AU4704693A - Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists - Google Patents

Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists

Info

Publication number
AU4704693A
AU4704693A AU47046/93A AU4704693A AU4704693A AU 4704693 A AU4704693 A AU 4704693A AU 47046/93 A AU47046/93 A AU 47046/93A AU 4704693 A AU4704693 A AU 4704693A AU 4704693 A AU4704693 A AU 4704693A
Authority
AU
Australia
Prior art keywords
indole
methyl
dihydropyrrolo
pyridylcarbamoyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU47046/93A
Other languages
English (en)
Inventor
Thomas Paul Blackburn
Ian Thomson Forbes
Peter Ham
Roger Thomas Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929217674A external-priority patent/GB9217674D0/en
Priority claimed from GB939306461A external-priority patent/GB9306461D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU4704693A publication Critical patent/AU4704693A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Indole Compounds (AREA)
AU47046/93A 1992-08-20 1993-07-29 Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists Abandoned AU4704693A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9217674 1992-08-20
GB929217674A GB9217674D0 (en) 1992-08-20 1992-08-20 Novel compounds
GB9306461 1993-03-29
GB939306461A GB9306461D0 (en) 1993-03-29 1993-03-29 Novel compounds
PCT/EP1993/002031 WO1994004533A1 (en) 1992-08-20 1993-07-29 Condensed indole derivatives as 5ht2c and 5ht2b antagonists

Publications (1)

Publication Number Publication Date
AU4704693A true AU4704693A (en) 1994-03-15

Family

ID=26301461

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47046/93A Abandoned AU4704693A (en) 1992-08-20 1993-07-29 Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists

Country Status (13)

Country Link
EP (1) EP0656003A1 (zh)
JP (1) JPH08500580A (zh)
CN (1) CN1086819A (zh)
AP (1) AP9300560A0 (zh)
AU (1) AU4704693A (zh)
CA (1) CA2142721A1 (zh)
IL (1) IL106737A0 (zh)
MA (1) MA22955A1 (zh)
MX (1) MX9305037A (zh)
NZ (1) NZ254785A (zh)
SI (1) SI9300438A (zh)
TW (1) TW248557B (zh)
WO (1) WO1994004533A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306460D0 (en) * 1993-03-29 1993-05-19 Smithkline Beecham Plc Novel compounds
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
GB9402542D0 (en) * 1994-02-10 1994-04-06 Smith Kline Beecham Plc Novel compounds
JPH09512025A (ja) * 1994-04-23 1997-12-02 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ▲下２ｃ▼および５ｈｔ▲下２ｂ▼アンタゴニストとしての三環式誘導体
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
GB9420999D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
EP0807104A2 (en) * 1995-02-02 1997-11-19 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht 2c? receptor antagonist activity
KR19980701879A (ko) * 1995-02-02 1998-06-25 피터 기딩스 5-히드록시트립타민 수용체 길항제로서의 인돌 유도체
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9612883D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
JP2001508767A (ja) * 1996-12-02 2001-07-03 藤沢薬品工業株式会社 ５―ｈｔ拮抗作用を有するインドール―ウレア誘導体
GB9724372D0 (en) * 1997-11-18 1998-01-14 Smithkline Beecham Plc Novel compounds
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2807754A1 (fr) * 2000-04-13 2001-10-19 Adir Nouveaux derives de cyclobuta-indole carboxamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1616192A1 (en) * 2002-12-23 2006-01-18 Bayer HealthCare AG Diagnostics and therapeutics for diseases assosciated with 5-hydroxytryptamine (serotonin) receptor 2b (5-hteb)
GB0305553D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
WO2014049153A1 (en) * 2012-09-28 2014-04-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonists of the 5-ht2b receptor for use in the prevention or treatment of spasticity
US20230312562A1 (en) * 2020-07-02 2023-10-05 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline -containing compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06500551A (ja) * 1990-09-13 1994-01-20 ビーチャム・グループ・パブリック・リミテッド・カンパニー ５ｈｔ受容体アンタゴニストとしてのインドールウレア

Also Published As

Publication number Publication date
TW248557B (zh) 1995-06-01
EP0656003A1 (en) 1995-06-07
NZ254785A (en) 1995-09-26
MX9305037A (es) 1994-03-31
CA2142721A1 (en) 1994-03-03
CN1086819A (zh) 1994-05-18
MA22955A1 (fr) 1994-04-01
WO1994004533A1 (en) 1994-03-03
IL106737A0 (en) 1994-05-30
JPH08500580A (ja) 1996-01-23
SI9300438A (en) 1994-03-31
AP9300560A0 (en) 1995-02-19

Similar Documents

Publication Publication Date Title
AU4704693A (en) Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists
DE69221059T2 (de) Indolderivate und antiulcerose Zubereitungen
DE60125373T2 (de) Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung
US5089496A (en) Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
FI96768B (fi) Menetelmä valmistaa farmakologisesti arvokasta bentso/5,6/sykloheptapyridiiniä
DE60214990T2 (de) Benzolsulfonsäureester-indol-5-yl als 5-ht6 rezeptor-antagonisten
RU2100357C1 (ru) Гетероариламины или их фармацевтически приемлемые соли и фармацевтическая композиция на их основе
DD259190A5 (de) Verfahren zur herstellung von substituierten bruecken-diazabic ycloalkyl-chinolon-carbonsaeuren
WO1993018028A1 (en) Indole derivatives as 5ht1c antagonists
JPS6355513B2 (zh)
WO1996011929A1 (en) Biheteroaryl-carbonyl and carboxamide derivatives with 5ht 2c/2b antagonists activity
DE60309852T2 (de) Chinolin- und aza-indolderivate und deren verwendung als 5-ht6 liganden
EP0705832B1 (en) Serotonergic modulators
US5296478A (en) 1-substituted oxindoles as cognition enhancers
HU205354B (en) Process for producing new tricyclic benzimidazoles and pharmaceutical compositions comprising same
NZ238141A (en) 1,2,3,4,4a,10b-hexahydro-6-(sulphonamidophenyl)benzo(c)(1,6)naphthyridine derivatives, preparation and pharmaceutical compositions thereof
WO1996011930A1 (en) Cns-active pyridinylurea derivatives
JP3014001B2 (ja) 興奮性アミノ酸拮抗剤
US5563147A (en) Serotonerbic tetrahydropyridoindoles
JPH08502273A (ja) ５−ｈｔ▲下４▼レセプターアンタゴニスト用複素環式エステルまたはアミド
HU220874B1 (en) Imidazopyridine-azolidinones, process for producing them, the use thereof and pharmaceutical compositions containing them
EP0757687A1 (en) Tricyclic derivatives as 5ht 2c? and 5ht 2b? antagonists
EP0743946A1 (en) 5ht2b receptor antagonists condensed indoles
KR0173451B1 (ko) 피리미도인돌 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
US5665726A (en) Benzo[5,6]cycloheptapyridines, compositions and methods of use