AU468447B2 - 2, 4-diamino-5-benzyl-pyrimidines - Google Patents

2, 4-diamino-5-benzyl-pyrimidines

Info

Publication number
AU468447B2
AU468447B2 AU41174/72A AU4117472A AU468447B2 AU 468447 B2 AU468447 B2 AU 468447B2 AU 41174/72 A AU41174/72 A AU 41174/72A AU 4117472 A AU4117472 A AU 4117472A AU 468447 B2 AU468447 B2 AU 468447B2
Authority
AU
Australia
Prior art keywords
pyrimidines
diamino
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU41174/72A
Other languages
English (en)
Other versions
AU4117472A (en
Inventor
Roth Barbara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of AU4117472A publication Critical patent/AU4117472A/en
Application granted granted Critical
Publication of AU468447B2 publication Critical patent/AU468447B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU41174/72A 1971-04-10 1972-04-14 2, 4-diamino-5-benzyl-pyrimidines Expired AU468447B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9639/71 1971-04-10
GB963971A GB1407971A (en) 1971-04-16 1971-04-16 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor

Publications (2)

Publication Number Publication Date
AU4117472A AU4117472A (en) 1973-10-18
AU468447B2 true AU468447B2 (en) 1976-01-15

Family

ID=9875880

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41174/72A Expired AU468447B2 (en) 1971-04-10 1972-04-14 2, 4-diamino-5-benzyl-pyrimidines

Country Status (13)

Country Link
JP (3) JPS5320511B1 (fr)
AU (1) AU468447B2 (fr)
BE (1) BE782153A (fr)
CA (1) CA967964A (fr)
CH (1) CH565160A5 (fr)
CS (1) CS181221B2 (fr)
DE (1) DE2218220A1 (fr)
DK (1) DK131466B (fr)
FR (1) FR2133752B1 (fr)
GB (1) GB1407971A (fr)
IL (3) IL39218A (fr)
NL (1) NL7205043A (fr)
SE (1) SE391180B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA738760B (en) * 1972-12-21 1974-08-28 Hoffmann La Roche Process for the manufacture of benzyl pyrimidines
GB1469521A (en) * 1973-01-05 1977-04-06 Wellcome Found Antimicrobial preparations
FR2502152A1 (fr) * 1981-03-20 1982-09-24 Panmedica Laboratoires Nouveaux derives solubles n2 substitues de la diamino-2,4-benzyl-5-pyrimidines, leur procede de preparation et medicaments les contenant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1090394A (fr) * 1953-03-11 1955-03-30 Wellcome Found Dérivés de pyrimidine et leur fabrication
FR1459417A (fr) * 1964-11-12 1966-04-29 Hoffmann La Roche Procédé pour la préparation de dérivés de pyrimidine
FR1518635A (fr) * 1965-07-08 1968-03-29 Wellcome Found Procédé de préparation de dérivés de la pyrimidine
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles

Also Published As

Publication number Publication date
CH565160A5 (fr) 1975-08-15
CS181221B2 (en) 1978-03-31
IL47921A0 (en) 1975-11-25
GB1407971A (en) 1975-10-01
IL39218A (en) 1976-10-31
JPS5422994B2 (fr) 1979-08-10
DE2218220A1 (de) 1972-11-02
JPS5320511B1 (fr) 1978-06-27
NL7205043A (fr) 1972-10-18
AU4117472A (en) 1973-10-18
JPS5430189A (en) 1979-03-06
IL47921A (en) 1976-10-31
DK131466B (da) 1975-07-21
JPS53111083A (en) 1978-09-28
DK131466C (fr) 1975-12-08
FR2133752A1 (fr) 1972-12-01
IL39218A0 (en) 1972-06-28
FR2133752B1 (fr) 1975-04-25
BE782153A (fr) 1972-10-16
CA967964A (en) 1975-05-20
SE391180B (sv) 1977-02-07

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