AU4379097A - Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism - Google Patents
Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholismInfo
- Publication number
- AU4379097A AU4379097A AU43790/97A AU4379097A AU4379097A AU 4379097 A AU4379097 A AU 4379097A AU 43790/97 A AU43790/97 A AU 43790/97A AU 4379097 A AU4379097 A AU 4379097A AU 4379097 A AU4379097 A AU 4379097A
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- treatment
- hydroxybutyric acid
- drug addiction
- alcoholism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010013663 drug dependence Diseases 0.000 title abstract 2
- 208000011117 substance-related disease Diseases 0.000 title abstract 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 title 1
- 208000007848 Alcoholism Diseases 0.000 title 1
- 201000007930 alcohol dependence Diseases 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI96A1732 | 1996-08-09 | ||
| IT96MI001732A IT1283782B1 (it) | 1996-08-09 | 1996-08-09 | Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo |
| PCT/EP1997/004309 WO1998006690A1 (en) | 1996-08-09 | 1997-08-07 | USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4379097A true AU4379097A (en) | 1998-03-06 |
Family
ID=11374795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU43790/97A Abandoned AU4379097A (en) | 1996-08-09 | 1997-08-07 | Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6436998B1 (OSRAM) |
| EP (1) | EP0932597B1 (OSRAM) |
| JP (1) | JP4259615B2 (OSRAM) |
| AT (1) | ATE215065T1 (OSRAM) |
| AU (1) | AU4379097A (OSRAM) |
| CA (1) | CA2263328C (OSRAM) |
| DE (1) | DE69711411T2 (OSRAM) |
| DK (1) | DK0932597T3 (OSRAM) |
| ES (1) | ES2174287T3 (OSRAM) |
| HU (1) | HU228595B1 (OSRAM) |
| IT (1) | IT1283782B1 (OSRAM) |
| PT (1) | PT932597E (OSRAM) |
| WO (1) | WO1998006690A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU779354B2 (en) * | 1998-12-23 | 2005-01-20 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
| FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| AU2003295393A1 (en) * | 2002-11-01 | 2004-06-07 | Baylor Research Institute | Ghb treatment methods |
| US7838556B2 (en) * | 2006-02-21 | 2010-11-23 | University Of Maryland, Baltimore | Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands |
| EP2062875A1 (en) * | 2007-11-13 | 2009-05-27 | LABORATORIO FARMACEUTICO C.T. S.r.l. | New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide |
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| US8771735B2 (en) * | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
| MX377251B (es) | 2010-03-24 | 2025-03-07 | Jazz Pharmaceuticals Inc Star | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas. |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| ITMI20132041A1 (it) * | 2013-12-06 | 2015-06-07 | Ct Lab Farm Srl | Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico. |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| ITUB20152860A1 (it) | 2015-08-04 | 2017-02-04 | Laboratorio Farm C T S R L | Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool |
| ITUA20164040A1 (it) * | 2016-06-01 | 2017-12-01 | Laboratorio Farm C T S R L | Procedimento per la preparazione di polimorfo a |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| BR112021006027A2 (pt) | 2018-11-19 | 2021-06-29 | Jazz Pharmaceuticals Ireland Limited | formulações de fármaco resistente a álcool |
| US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| WO2022076824A1 (en) | 2020-10-08 | 2022-04-14 | Jazz Pharmaceuticals Ireland Limited | Sodium oxybate to treat idiopathic hypersomnia |
| WO2023126076A1 (en) | 2022-01-03 | 2023-07-06 | Laboratorio Farmaceutico C.T. S.R.L. | Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| JP2026513019A (ja) | 2023-02-03 | 2026-04-22 | トリス・フアルマ・インコーポレーテツド | １晩１回の低ナトリウムオキシベート組成物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940258A (en) * | 1971-11-26 | 1976-02-24 | Gaf Corporation | Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide |
| JPS6016432B2 (ja) * | 1977-07-26 | 1985-04-25 | グレラン製薬株式会社 | 複素環式化合物類およびその製造法 |
| EP0461677B1 (en) * | 1987-02-23 | 1997-04-16 | Ono Pharmaceutical Co., Ltd. | Novel thiazolidine derivatives |
| IT1217783B (it) * | 1988-06-03 | 1990-03-30 | Farmaceutico Ct S R L Lab | Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative |
| IT1248588B (it) | 1991-06-28 | 1995-01-19 | Gaetano Crepaldi | Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari. |
| EP0763016B1 (en) * | 1994-06-01 | 2000-01-26 | Axys Pharmaceuticals, Inc. | Compositions and methods for treating mast-cell mediated conditions |
| NO307879B1 (no) * | 1995-09-18 | 2000-06-13 | Sankyo Co | Nye ureaderivater med ACAT-inhiberende aktivitet og farmasøytisk preparat inneholdende disse |
| ES2237850T3 (es) * | 1997-10-14 | 2005-08-01 | Mitsubishi Pharma Corporation | Compuestos de piperazina y su uso medicinal. |
-
1996
- 1996-08-09 IT IT96MI001732A patent/IT1283782B1/it active IP Right Grant
-
1997
- 1997-08-07 ES ES97941921T patent/ES2174287T3/es not_active Expired - Lifetime
- 1997-08-07 CA CA002263328A patent/CA2263328C/en not_active Expired - Lifetime
- 1997-08-07 DE DE69711411T patent/DE69711411T2/de not_active Expired - Lifetime
- 1997-08-07 WO PCT/EP1997/004309 patent/WO1998006690A1/en not_active Ceased
- 1997-08-07 DK DK97941921T patent/DK0932597T3/da active
- 1997-08-07 PT PT97941921T patent/PT932597E/pt unknown
- 1997-08-07 AT AT97941921T patent/ATE215065T1/de active
- 1997-08-07 US US09/242,048 patent/US6436998B1/en not_active Expired - Lifetime
- 1997-08-07 AU AU43790/97A patent/AU4379097A/en not_active Abandoned
- 1997-08-07 HU HU9902437A patent/HU228595B1/hu unknown
- 1997-08-07 EP EP97941921A patent/EP0932597B1/en not_active Expired - Lifetime
- 1997-08-07 JP JP50937298A patent/JP4259615B2/ja not_active Expired - Lifetime
-
2001
- 2001-12-11 US US10/013,971 patent/US6770784B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0932597A1 (en) | 1999-08-04 |
| JP4259615B2 (ja) | 2009-04-30 |
| ES2174287T3 (es) | 2002-11-01 |
| DK0932597T3 (da) | 2002-06-24 |
| WO1998006690A1 (en) | 1998-02-19 |
| US20020165224A1 (en) | 2002-11-07 |
| US6770784B2 (en) | 2004-08-03 |
| HUP9902437A3 (en) | 2001-07-30 |
| ITMI961732A1 (it) | 1998-02-09 |
| ITMI961732A0 (OSRAM) | 1996-08-09 |
| IT1283782B1 (it) | 1998-04-30 |
| ATE215065T1 (de) | 2002-04-15 |
| EP0932597B1 (en) | 2002-03-27 |
| US6436998B1 (en) | 2002-08-20 |
| CA2263328A1 (en) | 1998-02-19 |
| CA2263328C (en) | 2006-07-25 |
| DE69711411D1 (de) | 2002-05-02 |
| HU228595B1 (en) | 2013-04-29 |
| DE69711411T2 (de) | 2002-11-07 |
| JP2000516225A (ja) | 2000-12-05 |
| PT932597E (pt) | 2002-09-30 |
| HUP9902437A2 (hu) | 1999-12-28 |
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