AU505215B2 - Substituted indoles having cardial rate lowering activity - Google Patents

Substituted indoles having cardial rate lowering activity

Info

Publication number
AU505215B2
AU505215B2 AU87916/75A AU8791675A AU505215B2 AU 505215 B2 AU505215 B2 AU 505215B2 AU 87916/75 A AU87916/75 A AU 87916/75A AU 8791675 A AU8791675 A AU 8791675A AU 505215 B2 AU505215 B2 AU 505215B2
Authority
AU
Australia
Prior art keywords
cardial
lowering activity
substituted indoles
rate lowering
rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU87916/75A
Other languages
English (en)
Other versions
AU8791675A (en
Inventor
M. McCOMSEY D ZELASKO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
McNeil Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc, McNeil Laboratories Inc filed Critical McNeilab Inc
Publication of AU8791675A publication Critical patent/AU8791675A/en
Application granted granted Critical
Publication of AU505215B2 publication Critical patent/AU505215B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU87916/75A 1974-12-30 1975-12-30 Substituted indoles having cardial rate lowering activity Expired AU505215B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53761274A 1974-12-30 1974-12-30
USUS537,612 1974-12-30
US63179875A 1975-11-13 1975-11-13
USUS631,798 1975-11-13

Publications (2)

Publication Number Publication Date
AU8791675A AU8791675A (en) 1977-07-07
AU505215B2 true AU505215B2 (en) 1979-11-15

Family

ID=27065555

Family Applications (1)

Application Number Title Priority Date Filing Date
AU87916/75A Expired AU505215B2 (en) 1974-12-30 1975-12-30 Substituted indoles having cardial rate lowering activity

Country Status (27)

Country Link
JP (1) JPS51131872A (fr)
AR (1) AR219052A1 (fr)
AT (1) AT356648B (fr)
AU (1) AU505215B2 (fr)
CA (1) CA1065874A (fr)
CH (1) CH622516A5 (fr)
DD (1) DD125781A5 (fr)
DE (1) DE2559211A1 (fr)
DK (1) DK580175A (fr)
ES (1) ES443935A1 (fr)
FI (1) FI64590C (fr)
FR (2) FR2296413A1 (fr)
GB (1) GB1527510A (fr)
HU (2) HU174948B (fr)
IE (1) IE42390B1 (fr)
IL (1) IL48756A (fr)
IN (1) IN142735B (fr)
IT (1) IT1052654B (fr)
NL (1) NL7515100A (fr)
NO (1) NO145383C (fr)
NZ (1) NZ179580A (fr)
PH (1) PH12328A (fr)
PL (1) PL99353B1 (fr)
RO (1) RO69196A (fr)
SE (1) SE422210B (fr)
SU (1) SU667132A3 (fr)
YU (1) YU332275A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595056A (en) * 1976-10-12 1981-08-05 Wellcome Found Pharmaceutical combination
FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique
US4558048A (en) * 1984-04-06 1985-12-10 Pfizer Inc. Method of treating diarrhoea using indole compounds
EP1216988A4 (fr) * 1999-09-28 2005-04-20 Nihon Nohyaku Co Ltd Derives de thioalkylamine et methode de preparation desdits derives
UA79504C2 (en) * 2002-11-07 2007-06-25 Organon Nv Indols for treating diseases associated with androgen receptors
KR20050072812A (ko) 2002-11-07 2005-07-12 악조 노벨 엔.브이. 안드로겐-수용체와 관련된 질병의 치료에 효과적인 인돌
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
WO2007020653A1 (fr) * 2005-08-12 2007-02-22 Suven Life Sciences Limited Dérivés de thioéther en tant que ligands 5-ht6 fonctionnels

Also Published As

Publication number Publication date
IT1052654B (it) 1981-07-20
HU174948B (hu) 1980-04-28
DK580175A (da) 1976-07-01
IE42390B1 (en) 1980-07-30
FR2315921B1 (fr) 1979-09-28
FR2315921A1 (fr) 1977-01-28
YU332275A (en) 1983-02-28
IL48756A (en) 1979-03-12
JPS51131872A (en) 1976-11-16
IL48756A0 (en) 1976-02-29
FI753669A (fr) 1976-07-01
DD125781A5 (fr) 1977-05-18
AU8791675A (en) 1977-07-07
CA1065874A (fr) 1979-11-06
AR219052A1 (es) 1980-07-31
GB1527510A (en) 1978-10-04
NZ179580A (en) 1978-04-03
SE7514458L (sv) 1976-07-01
IE42390L (en) 1976-06-30
ATA986075A (de) 1979-10-15
FR2296413A1 (fr) 1976-07-30
DE2559211A1 (de) 1976-07-08
NO145383B (no) 1981-11-30
FI64590B (fi) 1983-08-31
HU174949B (hu) 1980-04-28
PL99353B1 (pl) 1978-07-31
NL7515100A (nl) 1976-07-02
SU667132A3 (ru) 1979-06-05
PH12328A (en) 1979-01-16
FI64590C (fi) 1983-12-12
NO754313L (fr) 1976-07-01
CH622516A5 (en) 1981-04-15
AT356648B (de) 1980-05-12
FR2296413B1 (fr) 1980-06-27
NO145383C (no) 1982-03-10
ES443935A1 (es) 1977-08-16
SE422210B (sv) 1982-02-22
RO69196A (fr) 1980-08-15
IN142735B (fr) 1977-08-20

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