830460A1 (fr) 1998-03-25
JPH11503611A (ja) 1999-03-30
CA2218188A1 (fr) 1996-10-17
WO1996032504A3 (fr) 1996-11-14
WO1996032504A2 (fr) 1996-10-17

Similar Documents

Publication Publication Date Title
US6991903B2 (en) Solid phase sequencing of double-stranded nucleic acids
US8758995B2 (en) Solid phase sequencing of biopolymers
AU5544696A (en) Solid phase sequencing of biopolymers
EP1015643B1 (fr) Procedes et reactifs d'analyse de la sequence nucleotidique des acides nucleiques
CA2220418C (fr) Determination de la taille d'oligonucleotides a l'aide d'amorces scindables
US5700642A (en) Oligonucleotide sizing using immobilized cleavable primers
US6194144B1 (en) DNA sequencing by mass spectrometry
EP0679196B1 (fr) Sequen age d'adn par spectrometrie de masse
EP1251136B1 (fr) Méthode et réactifs pour l'analyse de séquences d'acides nucléiques
AU725966B2 (en) Mass label linked hybridisation probes
WO1997037041A2 (fr) Sequençage d'adn par spectrometrie de masse
WO1997037041A9 (fr) Sequençage d'adn par spectrometrie de masse
US20050042625A1 (en) Mass label linked hybridisation probes
NZ502088A (en) Characterising nucleic acids using mass spectroscopy
AU758454B2 (en) Solid phase sequencing of biopolymers
US20060063193A1 (en) Solid phase sequencing of double-stranded nucleic acids
US6699668B1 (en) Mass label linked hybridisation probes
AU694940C (en) DNA sequencing by mass spectrometry

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted