AU4184597A - Histidine-tagged shiga toxins, toxoids, and protein fusions with such toxins and toxoids, methods for the purification and preparation thereof - Google Patents
Histidine-tagged shiga toxins, toxoids, and protein fusions with such toxins and toxoids, methods for the purification and preparation thereofInfo
- Publication number
- AU4184597A AU4184597A AU41845/97A AU4184597A AU4184597A AU 4184597 A AU4184597 A AU 4184597A AU 41845/97 A AU41845/97 A AU 41845/97A AU 4184597 A AU4184597 A AU 4184597A AU 4184597 A AU4184597 A AU 4184597A
- Authority
- AU
- Australia
- Prior art keywords
- shiga
- toxin
- toxins
- shiga toxin
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2563796P | 1996-09-10 | 1996-09-10 | |
| US60025637 | 1996-09-10 | ||
| PCT/US1997/015836 WO1998011229A2 (fr) | 1996-09-10 | 1997-09-09 | Toxines et toxoides shiga a marques par l'histidine, fusions de proteines avec ces toxines et toxoides, et leurs procedes de purification et de preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4184597A true AU4184597A (en) | 1998-04-02 |
Family
ID=21827219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU41845/97A Abandoned AU4184597A (en) | 1996-09-10 | 1997-09-09 | Histidine-tagged shiga toxins, toxoids, and protein fusions with such toxins and toxoids, methods for the purification and preparation thereof |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0929679A2 (fr) |
| JP (1) | JP2001500730A (fr) |
| AR (1) | AR010218A1 (fr) |
| AU (1) | AU4184597A (fr) |
| CA (1) | CA2265887A1 (fr) |
| WO (1) | WO1998011229A2 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2766193B1 (fr) | 1997-07-18 | 2001-09-14 | Inst Curie | Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique |
| GB9715177D0 (en) * | 1997-07-21 | 1997-09-24 | Neutec Pharma Plc | Medicament |
| ATE310750T1 (de) * | 1998-05-15 | 2005-12-15 | Inst Curie | Verotoxin b untereinheit zur immunisierunug |
| EP1057895A1 (fr) * | 1999-06-04 | 2000-12-06 | Lohmann Animal Health GmbH & Co. KG | Protéine de fusion comprenant le fragment B de la toxine de Shiga, préparation (vaccinale) la comprenant, et procédé pour leur préparation |
| WO2007098201A2 (fr) * | 2006-02-16 | 2007-08-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Protéines chimériques du toxoïde de shiga |
| JP2009536818A (ja) * | 2006-04-20 | 2009-10-22 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 志賀毒性１型タンパク質に基づく方法および組成物 |
| CN102292098A (zh) | 2009-01-23 | 2011-12-21 | 杰克孙M.亨利基金会先进军事医学有限公司 | 基于志贺毒素2型蛋白的方法和组合物 |
| LT2970487T (lt) * | 2013-03-12 | 2020-05-11 | Molecular Templates, Inc. | Citotoksiniai baltymai, apimantys tikslinių ląstelių rišimosi sritis ir shiga toksino subvienetų sritis, skirtas selektyviam tam tikrų rūšių ląstelių žudymui |
| ES2877356T3 (es) | 2014-01-27 | 2021-11-16 | Molecular Templates Inc | Epítopo de MHC de clase I que suministra polipéptidos |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| ES2723774T3 (es) * | 2014-03-11 | 2019-09-02 | Molecular Templates Inc | Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal |
| SI3604333T1 (sl) * | 2014-03-11 | 2021-08-31 | Molecular Templates, Inc. | Proteini, ki obsegajo aminoterminalne proksimalne Shiga toksin podenota A efektorske regije in celico-ciljajoče vezavne regije imunogobulinskega tipa, ki so sposobne specifične vezave CD38 |
| CN106604934A (zh) | 2014-06-11 | 2017-04-26 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
| AU2016215205B2 (en) | 2015-02-05 | 2021-10-21 | Molecular Templates, Inc. | Multivalent CD20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof |
| EP3660035A1 (fr) | 2015-05-30 | 2020-06-03 | Molecular Templates, Inc. | Supports de sous-unité a de toxine de shiga, déimmunisés, et molécules de ciblage de cellule les comprenant |
| KR102580647B1 (ko) | 2016-12-07 | 2023-09-20 | 몰레큘러 템플레이츠, 인코퍼레이션. | 부위 특이적 접합을 위한 시가 독소 a 서브유닛 작동체 폴리펩타이드, 시가 독소 작동체 스캐폴드, 및 세포-표적화 분자 |
| CN110536695B (zh) | 2017-01-25 | 2024-05-10 | 分子模板公司 | 包括去免疫化的志贺毒素a亚基效应子和cd8+ t细胞表位的细胞靶向分子 |
| JP7323200B2 (ja) | 2018-04-17 | 2023-08-08 | モレキュラー テンプレーツ，インク． | 脱免疫化志賀毒素ａサブユニット足場を含むｈｅｒ２ターゲティング分子 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT78048A (hu) * | 1994-10-24 | 1999-07-28 | Ophidian Pharmaceuticals, Inc. | A C. difficile által okozott betegség kezelésére és megelőzésére szolgáló vakcina és antitoxin |
| CA2218601A1 (fr) * | 1995-03-24 | 1996-10-03 | Ophidian Pharmaceuticals, Inc. | Traitement contre escherichia coli producteur de verotoxines |
-
1997
- 1997-09-09 JP JP10513748A patent/JP2001500730A/ja active Pending
- 1997-09-09 AR ARP970104115A patent/AR010218A1/es unknown
- 1997-09-09 CA CA002265887A patent/CA2265887A1/fr not_active Abandoned
- 1997-09-09 EP EP97939845A patent/EP0929679A2/fr not_active Withdrawn
- 1997-09-09 WO PCT/US1997/015836 patent/WO1998011229A2/fr not_active Application Discontinuation
- 1997-09-09 AU AU41845/97A patent/AU4184597A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0929679A2 (fr) | 1999-07-21 |
| CA2265887A1 (fr) | 1998-03-19 |
| WO1998011229A2 (fr) | 1998-03-19 |
| JP2001500730A (ja) | 2001-01-23 |
| WO1998011229A3 (fr) | 1998-04-16 |
| AR010218A1 (es) | 2000-06-07 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |