AU523050B2 - Cyclopeptides - Google Patents

Cyclopeptides

Info

Publication number
AU523050B2
AU523050B2 AU40229/78A AU4022978A AU523050B2 AU 523050 B2 AU523050 B2 AU 523050B2 AU 40229/78 A AU40229/78 A AU 40229/78A AU 4022978 A AU4022978 A AU 4022978A AU 523050 B2 AU523050 B2 AU 523050B2
Authority
AU
Australia
Prior art keywords
phe
trp
radical
amino
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU40229/78A
Other languages
English (en)
Other versions
AU4022978A (en
Inventor
Bruno Kamber And Peter Sieber Hans Rink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU4022978A publication Critical patent/AU4022978A/en
Application granted granted Critical
Publication of AU523050B2 publication Critical patent/AU523050B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU40229/78A 1977-09-28 1978-09-27 Cyclopeptides Expired AU523050B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LULU78191 1977-09-28
LU78191A LU78191A1 (de) 1977-09-28 1977-09-28 Verfahren zur herstellung von neuen cyclopeptiden

Publications (2)

Publication Number Publication Date
AU4022978A AU4022978A (en) 1980-04-03
AU523050B2 true AU523050B2 (en) 1982-07-08

Family

ID=19728716

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40229/78A Expired AU523050B2 (en) 1977-09-28 1978-09-27 Cyclopeptides

Country Status (18)

Country Link
US (1) US4238481A (enExample)
EP (1) EP0001295B1 (enExample)
JP (1) JPS5459293A (enExample)
AT (1) AT370090B (enExample)
AU (1) AU523050B2 (enExample)
CA (1) CA1111841A (enExample)
DD (1) DD140142A5 (enExample)
DE (1) DE2861672D1 (enExample)
DK (1) DK151034C (enExample)
ES (1) ES473677A1 (enExample)
FI (1) FI68246C (enExample)
HU (1) HU184612B (enExample)
IE (1) IE47380B1 (enExample)
IL (1) IL55643A (enExample)
LU (1) LU78191A1 (enExample)
NO (1) NO148957C (enExample)
NZ (1) NZ188517A (enExample)
ZA (1) ZA785488B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328214A (en) * 1979-07-04 1982-05-04 Ciba-Geigy Corporation Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4369179A (en) * 1979-12-14 1983-01-18 Ciba-Geigy Corporation Acylpeptides
DD155985A5 (de) * 1979-12-21 1982-07-21 Ciba Geigy Ag Verfahren zur herstellung cyclischr octapeptide
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
DE3264693D1 (en) * 1981-12-24 1985-08-14 Ciba Geigy Ag Cyclic octapeptides and pharmaceutical compositions thereof, and processes for their production and use
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
CA2053250A1 (en) * 1989-04-26 1990-10-27 David H. Coy Linear somatostatin analogs
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
RU2177006C2 (ru) * 1995-09-29 2001-12-20 Биомежер Инкорпорэйтед Циклические пептидные аналоги соматостатина
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
AU7655098A (en) * 1997-05-13 1998-12-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
EP0981364B1 (en) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
PT980253E (pt) * 1997-05-13 2004-08-31 Conseils De Rec Appl Scient S Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
AU2002305845B2 (en) 2001-06-08 2006-03-30 Ipsen Pharma S.A.S. Somatostatin-dopamine chimeric analogs
DK1511761T3 (da) * 2003-04-07 2006-11-27 Novetide Ltd Fremgangsmåde til fremstilling af cykliske peptider
US8709998B2 (en) 2003-04-22 2014-04-29 Ipsen Pharma S.A.S. Peptide vectors
JP5728380B2 (ja) 2008-06-12 2015-06-03 シンタクシン リミテッドＳｙｎｔａｘｉｎ Ｌｉｍｉｔｅｄ 神経内分泌疾患の抑制
BRPI0915142A8 (pt) 2008-06-12 2018-01-02 Syntaxin Ltd Polipeptídeos, ácido nucleico e usos dos mesmos
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
CA2822442C (en) 2010-12-22 2021-03-16 The Salk Institute For Biological Studies Cyclic crf antagonist peptides
DK3007704T3 (da) 2013-06-13 2021-03-29 Antisense Therapeutics Ltd Kombinationsterapi til akromegali
TW202540153A (zh) 2023-12-15 2025-10-16 美商紐羅克里生物科學有限公司 脂肪酸結合環肽
TW202544027A (zh) 2024-04-19 2025-11-16 美商紐羅克里生物科學有限公司 促皮質素釋放因子受體２（ｃｒｆｒ２）促效劑
WO2026064495A1 (en) 2024-09-20 2026-03-26 Neurocrine Biosciences, Inc. Chemically modified peptides and use thereof
WO2026064486A1 (en) 2024-09-20 2026-03-26 Neurocrine Biosciences, Inc. Chemically modified peptides and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011182A (en) * 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
US4000259A (en) * 1975-06-16 1976-12-28 American Home Products Corporation Cyclic dodecapeptide analogs of somatostatin and intermediates
NL7607987A (nl) * 1975-08-08 1977-02-10 Merck & Co Inc Werkwijze voor het bereiden van peptiden.
US3988304A (en) * 1975-08-25 1976-10-26 American Home Products Corporation Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4133805A (en) * 1975-12-16 1979-01-09 American Home Products Corporation Cyclic undecapeptides related to somatostatin and intermediates therefor
US4054558A (en) * 1976-05-24 1977-10-18 American Home Products Corporation Cyclic dodecapeptide and intermediates therefor
DE2860734D1 (en) * 1977-06-08 1981-09-03 Merck & Co Inc Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
US4115554A (en) * 1977-08-29 1978-09-19 Merck & Co., Inc. Somatostatin analogs

Also Published As

Publication number Publication date
FI68246B (fi) 1985-04-30
HU184612B (en) 1984-09-28
NO783268L (no) 1979-03-29
NO148957C (no) 1984-01-18
DE2861672D1 (en) 1982-04-15
DK151034B (da) 1987-10-12
DD140142A5 (de) 1980-02-13
EP0001295B1 (de) 1982-03-17
FI782907A7 (fi) 1979-03-29
AU4022978A (en) 1980-04-03
EP0001295A3 (en) 1979-06-13
CA1111841A (en) 1981-11-03
DK151034C (da) 1988-02-22
DK428478A (da) 1979-03-29
FI68246C (fi) 1985-08-12
IL55643A0 (en) 1978-12-17
IL55643A (en) 1981-12-31
IE781931L (en) 1979-03-28
ZA785488B (en) 1979-09-26
US4238481A (en) 1980-12-09
LU78191A1 (de) 1979-05-25
JPS6218560B2 (enExample) 1987-04-23
AT370090B (de) 1983-02-25
ES473677A1 (es) 1980-05-16
NZ188517A (en) 1981-04-24
JPS5459293A (en) 1979-05-12
IE47380B1 (en) 1984-03-07
ATA698278A (de) 1982-07-15
NO148957B (no) 1983-10-10
EP0001295A2 (de) 1979-04-04

Similar Documents

Publication Publication Date Title
AU4022978A (en) Cyclopeptides
AU3409978A (en) 4-acylaminophenyl-ethanolamines
AU3782678A (en) 1-acyl-2-cyanoaziridines
AU3662478A (en) Pyridobenzodiazepines
AU3780378A (en) Circuit-tester
AU3347978A (en) Phenyl-benzimidazoyl-furanes
AU3662278A (en) Pyridobenzoiazepines
AU3770478A (en) 3-indolyl-tertiary butylaminopropanole
AU3216478A (en) Phenylcarbamoyl-2-pyrazolines
AU3216278A (en) Phenylcarbamoyl-pyrazolines
AU3887178A (en) 6-deoxyneamines
AU3732478A (en) a-ETHYNYL TRYTOPHANES
AU3307178A (en) Chloroacetanylides
AU3239278A (en) Dithienylalkylamines
AU3764478A (en) Benzylpyrimidines
AU3815178A (en) 7a-Methoxycephalosporins
AU3492478A (en) 4-alkylthio-2-trifluoromethylalkanesulfonides
AU3821078A (en) Imidazo-isoquinoline-diones
AU3401278A (en) Sipper-seal
AU3732678A (en) Alpha-vinyl tryptophanes
AU3706678A (en) Pyridazinylhydrazines
AU3418778A (en) Hydroxylated-1d-2d-methylene-steroids
AU3850578A (en) 1-phenylethanolamines
AU3790378A (en) Amidino-benzylpyrimidines
AU3670578A (en) 4-phenyl-8-amino-tetrahydroisoquinolines