AU472686B2 - TRIAZOLO (4,3-a) (1,4) BENZODIAZEPINES - Google Patents

TRIAZOLO (4,3-a) (1,4) BENZODIAZEPINES

Info

Publication number
AU472686B2
AU472686B2 AU41640/72A AU4164072A AU472686B2 AU 472686 B2 AU472686 B2 AU 472686B2 AU 41640/72 A AU41640/72 A AU 41640/72A AU 4164072 A AU4164072 A AU 4164072A AU 472686 B2 AU472686 B2 AU 472686B2
Authority
AU
Australia
Prior art keywords
benzodiazepines
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU41640/72A
Other languages
English (en)
Other versions
AU4164072A (en
Inventor
Jackson Boling Hester, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU4164072A publication Critical patent/AU4164072A/en
Application granted granted Critical
Publication of AU472686B2 publication Critical patent/AU472686B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU41640/72A 1971-05-11 1972-04-27 TRIAZOLO (4,3-a) (1,4) BENZODIAZEPINES Expired AU472686B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14241871A 1971-05-11 1971-05-11
USUS142,418 1971-05-11

Publications (2)

Publication Number Publication Date
AU4164072A AU4164072A (en) 1973-11-01
AU472686B2 true AU472686B2 (en) 1976-06-03

Family

ID=22499766

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41640/72A Expired AU472686B2 (en) 1971-05-11 1972-04-27 TRIAZOLO (4,3-a) (1,4) BENZODIAZEPINES

Country Status (9)

Country Link
US (2) US3681343A (show.php)
AU (1) AU472686B2 (show.php)
BE (1) BE783273A (show.php)
CH (3) CH582180A5 (show.php)
DE (1) DE2221790A1 (show.php)
FR (1) FR2137713B1 (show.php)
GB (2) GB1380880A (show.php)
NL (1) NL7206302A (show.php)
ZA (1) ZA722560B (show.php)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2156472A1 (de) 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
JPS4932874B1 (show.php) * 1970-12-11 1974-09-03
US3946032A (en) * 1971-04-08 1976-03-23 Ciba-Geigy Corporation Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde
CH545302A (de) * 1971-04-08 1974-01-13 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US4902794A (en) * 1971-04-28 1990-02-20 The Upjohn Company Triazolo-benzodiazepines
US4250094A (en) * 1971-04-28 1981-02-10 The Upjohn Company 1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
DE2308280A1 (de) * 1971-11-15 1973-09-06 Ciba Geigy Ag Verfahren zur herstellung von neuen diazepinderivaten
US3886174A (en) * 1971-11-22 1975-05-27 Upjohn Co 1-Substituted-6-phenyl-4H-s-triazolo{8 4,3-a{9 {8 1,4{9 benzodiazepines
CH567031A5 (show.php) * 1972-05-18 1975-09-30 Ciba Geigy Ag
US3879406A (en) * 1972-07-13 1975-04-22 Hoffmann La Roche Preparation of triazolobenzodiazepines
IE38931B1 (en) * 1973-03-09 1978-07-05 Lipha Triazolobenzodiazepines
US4213982A (en) 1973-05-29 1980-07-22 E. R. Squibb & Sons, Inc. Novel 4H-S-triazolo[4,3-A] [1,5]benzodiazepin-5-ones
IE41197B1 (en) 1973-05-29 1979-11-07 Squibb & Sons Inc 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones
AT338799B (de) 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
JPS5747914B2 (show.php) * 1974-04-12 1982-10-13
US3910944A (en) * 1974-11-20 1975-10-07 Upjohn Co Spiro(cyclopropane-1,4{40 -(4H)-s-triazolo-(4,3-a)(1,4)benzodiazepines)
US4044016A (en) * 1975-01-13 1977-08-23 Hoffmann-La Roche Inc. Preparation of triazolo benzodiazepines and novel compounds
US4018788A (en) * 1975-06-16 1977-04-19 The Upjohn Company 6-(O-Halophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine
US4226772A (en) * 1976-03-15 1980-10-07 The Upjohn Company 1-[(Dialkylamino)methyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazolobenzodiazepine N1 -oxide
US4009175A (en) * 1976-03-15 1977-02-22 The Upjohn Company 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines
US4415583A (en) * 1980-03-27 1983-11-15 The Upjohn Company Process for inducing hypnosis
US4374842A (en) * 1980-04-18 1983-02-22 Shionogi & Co., Ltd. 4,1-Benzoxazepines and compositions
US4479959A (en) * 1981-01-29 1984-10-30 The Upjohn Company Process for inducing hypnosis
US4444781A (en) * 1981-04-06 1984-04-24 The Upjohn Company Process for inducing hypnosis
CA2799420C (en) * 2010-05-14 2018-10-02 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
WO2011143660A2 (en) 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia
AU2015201727B2 (en) * 2010-05-14 2018-03-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
CA2799381A1 (en) 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Male contraceptive compositions and methods of use
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
RU2016105108A (ru) 2013-07-25 2017-08-30 Дана-Фарбер Кэнсер Инститьют, Инк. Ингибиторы факторов транскрипции и их применение
RU2016122654A (ru) 2013-11-08 2017-12-14 Дана-Фарбер Кэнсер Инститьют, Инк. Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3099677A4 (en) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
EP3110424A1 (en) 2014-02-28 2017-01-04 Tensha Therapeutics, Inc. Treatment of conditions associated with hyperinsulinaemia
CA2952830C (en) 2014-06-20 2022-11-01 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
KR20170032473A (ko) 2014-08-08 2017-03-22 다나-파버 캔서 인스티튜트 인크. 디아제판 유도체 및 그의 용도
MX2017001757A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
UA122130C2 (uk) 2014-10-27 2020-09-25 Тенша Терапеутікс, Інк. Інгібітори бромодомену
CA2986441A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
MX2018003030A (es) 2015-09-11 2018-04-11 Dana Farber Cancer Inst Inc Acetamida tienotriazolodiazepinas y usos de las mismas.
KR20180049058A (ko) 2015-09-11 2018-05-10 다나-파버 캔서 인스티튜트 인크. 시아노 티에노트리아졸로디아제핀 및 그의 용도
JP7385356B2 (ja) 2015-11-25 2023-11-22 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド 二価ブロモドメインインヒビターおよびそれらの使用
AU2018265615A1 (en) 2017-05-12 2019-10-03 Domain Therapeutics Substituted heterocyclic compounds as allosteric modulators of group II metabotropic glutamate receptors
CA3167543A1 (en) 2020-03-31 2021-10-07 F. Hoffmann-La Roche Ag Benzodiazepine derivatives as gaba a gamma1 pams
AR127157A1 (es) 2021-09-29 2023-12-27 Hoffmann La Roche NUEVOS DERIVADOS DE BENZODIAZEPINA COMO MODULADORES ALOSTÉRICOS POSITIVOS DE GABAA g1
AU2022360084A1 (en) 2021-10-06 2024-03-28 F. Hoffmann-La Roche Ag Benzodiazepine derivatives as positive allosteric modulators of the gaba a gamma1 receptor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH540247A (de) * 1967-04-21 1973-09-28 Ciba Geigy Ag Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen
JPS4837280B1 (show.php) * 1969-03-08 1973-11-09
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives

Also Published As

Publication number Publication date
CH582180A5 (show.php) 1976-11-30
CH573942A5 (show.php) 1976-03-31
BE783273A (fr) 1972-11-10
GB1377435A (en) 1974-12-18
GB1380880A (en) 1975-01-15
AU4164072A (en) 1973-11-01
DE2221790A1 (de) 1972-11-23
ZA722560B (en) 1973-02-28
USRE28505E (en) 1975-08-05
NL7206302A (show.php) 1972-11-14
FR2137713B1 (show.php) 1975-12-26
US3681343A (en) 1972-08-01
CH572485A5 (show.php) 1976-02-13
FR2137713A1 (show.php) 1972-12-29

Similar Documents

Publication Publication Date Title
AU472686B2 (en) TRIAZOLO (4,3-a) (1,4) BENZODIAZEPINES
IL33859A0 (en) S-triazolo(4,3-a)(1,4)-benzodiazepines
CA999860A (en) Imidazo-(1,2-a)-(benzodiazepine-1,4) compounds
ZA722627B (en) 4h-5-triazolo(4,3-a)(1,4)benzodiazepines
PH9315A (en) Triazolo(4,3-a)(1,4)benzodiazepine derivatives
CA973880A (en) Tricyclic benzodiazepines
CA1003412A (en) Triazolo benzodiazepines
CA1034125A (en) Pyrimido benzodiazepines
AU458173B2 (en) 1-substituted-6-phenyl-4h-triazolo (4,3, a) (1,4) benzodiazepines
CA1010032A (en) Imidazo (3,4-d)-dibenzo-oxazepines, -thiazepines, and -diazepines
AU475124B2 (en) Benzodiazepine derivatives
AU454571B2 (en) Novel benzodiazepines
CA970373A (en) Pyrazolo (3,4-b) pyridine-5-carboxamides
AU471193B2 (en) Benzodiazepine derivatives
CA995214A (en) Benzodiazepines
ZA723636B (en) 1,6-disubstituted-4h-s-triazolo(4,3-a)(1,4)-benzodiazepines
AU456535B2 (en) 1,6-disubstituted 4h-2-triazolo [4,3-a] [1,4] benzodiazepines and the production thereof
CA963464A (en) 4-styrylphenyl-triazole (4,5-d) pyrimidin-7-ol compounds
PH9908A (en) 2,9-dihydro-3h-dibenzo(c,f)-s-triazolo(4,3-a)-azepin-3-ones
AU475861B2 (en) 6-phenyl-4h-v-triazolo /1,5-a/1,4/ benzodiazepines
CA1013741A (en) Benzodiazepines
AU464682B2 (en) Benzodiazepines
PH9374A (en) 1-methyl-6-(o-chlorophenyl)-4h-s-triazolo(4,3-a)(1,4)-benzodiazepine
CA925510A (en) (pyrazolo(3,4-b)pyridin-5-yl-formamidoethyl) phenylsulfonylureas
AU471711B2 (en) Triazolo benzodiazepine compositions